Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

Adachi-Yamada, 1999, Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing, Nature, 400, 166, 10.1038/22112

Adachi-Yamada, 1999, De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs, Mol. Cell. Biol., 19, 7276, 10.1128/MCB.19.10.7276

Aggarwal, 2003, Signalling pathways of the TNF superfamily: a double-edged sword, Nat. Rev. Immunol., 3, 745, 10.1038/nri1184

Agnes, 1999, The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis, Development, 126, 5453, 10.1242/dev.126.23.5453

Agrawal, 1995, Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila, Dev. Biol., 172, 218, 10.1006/dbio.1995.0017

Bilder, 2004, Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors, Genes Dev., 18, 1909, 10.1101/gad.1211604

Bilder, 2000, Localization of apical epithelial determinants by the basolateral PDZ protein Scribble, Nature, 403, 676, 10.1038/35001108

Bissell, 2001, Putting tumours in context, Nat. Rev. Cancer, 1, 46, 10.1038/35094059

Brumby, 2003, scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila, EMBO J., 22, 5769, 10.1093/emboj/cdg548

Bucci, 1992, The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway, Cell, 70, 715, 10.1016/0092-8674(92)90306-W

Entchev, 2000, Gradient formation of the TGF-beta homolog Dpp, Cell, 103, 981, 10.1016/S0092-8674(00)00200-2

Fish, 1994, Alterations in epithelial polarity and the pathogenesis of disease states, N. Engl. J. Med., 330, 1580, 10.1056/NEJM199406023302207

Floyd, 1998, Endocytosis proteins and cancer: a potential link?, Trends Cell Biol., 8, 299, 10.1016/S0962-8924(98)01316-6

Hariharan, 2006, Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila, Annu. Rev. Genet., 40, 335, 10.1146/annurev.genet.39.073003.100738

Igaki, 2002, Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway, EMBO J., 21, 3009, 10.1093/emboj/cdf306

Igaki, 2006, Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila, Curr. Biol., 16, 1139, 10.1016/j.cub.2006.04.042

Kanda, 2002, Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling, J. Biol. Chem., 277, 28372, 10.1074/jbc.C200324200

Kinzler, 1996, Lessons from hereditary colorectal cancer, Cell, 87, 159, 10.1016/S0092-8674(00)81333-1

Locksley, 2001, The TNF and TNF receptor superfamilies: integrating mammalian biology, Cell, 104, 487, 10.1016/S0092-8674(01)00237-9

Lowe, 2004, Intrinsic tumour suppression, Nature, 432, 307, 10.1038/nature03098

Lu, 2005, Endocytic control of epithelial polarity and proliferation in Drosophila, Nat. Cell Biol., 7, 1232, 10.1038/ncb1324

McDonald, 2000, Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3, Science, 290, 1574, 10.1126/science.290.5496.1574

Miaczynska, 2004, Not just a sink: endosomes in control of signal transduction, Curr. Opin. Cell Biol., 16, 400, 10.1016/j.ceb.2004.06.005

Moberg, 2005, Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth, Dev. Cell, 9, 699, 10.1016/j.devcel.2005.09.018

Moreno, 2002, Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily, Curr. Biol., 12, 1263, 10.1016/S0960-9822(02)00954-5

Pagliarini, 2003, A genetic screen in Drosophila for metastatic behavior, Science, 302, 1227, 10.1126/science.1088474

Stowers, 1999, A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype, Genetics, 152, 1631, 10.1093/genetics/152.4.1631

Tapon, 2002, salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines, Cell, 110, 467, 10.1016/S0092-8674(02)00824-3

Tepass, 2001, Epithelial cell polarity and cell junctions in Drosophila, Annu. Rev. Genet., 35, 747, 10.1146/annurev.genet.35.102401.091415

Thompson, 2005, Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila, Dev. Cell, 9, 711, 10.1016/j.devcel.2005.09.020

Uhlirova, 2005, Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model, Proc. Natl. Acad. Sci. USA, 102, 13123, 10.1073/pnas.0504170102

Vaccari, 2005, The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking, Dev. Cell, 9, 687, 10.1016/j.devcel.2005.09.019

Woods, 1991, The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions, Cell, 66, 451, 10.1016/0092-8674(81)90009-X

Wucherpfennig, 2003, Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release, J. Cell Biol., 161, 609, 10.1083/jcb.200211087