Impairment of protein ubiquitination may cause delayed neuronal death

Anathan, 1986, Abnormal proteins serve as cukaryotic stress signals and trigger the activation of the heat shock genes, Science, 232, 522, 10.1126/science.3083508 Atkinson, 1985 Bond, 1985, Ubiquitin is a heat shock protein in chicken embryo fibroblasts, Mol. Cell. Biol., 5, 949, 10.1128/MCB.5.5.949 Finley, 1984, Thermoliability of ubiquitin activating enzyme from the mammalian cell cycle mutant ts 85, Cell., 37, 43, 10.1016/0092-8674(84)90299-X Finley, 1985, The ubiquitin system: functions and mechanisms, TIBS, 9, 343 Haas, 1985, The immunochemical detection and quantitation of intracellular ubiquitinprotein conjugates, J. Biol. Chem., 260, 12464, 10.1016/S0021-9258(17)38895-6 Jörgensen, 1987, Removal of the entorhinal cortex protects hippocampal CA-1 neurons from ischemic damage, Acta Neuropathol., 73, 189, 10.1007/BF00693788 Kiessling, 1986, Protein synthesis in post ischemic rat brain a two-dimensional electrophoretic analysis, J. Cereb. Blood Flow Metab., 6, 642, 10.1038/jcbfm.1986.119 Kirino, 1982, Delayed neuronal death in the gerbil hippocampus following ischemia, Brain Res., 239, 57, 10.1016/0006-8993(82)90833-2 Meyer, 1987, Ubiquitin-directed antibodies inhibit neuronal transporters in rat brain synaptosomes, J. Neurochem., 49, 1815, 10.1111/j.1471-4159.1987.tb02441.x Monaghan, 1983, Anatomical distributions of four pharmacologically distinct 3H-glutamate binding sites, Nature (Lond.), 306, 176, 10.1038/306176a0 Mori, 1987, Ubiquitin is a component of paired helical filaments in Alzheimer's disease, Science, 235, 1641, 10.1126/science.3029875 Nowak, 1985, Synthesis of a stress protein following transient ischemia in the gerbil, J. Neurochem., 5, 1635, 10.1111/j.1471-4159.1985.tb07236.x Pulsinelli, 1982, Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann. Neurol., 11, 491, 10.1002/ana.410110509 Pulsinelli, 1983, Regional energy balance in rat brain after transient forebrain ischemia, J. Neurochem., 40, 1500, 10.1111/j.1471-4159.1983.tb13599.x Rechsteiner, 1987, Ubiquitin-mediated pathways for intracellular proteolysis, Annu. Rev. Cell Biol., 3, 1, 10.1146/annurev.cb.03.110187.000245 Sloviter, 1987, Immunocytochemical localization of GABA-, cholecystokinine-, vasoactive intestinal polypeptide-, and somatostatin-like immunoreactivity in the area dentata and hippocampus of the rat, J. Comp. Neurol., 256, 42, 10.1002/cne.902560105 Smith, 1984, Modes for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model, Acta Neurol. Scand., 69, 385, 10.1111/j.1600-0404.1984.tb07822.x Vass, K., Welch, W.J. and Nowak, T.S., Jr., Localization of 70 kDa stress protein induction in gerbil brain after ischemia, Acta Neuropathol., in press. Wieloch, 1985, Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path, Neurol. Res., 7, 24, 10.1080/01616412.1985.11739695