In situ-forming hydrogels—review of temperature-sensitive systems
Tài liệu tham khảo
R.L. Dunn, J.P. English, D.R. Cowsar, D.P. Vanderbilt, Biodegradable in-situ forming implants and methods of producing the same, US Patent 4,938,763, 1990.
Shively, 1995, Physico-chemical characterization of a polymeric injectable implant delivery system, J. Control. Release, 33, 237, 10.1016/0168-3659(94)00097-E
Eliaz, 2000, Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins, J. Biomed. Mater. Res., 50, 388, 10.1002/(SICI)1097-4636(20000605)50:3<388::AID-JBM13>3.0.CO;2-F
Haglund, 1996, An in situ gelling system for parenteral delivery, J. Control. Release, 41, 229, 10.1016/0168-3659(96)01333-8
Eliaz, 2002, Robust and prolonged gene expression from injectable polymeric implants, Gene Ther., 9, 1230, 10.1038/sj.gt.3301786
An, 2000, Intraarterial protein delivery via intimally-adherent bilayer hydrogels, J. Control. Release, 64, 205, 10.1016/S0168-3659(99)00143-1
Ono, 2000, Photocrosslinkable chitosan as a biological adhesive, J. Biomed. Mater. Res., 49, 289, 10.1002/(SICI)1097-4636(200002)49:2<289::AID-JBM18>3.0.CO;2-M
Ishihara, 2002, Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process, Biomaterials, 23, 833, 10.1016/S0142-9612(01)00189-2
Ishihara, 2002, Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization, J. Biomed. Mater. Res., 64A, 551
Obara, 2003, Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice, Biomaterials, 24, 3437, 10.1016/S0142-9612(03)00220-5
Burkoth, 2000, A review of photocrosslinked polyanhydrides: in situ forming degradable networks, Biomaterials, 21, 2395, 10.1016/S0142-9612(00)00107-1
Rozier, 1989, Gelrite: A novel, ion-activated, in-situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol, Int. J. Pharm., 57, 163, 10.1016/0378-5173(89)90305-0
Cohen, 1997, A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye, J. Control. Release, 44, 201, 10.1016/S0168-3659(96)01523-4
Kumar, 1994, In situ-forming gels for ophthalmic drug delivery, J. Ocul. Pharmacol., 10, 47, 10.1089/jop.1994.10.47
Srividya, 2001, Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system, J. Control. Release, 73, 205, 10.1016/S0168-3659(01)00279-6
Taylor, 1975, Preparation of films exhibiting a balanced temperature dependence to permeation by aqueous solutions—a study of lower consolute behavior, J. Polym. Sci. Polym. Chem. Ed., 13, 2551, 10.1002/pol.1975.170131113
Heskins, 1968, Solution properties of poly(N-isopropylacrylamide), J. Macromol. Sci. Chem., A2, 1441, 10.1080/10601326808051910
Schild, 1992, Poly(N-isopropylacrylamide): experiment, theory and application, Prog. Polym. Sci., 17, 163, 10.1016/0079-6700(92)90023-R
Hoffman, 1997, Intelligent polymers, 485
Mortensen, 1993, Structural study on the micelle formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer in aqueous solution, Macromolecules, 26, 805, 10.1021/ma00056a035
Harrington, 1961, The structure of collagen and gelatin, Adv. Protein Chem., 16, 1, 10.1016/S0065-3233(08)60028-5
Anderson, 1969, X-ray diffraction studies of polysaccharide sulphates: double helix models for κ- and ι-carrageenans, J. Mol. Biol., 45, 85, 10.1016/0022-2836(69)90211-3
Heymann, 1935, Studies on sol–gel transformations, I. The inverse sol–gel transformation of methylcellulose in water, Trans. Faraday Soc., 31, 846, 10.1039/tf9353100846
Sarkar, 1979, Thermal gelation properties of methyl and hydroxypropyl methylcellulose, J. Appl. Polym. Sci., 24, 1073, 10.1002/app.1979.070240420
Tate, 2001, Biocompatibility of methylcellulose-based constructs designed for intracerebral gelation following experimental traumatic brain injury, Biomaterials, 22, 1113, 10.1016/S0142-9612(00)00348-3
Carlsson, 1988, Interaction between ethyl(hydroxyethyl)cellulose and sodium dodecyl sulphate in aqueous solution, Colloid Polym. Sci., 266, 1031, 10.1007/BF01428813
Carlsson, 1990, Thermal gelation of nonionic cellulose ethers and ionic surfactants in water, Colloids Surf., 47, 147, 10.1016/0166-6622(90)80069-G
Nystrom, 1995, Rheological behavior during thermoreversible gelation of aqueous mixtures of ethyl(hydroxyethyl)cellulose and surfactants, Langmuir, 11, 750, 10.1021/la00003a014
Carlsson, 1989, Polymer-surfactant interactions. Binding of N-tetradecylpyridinium bromide to ethyl(hydroxyethyl)cellulose), Langmuir, 5, 1250, 10.1021/la00089a022
Lindman, 1990, Nonionic polymers and surfactants—some anomalies in temperature dependence and in interactions with ionic surfactants, Adv. Colloid Interface Sci., 32, 183, 10.1016/0001-8686(90)80018-U
Scherlund, 2000, Nonionic cellulose ethers as potential drug delivery systems for periodontal anesthesia, J. Colloid Interface Sci., 229, 365, 10.1006/jcis.2000.7006
Shirakawa, 1998, Tailoring xyloglucan properties using an enzyme, Food Hydrocolloids, 12, 25, 10.1016/S0268-005X(98)00052-6
Miyazaki, 1998, Thermally reversible xyloglucan gels as vehicles for rectal drug delivery, J. Control. Release, 56, 75, 10.1016/S0168-3659(98)00079-0
Suisha, 1998, Xyloglucan gels as sustained release vehicles for the intraperitoneal administration of mitomycin C, Int. J. Pharm., 172, 27, 10.1016/S0378-5173(98)00157-4
Kawasaki, 1999, Thermally reversible xyloglucan gels as vehicles for oral drug delivery, Int. J. Pharm., 181, 227, 10.1016/S0378-5173(99)00026-5
Miyazaki, 2001, Oral sustained delivery of theophylline from thermally reversible xyloglucan gels in rabbits, J. Pharm. Pharmacol., 53, 1185, 10.1211/0022357011776621
Miyazaki, 2001, In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride, Int. J. Pharm., 229, 29, 10.1016/S0378-5173(01)00825-0
Takahashi, 2002, Percutaneous absorption of non-steroidal anti-inflammatory drugs from in situ gelling xyloglucan formulations in rats, Int. J. Pharm., 246, 179, 10.1016/S0378-5173(02)00394-0
Chenite, 2000, Novel injectable neutral solutions of chitosan form biodegradable gels in situ, Biomaterials, 21, 2155, 10.1016/S0142-9612(00)00116-2
Chenite, 2001, Rheological characterization of thermogelling chitosan/glycerol-phosphate solutions, Carbohydr. Polym., 46, 39, 10.1016/S0144-8617(00)00281-2
Ruel-Gariépy, 2000, Characterization of thermosensitive chitosan gels for the sustained delivery of drugs, Int. J. Pharm., 203, 89, 10.1016/S0378-5173(00)00428-2
Ruel-Gariépy, 2002, Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules, J. Control. Release, 82, 373, 10.1016/S0168-3659(02)00146-3
Ruel-Gariépy, 2004, A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel, Eur. J. Pharm. Biopharm., 57, 53, 10.1016/S0939-6411(03)00095-X
Hoemann, 2001, A thermosensitive polysaccharide gel for cell delivery in cartilage repair, Trans. Orthop. Res. Soc., 26, 626
Hoemann, 2003
Molinaro, 2002, Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials, Biomaterials, 23, 2717, 10.1016/S0142-9612(02)00004-2
Jarry, 2001, Effects of steam sterilization on thermogelling chitosan-based gels, J. Biomed. Mater. Res. (Appl. Biomater.), 58, 127, 10.1002/1097-4636(2001)58:1<127::AID-JBM190>3.0.CO;2-G
Jarry, 2002, Irradiating or autoclaving chitosan/polyol solutions: Effect on thermogelling chitosan-β-glycerophosphate systems, Chem. Pharm. Bull., 50, 1335, 10.1248/cpb.50.1335
Hoffman, 1986, Thermally reversible hydrogels: II. Delivery and selective removal of substances from aqueous solutions, J. Control. Release, 4, 213, 10.1016/0168-3659(86)90005-2
Hirotsu, 1987, Volume-phase transitions of ionized N-isopropylacrylamide gels, J. Chem. Phys., 87, 1392, 10.1063/1.453267
Feil, 1993, Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers, Macromolecules, 26, 2496, 10.1021/ma00062a016
Han, 1998, Inverse thermally-reversible gelation of aqueous N-isopropylacrylamide copolymer solutions, Polymer, 39, 2809, 10.1016/S0032-3861(97)00612-5
Vernon, 1996, Thermally reversible polymer gels for biohybrid artificial pancreas, Macromol. Symp., 109, 155, 10.1002/masy.19961090115
Bae, 1998, Extracellular matrix for a rechargeable cell delivery system, J. Control. Release, 53, 249, 10.1016/S0168-3659(97)00258-7
Vernon, 1999, Insulin release from islets of Langerhans entrapped in a poly(N-isopropylacrylamide-co-acrylic acid) polymer gel, J. Biomater. Sci. Polym. Ed., 10, 183, 10.1163/156856299X00126
Gappa, 2001, The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets, Tissue Eng., 7, 35, 10.1089/107632701300003278
Chae, 2002, Effects of cross-linked hemoglobin on functionality and viability of microencapsulated pancreatic islets, Tissue Eng., 8, 379, 10.1089/107632702760184655
Chae, 2001, Bioactive polymers for biohybrid artificial pancreas, J. Drug Target., 9, 473, 10.3109/10611860108998781
Park, 2002, Phenotype of hepatocyte spheroids in Arg-Gly-Asp (RGD) containing a thermo-reversible extracellular matrix, Biosci. Biotechnol. Biochem., 66, 1473, 10.1271/bbb.66.1473
Lin, 2001, In-situ thermoreversible gelation of block and star copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) of varying architectures, Macromolecules, 34, 3710, 10.1021/ma001852m
Rassing, 1983, Ultrasonic velocity and light-scattering studies on the polyoxyethylene-polyoxypropylene copolymer Pluronic F127 in aqueous solution, Int. J. Pharm., 13, 47, 10.1016/0378-5173(82)90141-7
Zhou, 1987, Anomalous association behavior of an ethylene oxide/propylene oxide ABA block copolymer in water, Macromolecules, 20, 3089, 10.1021/ma00178a027
Zhou, 1988, Light-scattering study on the association behavior of triblock polymers of ethylene oxide and propylene oxide in aqueous solution, J. Colloid Interface Sci., 126, 171, 10.1016/0021-9797(88)90111-7
Wanka, 1990, The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution, Colloid Polym. Sci., 268, 101, 10.1007/BF01513189
Mortensen, 1993, Block copolymer in aqueous solution: Micelle formation and hard-sphere crystallization, Progr. Colloid Polym. Sci., 93, 72, 10.1007/BFb0118477
Schillén, 1993, Characterization of a PEO-PPO-PEO block copolymer system, Progr. Colloid Polym. Sci., 93, 66, 10.1007/BFb0118476
Bohorquez, 1999, A study of the temperature-dependent micellization of pluronic F127, J. Colloid Interface Sci., 216, 34, 10.1006/jcis.1999.6273
Cabana, 1997, Study of the gelation process of polyethylene oxide-polypropylene oxide-polyethylene oxide copolymer (poloxamer 407) aqueous solutions, J. Colloid Interface Sci., 190, 307, 10.1006/jcis.1997.4880
Schmolka, 1972, Artificial skin 1. Preparation and properties of Pluronic F-127 gels for treatment of burns, J. Biomed. Mater. Res., 6, 571, 10.1002/jbm.820060609
Miyazaki, 1984, Pluronic F-127 gels as a vehicle for topical administration of anticancer agents, Chem. Pharm. Bull., 32, 4205, 10.1248/cpb.32.4205
Johnston, 1989, Inulin disposition following intramuscular administration of an inulin/poloxamer gel matrix, J. Parent. Sci. Technol., 43, 279
Katakam, 1997, Controlled release of human growth hormone in rats following parenteral administration of poloxamer gels, J. Control. Release, 49, 21, 10.1016/S0168-3659(97)01648-9
Veyries, 1999, Controlled release of vancomycin from poloxamer gels, Int. J. Pharm., 192, 183, 10.1016/S0378-5173(99)00307-5
Paavola, 2000, Controlled release injectable liposomal gel of ibuprofen for epidural analgesia, Int. J. Pharm., 199, 85, 10.1016/S0378-5173(00)00376-8
Wenzel, 2002, Pluronic F127 gel formulations of Deslorelin and GnRH reduce drug degradation and sustain drug release and effect in cattle, J. Control. Release, 85, 51, 10.1016/S0168-3659(02)00271-7
Zhang, 2002, Development and in-vitro evaluation of sustained release poloxamer 407 (P407) gel formulations of ceftiofur, J. Control. Release, 85, 73, 10.1016/S0168-3659(02)00273-0
Choi, 1998, Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository, Int. J. Pharm., 165, 33, 10.1016/S0378-5173(97)00386-4
Ryu, 1999, Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum, J. Control. Release, 59, 163, 10.1016/S0168-3659(98)00189-8
Chang, 2002, Rheological evaluation of thermosensitive and mucoadhesive vaginals gels in physiological conditions, Int. J. Pharm., 241, 155, 10.1016/S0378-5173(02)00232-6
Chang, 2002, Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis, J. Control. Release, 82, 39, 10.1016/S0168-3659(02)00086-X
Shin, 2000, Enhanced efficacy by percutaneous absorption of piroxicam from the poloxamer gel in rats, Int. J. Pharm., 193, 213, 10.1016/S0378-5173(99)00339-7
Liaw, 2000, Evaluation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) gels as a release vehicle for percutaneous fentanyl, J. Control. Release, 68, 273, 10.1016/S0168-3659(00)00268-6
El-Kamel, 2002, In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate, Int. J. Pharm., 241, 47, 10.1016/S0378-5173(02)00234-X
Wei, 2002, Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies, J. Control. Release, 83, 65, 10.1016/S0168-3659(02)00175-X
Johnston, 1985, Toxicological evaluation of poloxamer vehicles for intramuscular use, J. Parent. Sci. Technol., 39, 83
Wout, 1992, Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats, J. Parent. Sci. Technol., 46, 192
Palmer, 1998, Poloxamer 407-induced atherogenesis in the C57BL/6 mouse, Atherosclerosis, 136, 115, 10.1016/S0021-9150(97)00193-7
Johnston, 1993, Mechanism of poloxamer 407-induced hypertriglyceridemia in the rat, Biochem. Pharmacol., 46, 1037, 10.1016/0006-2952(93)90668-M
Blonder, 1999, Dose-dependent hyperlipidemia in rabbits following administration of poloxamer 407 gel, Life Sci., 65, 261, 10.1016/S0024-3205(99)00495-6
Zhao, 2003, Oligomers of poloxamer 407 as degradable thermal sensitive depot materials for sustained drug release, Proc. Int. Symp. Control. Rel. Bioact. Mater., 30, 167
Cohn, 2003, Improved reverse thermo-responsive polymeric systems, Biomaterials, 24, 3707, 10.1016/S0142-9612(03)00245-X
Chen, 1995, Graft copolymers that exhibit temperature-induced phase transition over a wide range of pH, Nature, 373, 49, 10.1038/373049a0
Hoffman, 1995, New bioadhesive polymer compositions for prolonged drug release in the eye, Proc. Int. Symp. Control. Rel. Bioact. Mater., 22, 159
Hoffman, 1997, Graft copolymers of PEO-PPO-PEO triblock polyethers on bioadhesive polymer backbones: Synthesis and properties, Polym. Prepr., 38, 524
A.S. Hoffman, G. Chen, Block and graft copolymers and methods relating thereto, Int. Pat. Appl. W/O 95/24430, 1995.
L. Bromberg, E.C. Lupton, M.E. Schiller, M.J. Timm, G.W. McKinney, M. Orkisz, B. Hand, Responsive polymer networks and methods of their use, Int. Pat. Appl. WO 97/00275, 1997.
Bromberg, 1998, Novel family of thermogelling materials via C–C bonding between poly(acrylic acid) and poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), J. Phys. Chem. B, 102, 1956, 10.1021/jp9803687
Bromberg, 1998, Polyether-modified poly(acrylic acid): synthesis and applications, Ind. Eng. Chem. Res., 37, 4267, 10.1021/ie980358s
Bromberg, 1998, Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery, Adv. Drug Del. Rev., 31, 197, 10.1016/S0169-409X(97)00121-X
Bromberg, 1998, Scaling of rheological properties of hydrogels from associating polymers, Macromolecules, 31, 6148, 10.1021/ma980523f
Bromberg, 1998, Self-assembly in aqueous solutions of polyether-modified poly(acrylic acid), Langmuir, 14, 5806, 10.1021/la980737q
Bromberg, 1998, Properties of aqueous solutions and gels of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-g-poly(acrylic acid), J. Phys. Chem. B, 102, 10736, 10.1021/jp983162e
Bromberg, 1997, Bioadhesive properties of polyethylene-b-polyoxypropylene-b-polyoxyethylene-g-poly(acrylic acid) polymers (Smart Hydrogel™), Polym. Prepr., 38, 626
Ron, 1997, Smart hydrogel: a novel mucosal delivery system, Proc. Int. Symp. Control. Rel. Bioact. Mater., 24, 407
Ron, 1996, Interpenetrating polymer networks for sustained dermal delivery, Proc. Int. Symp. Control. Rel. Bioact. Mater., 23, 128
Potts, 1997, In vivo determination of the oesophageal retention of smart hydrogel, Proc. Int. Symp. Control. Rel. Bioact. Mater., 24, 335
Bromberg, 1997, Polyoxyethylene-b-polyoxypropylene-b-polyoxyethylene-g-poly(acrylic acid) polymers (Smart Hydrogel™) as a carrier in controlled delivery of proteins and peptides, Polym. Prepr., 38, 602
Jeong, 1997, Biodegradable block copolymers as injectable drug-delivery systems, Nature, 388, 860, 10.1038/42218
Jeong, 1999, Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers, Colloids Surf. B, 16, 185, 10.1016/S0927-7765(99)00069-7
Jeong, 1999, Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions, Macromolecules, 32, 7064, 10.1021/ma9908999
Kwon, 2002, Gelation behavior of PEO-PLGA-PEO triblock copolymers in water, Polymer, 43, 3353, 10.1016/S0032-3861(02)00155-6
Jeong, 2000, Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers, J. Control. Release, 63, 155, 10.1016/S0168-3659(99)00194-7
Jeong, 2000, In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof, J. Biomed. Mater. Res., 50, 171, 10.1002/(SICI)1097-4636(200005)50:2<171::AID-JBM11>3.0.CO;2-F
Jeong, 2000, Thermogelling biodegradable polymers with hydrophilic backbones: PEG-g-PLGA, Macromolecules, 33, 8317, 10.1021/ma000638v
Jeong, 2001, Biodegradable thermoreversible gelling PLGA-g-PEG copolymers, Chem. Commun., 1516, 10.1039/b102819g
Chung, 2002, Sol–gel transition temperature of PLGA-g-PEG aqueous solutions, Biomacromolecules, 3, 511, 10.1021/bm0156431
Jeong, 2002, Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering, Biomacromolecules, 3, 865, 10.1021/bm025536m
R.C. Rathi, G.M. Zentner, Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties, U.S. Patent 6,004,573, 1999.
Zentner, 2001, Biodegradable block colpolymers for drug delivery of proteins and water-insoluble drugs, J. Control. Release, 72, 203, 10.1016/S0168-3659(01)00276-0
Fowers, 2003, Thermally reversible gelling materials for safe and versatile depot delivery, Drug Del. Technol., 3, 58
Kim, 2001, Controlled release of insulin from injectable biodegradable triblock copolymer, Pharm. Res., 18, 548, 10.1023/A:1011074915438
Messersmith, 1998, Thermally triggered calcium phosphate formation from calcium-loaded liposomes, Chem. Mater., 10, 117, 10.1021/cm9702528
Westhaus, 2001, Triggered release of calcium from lipid vesicles: a bioinspired strategy for rapid gelation of polysaccharide and protein hydrogel, Biomaterials, 22, 453, 10.1016/S0142-9612(00)00200-3
Westhaus, 1999
Sanborn, 2002, In situ crosslinking of a biomimetic peptide-PEG hydrogel via thermally triggered activation of factor XIII, Biomaterials, 23, 2703, 10.1016/S0142-9612(02)00002-9
Collier, 2001, Thermally and photochemically triggered self-assembly of peptide hydrogels, J. Am. Chem. Soc., 123, 9463, 10.1021/ja011535a
Song, 1999, A new class of biodegradable thermosensitive polymers. I. Synthesis and characterization of poly(organophosphazenes) with methoxy-poly(ethylene glycol) and amino acid esters as side groups, Macromolecules, 32, 2188, 10.1021/ma981190p
Lee, 1999, A new class of biodegradable thermosensitive polymers. 2. Hydrolytic properties and salt effect on the lower critical solution temperature of poly(organophosphazenes) with methoxypoly(ethylene glycol) and amino acid esters as side groups, Macromolecules, 32, 7820, 10.1021/ma990645n
Lee, 2000, Thermosensitive cyclotriphosphazenes, J. Am. Chem. Soc., 122, 8315, 10.1021/ja001542j
Lee, 2002, A thermosensitive poly(organophosphazene) gel, Macromolecules, 35, 3876, 10.1021/ma012093q
Wang, 2003, Injectable polyphosphate hydrogel, Proc. Int. Symp. Control. Rel. Bioact. Mater., 30, 140
Barichello, 1999, Absorption of insulin from pluronic F-127 gels following subcutaneous administration in rats, Int. J. Pharm., 184, 189, 10.1016/S0378-5173(99)00119-2
Amiji, 2002, Intratumoral administration of paclitaxel in an in situ gelling poloxamer 407 formulation, Pharm. Dev. Tech., 7, 195, 10.1081/PDT-120003487
