A Role for Topographic Cues in the Organization of Collagenous Matrix by Corneal Fibroblasts and Stem Cells

TJ Freegard, 1997, The physical basis of transparency of the normal cornea, Eye (Lond), 11, 465, 10.1038/eye.1997.127

RM Garana, 1992, Radial keratotomy. II. Role of the myofibroblast in corneal wound contraction, Invest Ophthalmol Vis Sci, 33, 3271

T Moller-Pedersen, 1998, Confocal microscopic characterization of wound repair after photorefractive keratectomy, Invest Ophthalmol Vis Sci, 39, 487

MP Beales, 1999, Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: maintenance of the keratocyte phenotype in culture, Invest Ophthalmol Vis Sci, 40, 1658

JL Funderburgh, 2001, Proteoglycan expression during transforming growth factor beta -induced keratocyte-myofibroblast transdifferentiation, J Biol Chem, 276, 44173, 10.1074/jbc.M107596200

JL Funderburgh, 1996, Synthesis of corneal keratan sulfate proteoglycans by bovine keratocytes in vitro, J Biol Chem, 271, 31431, 10.1074/jbc.271.49.31431

JL Funderburgh, 2003, Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis, J Biol Chem, 278, 45629, 10.1074/jbc.M303292200

CJ Long, 2000, Fibroblast growth factor-2 promotes keratan sulfate proteoglycan expression by keratocytes in vitro, J Biol Chem, 275, 13918, 10.1074/jbc.275.18.13918

BL Berryhill, 2002, Partial restoration of the keratocyte phenotype to bovine keratocytes made fibroblastic by serum, Invest Ophthalmol Vis Sci, 43, 3416

JR Hassell, 2010, The molecular basis of corneal transparency, Exp Eye Res, 91, 326, 10.1016/j.exer.2010.06.021

K Musselmann, 2005, Maintenance of the keratocyte phenotype during cell proliferation stimulated by insulin, J Biol Chem, 280, 32634, 10.1074/jbc.M504724200

X Guo, 2007, Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts, Invest Ophthalmol Vis Sci, 48, 4050, 10.1167/iovs.06-1216

D Karamichos, 2010, Human corneal fibrosis: an in vitro model, Invest Ophthalmol Vis Sci, 51, 1382, 10.1167/iovs.09-3860

R Ren, 2008, Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures, Dev Dyn, 237, 2705, 10.1002/dvdy.21606

D Karamichos, 2011, Transforming growth factor-beta3 regulates assembly of a non-fibrotic matrix in a 3D corneal model, J Tissue Eng Regen Med, 5, e228, 10.1002/term.429

Y Du, 2005, Multipotent stem cells in human corneal stroma, Stem Cells, 23, 1266, 10.1634/stemcells.2004-0256

Y Du, 2007, Secretion and organization of a cornea-like tissue in vitro by stem cells from human corneal stroma, Invest Ophthalmol Vis Sci, 48, 5038, 10.1167/iovs.07-0587

J Wu, 2012, The engineering of organized human corneal tissue through the spatial guidance of corneal stromal stem cells, Biomaterials, 33, 1343, 10.1016/j.biomaterials.2011.10.055

J Wu, 2013, Bioengineering Organized, Multi-Lamellar Human Corneal Stromal Tissue by Growth Factor Supplementation on Highly Aligned Synthetic Substrates, Tissue Eng Part A

BL Berryhill, 2001, Production of prostaglandin D synthase as a keratan sulfate proteoglycan by cultured bovine keratocytes, Invest Ophthalmol Vis Sci, 42, 1201

E Di Iorio, 2010, Localization and expression of CHST6 and keratan sulfate proteoglycans in the human cornea, Exp Eye Res, 91, 293, 10.1016/j.exer.2010.06.001

K Kitayama, 2007, Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans, J Biol Chem, 282, 30085, 10.1074/jbc.M703695200

Y Pei, 2006, Aldehyde dehydrogenase (ALDH) 3A1 expression by the human keratocyte and its repair phenotypes, Exp Eye Res, 83, 1063, 10.1016/j.exer.2006.05.011

J Ruiz-Ederra, 2009, Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models, Exp Eye Res, 89, 159, 10.1016/j.exer.2009.03.002

Y Du, 2009, Stem cell therapy restores transparency to defective murine corneas, Stem Cells, 27, 1635, 10.1002/stem.91

Y Du, 2010, Adipose-derived stem cells differentiate to keratocytes in vitro, Mol Vis, 16, 2680

N Pinnamaneni, 2012, Concise review: Stem cells in the corneal stroma, Stem Cells, 30, 1059, 10.1002/stem.1100

AA Chan, 2013, Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype, PLoS One, 8, e56831, 10.1371/journal.pone.0056831

F Ruggiero, 1996, Human corneal fibrillogenesis. Collagen V structural analysis and fibrillar assembly by stromal fibroblasts in culture, Invest Ophthalmol Vis Sci, 37, 1749

S Ohno, 2011, Prevention of buccal mucosa scarring with transforming growth factor beta3, Laryngoscope, 121, 1404, 10.1002/lary.21759

CR McLaughlin, 2009, Bioengineered corneas for transplantation and in vitro toxicology, Front Biosci, 14, 3326, 10.2741/3455

P Fagerholm, 2010, A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study, Sci Transl Med, 2, 46ra61, 10.1126/scitranslmed.3001022

EK Yim, 2010, Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells, Biomaterials, 31, 1299, 10.1016/j.biomaterials.2009.10.037

PY Wang, 2012, Modulation of osteogenic, adipogenic and myogenic differentiation of mesenchymal stem cells by submicron grooved topography, J Mater Sci Mater Med, 23, 3015, 10.1007/s10856-012-4748-6

OF Zouani, 2012, Altered nanofeature size dictates stem cell differentiation, J Cell Sci, 125, 1217, 10.1242/jcs.093229

LY Chan, 2013, Temporal application of topography to increase the rate of neural differentiation from human pluripotent stem cells, Biomaterials, 34, 382, 10.1016/j.biomaterials.2012.09.033

YJ Ren, 2013, Enhanced differentiation of human neural crest stem cells towards the Schwann cell lineage by aligned electrospun fiber matrix, Acta Biomater, 9, 7727, 10.1016/j.actbio.2013.04.034

J Seras-Franzoso, 2013, Topographically targeted osteogenesis of mesenchymal stem cells stimulated by inclusion bodies attached to polycaprolactone surfaces, Nanomedicine (Lond)

KE Myrna, 2012, Substratum topography modulates corneal fibroblast to myofibroblast transformation, Invest Ophthalmol Vis Sci, 53, 811, 10.1167/iovs.11-7982

MD Guillemette, 2009, Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function, Integr Biol (Camb), 1, 196, 10.1039/b820208g

SA Pot, 2010, Nanoscale topography-induced modulation of fundamental cell behaviors of rabbit corneal keratocytes, fibroblasts, and myofibroblasts, Invest Ophthalmol Vis Sci, 51, 1373, 10.1167/iovs.09-4074

SA Fraser, 2008, Sub-micron and nanoscale feature depth modulates alignment of stromal fibroblasts and corneal epithelial cells in serum-rich and serum-free media, J Biomed Mater Res A, 86, 725, 10.1002/jbm.a.31519

MI Huh, 2009, Distribution of TGF-beta isoforms and signaling intermediates in corneal fibrotic wound repair, J Cell Biochem, 108, 476, 10.1002/jcb.22277

LM Carrington, 2006, Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors, Invest Ophthalmol Vis Sci, 47, 1886, 10.1167/iovs.05-0635

M Shah, 1995, Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring, J Cell Sci, 108, 985, 10.1242/jcs.108.3.985

JC Jennings, 1988, Comparison of the biological actions of TGF beta-1 and TGF beta-2: differential activity in endothelial cells, J Cell Physiol, 137, 167, 10.1002/jcp.1041370120

T Barsby, 2013, Transforming growth factor beta3 promotes tendon differentiation of equine embryo-derived stem cells, Tissue Eng Part A, 19, 2156, 10.1089/ten.tea.2012.0372

M Kim, 2012, Transient exposure to TGF-beta3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels, J Mech Behav Biomed Mater, 11, 92, 10.1016/j.jmbbm.2012.03.006

D Karamichos, 2013, TGF-beta3 Stimulates Stromal Matrix Assembly by Human Corneal Keratocyte-Like Cells, Invest Ophthalmol Vis Sci, 54, 6612, 10.1167/iovs.13-12861

MK Wang, 2012, Different roles of TGF-beta in the multi-lineage differentiation of stem cells, World J Stem Cells, 4, 28, 10.4252/wjsc.v4.i5.28

JL Funderburgh, 2000, Keratan sulfate: structure, biosynthesis, and function, Glycobiology, 10, 951, 10.1093/glycob/10.10.951

K Musselmann, 2006, Focus on molecules: CHST6 (carbohydrate sulfotransferase 6; corneal N-acetylglucosamine-6-sulfotransferase), Exp Eye Res, 83, 707, 10.1016/j.exer.2005.11.020

RD Young, 2007, Differential immunogold localisation of sulphated and unsulphated keratan sulphate proteoglycans in normal and macular dystrophy cornea using sulphation motif-specific antibodies, Histochem Cell Biol, 127, 115, 10.1007/s00418-006-0228-8

WW Kao, 2002, Roles of lumican and keratocan on corneal transparency, Glycoconj J, 19, 275, 10.1023/A:1025396316169

ST Lee, 2013, Transformation of somatic cells into stem cell-like cells under a stromal niche, FASEB J, 27, 2644, 10.1096/fj.12-223065