Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Smythe, G. M. & Rando, T. A. Notch-mediated restoration of regenerative potential to aged muscle. Science 302, 1575–1577 (2003)

Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A. & Weissman, I. L. The aging of hematopoietic stem cells. Nature Med. 2, 1011–1016 (1996)

Fuller, J. Hematopoietic stem cells and aging. Sci. Aging Knowledge Environ., e11 (2002)

Sigal, S. H., Brill, S., Fiorino, A. S. & Reid, L. M. The liver as a stem cell and lineage system. Am. J. Physiol. 263, G139–G148 (1992)

Kuhn, H. G., Dickinson-Anson, H. & Gage, F. H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027–2033 (1996)

Conboy, I. M. & Rando, T. A. The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Dev. Cell 3, 397–409 (2002)

Iakova, P., Awad, S. S. & Timchenko, N. A. Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest. Cell 113, 495–506 (2003)

Golden, T. R., Hinerfeld, D. A. & Melov, S. Oxidative stress and aging: beyond correlation. Aging Cell 1, 117–123 (2002)

Hekimi, S. & Guarente, L. Genetics and the specificity of the aging process. Science 299, 1351–1354 (2003)

Tatar, M., Bartke, A. & Antebi, A. The endocrine regulation of aging by insulin-like signals. Science 299, 1346–1351 (2003)

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H. & Vijg, J. Aging and genome maintenance: lessons from the mouse? Science 299, 1355–1359 (2003)

Carlson, B. M. & Faulkner, J. A. Muscle transplantation between young and old rats: age of host determines recovery. Am. J. Physiol. 256, C1262–C1266 (1989)

Carlson, B. M., Dedkov, E. I., Borisov, A. B. & Faulkner, J. A. Skeletal muscle regeneration in very old rats. J. Gerontol. A 56, B224–B233 (2001)

McCay, C. M., Pope, F., Lunsford, W., Sperling, G. & Sambhavaphol, P. Parabiosis between old and young rats. Gerontologia 1, 7–17 (1957)

Finerty, J. Parabiosis in physiological studies. Physiol. Rev. 32, 277–302 (1952)

Tauchi, H. & Hasegawa, K. Change of the hepatic cells in parabiosis between old and young rats. Mech. Ageing Dev. 6, 333–339 (1977)

Sidorenko, A. V., Gubrii, I. B., Andrianova, L. F., Macsijuk, T. V. & Butenko, G. M. Functional rearrangement of lymphohemopoietic system in heterochronically parabiosed mice. Mech. Ageing Dev. 36, 41–56 (1986)

Wagers, A. J., Sherwood, R. I., Christensen, J. L. & Weissman, I. L. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297, 2256–2259 (2002)

Sherwood, R. I. et al. Isolation of adult mouse myogenic progenitors: Functional heterogeneity of cells within and engrafting skeletal muscle. Cell 119, 543–554 (2004)

Partridge, T. A. Cells that participate in regeneration of skeletal muscle. Gene Ther. 9, 752–753 (2002)

Sherwood, R. I., Christensen, J. L., Weissman, I. L. & Wagers, A. J. Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells. Stem Cells 22, 1292–1304 (2004)

Rosenblatt, J. D., Lunt, A. I., Parry, D. J. & Partridge, T. A. Culturing satellite cells from living single muscle fiber explants. In Vitro Cell. Dev. Biol. Anim. 31, 773–779 (1995)

Sell, S. Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 33, 738–750 (2001)

Timchenko, N. A. et al. Regenerating livers of old rats contain high levels of C/EBPα that correlate with altered expression of cell cycle associated proteins. Nucleic Acids Res. 26, 3293–3299 (1998)

Wright, D. E. et al. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood 97, 2278–2285 (2001)

Beauchamp, J. R. et al. Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells. J. Cell Biol. 151, 1221–1234 (2000)