Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials

ESMO Open - Tập 7 - Trang 100455 - 2022
D. König1, S. Schär2, D. Vuong3, M. Guckenberger3, K. Furrer4, I. Opitz4, W. Weder5, S.I. Rothschild1, A. Ochsenbein6, A. Zippelius1, A. Addeo7, M. Mark8, E.I. Eboulet2, S. Hayoz2, S. Thierstein2, D.C. Betticher9, H.-B. Ris10, R. Stupp11, A. Curioni-Fontecedro12, S. Peters13
1Department of Medical Oncology, University Hospital of Basel, Basel, Switzerland
2Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland
3Department of Radiation Oncology, University Hospital of Zurich, Zurich, Switzerland
4Department of Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland
5Clinics for Thoracic Surgery, Bethanien, Zurich, Switzerland
6Department of Medical Oncology, University Hospital of Bern (Inselspital), Bern, Switzerland
7Department of Oncology, University Hospital of Geneva, Geneva, Switzerland
8Department of Oncology, Cantonal Hospital of Graubünden, Chur, Switzerland
9Clinics of Medical Oncology, Cantonal Hospital of Fribourg (HFR), Fribourg, Switzerland
10Clinics for Thoracic Surgery, Hôpital du Valais, Sion, Switzerland
11Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, USA
12Department of Medical Oncology, University Hospital of Zurich, Zurich, Switzerland
13Department of Medical Oncology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland

Tài liệu tham khảo

Brierley, 2017 Antonia, 2017, Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer, N Engl J Med, 377, 1919, 10.1056/NEJMoa1709937 Faivre-Finn, 2021, Four-year survival with durvalumab after chemoradiotherapy in stage III NSCLC-an update from the PACIFIC trial, J Thorac Oncol, 16, 860, 10.1016/j.jtho.2020.12.015 Betticher, 2003, Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer: a multicenter phase II trial, J Clin Oncol, 21, 1752, 10.1200/JCO.2003.11.040 Stupp, 2009, Neoadjuvant chemotherapy and radiotherapy followed by surgery in selected patients with stage IIIB non-small-cell lung cancer: a multicentre phase II trial, Lancet Oncol, 10, 785, 10.1016/S1470-2045(09)70172-X Pless, 2015, Induction chemoradiation in stage IIIA/N2 non-small-cell lung cancer: a phase 3 randomised trial, Lancet, 386, 1049, 10.1016/S0140-6736(15)60294-X Curioni-Fontecedro, 2019, Preoperative chemotherapy and radiotherapy concomitant to cetuximab in resectable stage IIIB NSCLC: a multicentre phase 2 trial (SAKK 16/08), Br J Cancer, 120, 968, 10.1038/s41416-019-0447-0 Rothschild, 2021, SAKK 16/14: durvalumab in addition to neoadjuvant chemotherapy in patients with stage IIIA(N2) non-small-cell lung cancer-a multicenter single-arm phase II trial, J Clin Oncol, JCO2100276 Forde, 2018, Neoadjuvant PD-1 blockade in resectable lung cancer, N Engl J Med, 378, 1976, 10.1056/NEJMoa1716078 Shu, 2020, Neoadjuvant atezolizumab and chemotherapy in patients with resectable non-small-cell lung cancer: an open-label, multicentre, single-arm, phase 2 trial, Lancet Oncol, 21, 786, 10.1016/S1470-2045(20)30140-6 Rothschild, 2020, SAKK 16/14: Anti-PD-L1 antibody durvalumab in addition to neoadjuvant chemotherapy in patients with stage IIIA(N2) non-small cell lung cancer (NSCLC)—a multicenter single-arm phase II trial, J Clin Oncol, 38, 9016, 10.1200/JCO.2020.38.15_suppl.9016 Provencio, 2020, Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial, Lancet Oncol, 21, 10.1016/S1470-2045(20)30453-8 Spicer, 2021, Surgical outcomes from the phase 3 CheckMate 816 trial: Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo alone as neoadjuvant treatment for patients with resectable non-small cell lung cancer (NSCLC), J Clin Oncol, 39, 8503, 10.1200/JCO.2021.39.15_suppl.8503 Wakelee, 2021, IMpower010: primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in resected stage IB-IIIA non-small cell lung cancer (NSCLC), J Clin Oncol, 39, 8500, 10.1200/JCO.2021.39.15_suppl.8500 Fruh, 2019, Multimodal treatment in operable stage III NSCLC: a pooled analysis on long-term results of three SAKK trials (SAKK 16/96, 16/00, and 16/01), J Thorac Oncol, 14, 115, 10.1016/j.jtho.2018.09.011 Eberhardt, 2013, Lung Cancer, 82, 83, 10.1016/j.lungcan.2013.06.007 Martini, 1995, Mediastinal lymph node dissection for lung cancer. The Memorial experience, Chest Surg Clin N Am, 5, 189 Katakami, 2012, A phase 3 study of induction treatment with concurrent chemoradiotherapy versus chemotherapy before surgery in patients with pathologically confirmed N2 stage IIIA nonsmall cell lung cancer (WJTOG9903), Cancer, 118, 6126, 10.1002/cncr.26689 Pottgen, 2015, Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factors, BMC Cancer, 15, 363, 10.1186/s12885-015-1389-4 Eberhardt, 2015, Phase III study of surgery versus definitive concurrent chemoradiotherapy boost in patients with resectable stage IIIA(N2) and selected IIIB non-small-cell lung cancer after induction chemotherapy and concurrent chemoradiotherapy (ESPATUE), J Clin Oncol, 33, 4194, 10.1200/JCO.2015.62.6812 Bradley, 2020, Long-term results of NRG oncology RTOG 0617: standard- versus high-dose chemoradiotherapy with or without cetuximab for unresectable stage III non-small-cell lung cancer, J Clin Oncol, 38, 706, 10.1200/JCO.19.01162 Rosell, 1994, A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer, N Engl J Med, 330, 153, 10.1056/NEJM199401203300301 Johnstone, 2002, Int J Radiat Oncol Biol Phys, 54, 365, 10.1016/S0360-3016(02)02943-7 Stephens, 2005, Medical Research Council Lung Cancer Working Party. A randomised controlled trial of pre-operative chemotherapy followed, if feasible, by resection versus radiotherapy in patients with inoperable stage T3, N1, M0 or T1-3, N2, M0 non-small cell lung cancer, Lung Cancer, 49, 395, 10.1016/j.lungcan.2005.04.001 Albain, 2009, Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial, Lancet, 374, 379, 10.1016/S0140-6736(09)60737-6 van Meerbeeck, 2007, Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer, J Natl Cancer Inst, 99, 442, 10.1093/jnci/djk093 Thomas, 2008, Effect of preoperative chemoradiation in addition to preoperative chemotherapy: a randomised trial in stage III non-small-cell lung cancer, Lancet Oncol, 9, 636, 10.1016/S1470-2045(08)70156-6