Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
Lei Lv1,2,3, Dong Li4, Di Zhao2,3, Ruiting Lin2,3, Yajing Chu5, Heng Zhang1,2,3, Zhengyu Zha2, Ying Liu6, Zi Li7, Yanping Xu2,3, Gang Wang5, Yiran Huang4, Yue Xiong2,3,8, Kun-Liang Guan1,2,9, Qun-Ying Lei1,2
1Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology
2Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China,
3School of Life Science, Fudan University, Shanghai 200433, China
4Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai 200127, China
5Institute of Biochemistry and Cell Biology
6Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
7Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
8Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
9Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093-0815, USA
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Molecular Cell
Tập 42
719-730
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