Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection

Aagaard, 1999, Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31, EMBO J., 18, 1923, 10.1093/emboj/18.7.1923 Cao, 2005, Identification of an essential molecular contact point on the duck hepatitis B virus reverse transcriptase, J. Virol., 79, 10164, 10.1128/JVI.79.16.10164-10170.2005 Chen, 2010, MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output, EMBO J., 29, 2538, 10.1038/emboj.2010.140 Cheutin, 2003, Maintenance of stable heterochromatin domains by dynamic HP1 binding, Science, 299, 721, 10.1126/science.1078572 Cohen, 2004, Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase, Science, 305, 390, 10.1126/science.1099196 Dignam, 1983, Eukaryotic gene transcription with purified components, Methods Enzymol., 101, 582, 10.1016/0076-6879(83)01039-3 El Ramy, 2009, Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes, Cell. Mol. Life Sci., 66, 3219, 10.1007/s00018-009-0105-4 Festenstein, 2003, Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells, Science, 299, 719, 10.1126/science.1078694 García-Cao, 2004, Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases, Nat. Genet., 36, 94, 10.1038/ng1278 Guarente, 2005, Calorie restriction—the SIR2 connection, Cell, 120, 473, 10.1016/j.cell.2005.01.029 Heydari, 2007, Caloric restriction and genomic stability, Nucleic Acids Res., 35, 7485, 10.1093/nar/gkm860 Horn, 2005, A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation, Genes Dev., 19, 1705, 10.1101/gad.1328005 Imai, 2000, Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase, Nature, 403, 795, 10.1038/35001622 Jia, 2005, Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin, Nat. Cell Biol., 7, 1007, 10.1038/ncb1300 Jones, 2000, Mammalian chromodomain proteins: their role in genome organisation and expression, Bioessays, 22, 124, 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E Krouwels, 2005, A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain, J. Cell Biol., 170, 537, 10.1083/jcb.200502154 Kwon, 2008, The ups and downs of SIRT1, Trends Biochem. Sci., 33, 517, 10.1016/j.tibs.2008.08.001 Lyakhovich, 2003, Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response, Mol. Cell. Biol., 23, 2463, 10.1128/MCB.23.7.2463-2475.2003 Marine, 2010, Mdm2-mediated ubiquitylation: p53 and beyond, Cell Death Differ., 17, 93, 10.1038/cdd.2009.68 Martens, 2005, The profile of repeat-associated histone lysine methylation states in the mouse epigenome, EMBO J., 24, 800, 10.1038/sj.emboj.7600545 Melcher, 2000, Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression, Mol. Cell. Biol., 20, 3728, 10.1128/MCB.20.10.3728-3741.2000 Murayama, 2008, Epigenetic control of rDNA loci in response to intracellular energy status, Cell, 133, 627, 10.1016/j.cell.2008.03.030 Nandi, 2006, The ubiquitin-proteasome system, J. Biosci., 31, 137, 10.1007/BF02705243 Oberdoerffer, 2008, SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging, Cell, 135, 907, 10.1016/j.cell.2008.10.025 Peters, 2001, Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability, Cell, 107, 323, 10.1016/S0092-8674(01)00542-6 Saunders, 2007, Sirtuins: critical regulators at the crossroads between cancer and aging, Oncogene, 26, 5489, 10.1038/sj.onc.1210616 Schotta, 2002, Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing, EMBO J., 21, 1121, 10.1093/emboj/21.5.1121 Vaquero, 2009, The conserved role of sirtuins in chromatin regulation, Int. J. Dev. Biol., 53, 303, 10.1387/ijdb.082675av Vaquero, 2009, Calorie restriction and the exercise of chromatin, Genes Dev., 23, 1849, 10.1101/gad.1807009 Vaquero, 2004, Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin, Mol. Cell, 16, 93, 10.1016/j.molcel.2004.08.031 Vaquero, 2007, SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation, Nature, 450, 440, 10.1038/nature06268 Wang, 2008, Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice, Cancer Cell, 14, 312, 10.1016/j.ccr.2008.09.001 White, 1999, Photobleaching GFP reveals protein dynamics inside live cells, Trends Cell Biol., 9, 61, 10.1016/S0962-8924(98)01433-0 Zofall, 2007, HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast, J. Biol. Chem., 282, 14065, 10.1074/jbc.M700292200