Cerebral function in diabetes mellitus

Springer Science and Business Media LLC - Tập 37 - Trang 643-650 - 1994
G. J. Biessels1, A. C. Kappelle1, B. Bravenboer2, D. W. Erkelens3, W. H. Gispen1
1Department of Medical Pharmacology, Rudolf Magnus Institute, University of Utrecht, GD Utrecht, The Netherlands
2Division of Internal Medicine, Catharina Hospital, Eindhoven, The Netherlands
3Department of Internal Medicine, Academic Hospital, Utrecht, The Netherlands

Tóm tắt

Diabetes mellitus is a common metabolic disorder associated with chronic complications such as nephropathy, angiopathy, retinopathy and peripheral neuropathy. Diabetes is not often considered to have deleterious effects on the brain. However, long-term diabetes results in a variety of subtle cerebral disorders, which occur more frequently than is commonly believed. Diabetic cerebral disorders have been demonstrated at a neurochemical, electrophysiological, structural and cognitive level; however, the pathogenesis is still not clear. Probably alterations in cerebral blood supply and metabolic derangements play a role, as they do in the pathogenesis of diabetic neuropathy. Furthermore, the brain is also affected by recurrent episodes of hypoglycaemia and poor metabolic control. We describe herein the cerebral manifestations of diabetes and discuss the putative pathogenetic mechanisms.

Tài liệu tham khảo

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