Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress

Mitochondrion - Tập 20 - Trang 22-33 - 2015
Inês Marques-Aleixo1, Estela Santos-Alves1,2, Diogo Mariani1, David Rizo-Roca3, Ana I. Padrão4, Sílvia Rocha-Rodrigues1, Ginés Viscor3, J. Ramon Torrella3, Rita Ferreira4, Paulo J. Oliveira2, José Magalhães1, António Ascensão1
1CIAFEL — Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal
2CNC - Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal
3Department of Physiology and Immunology, Faculty of Biology, University of Barcelona, Spain
4QOPNA, Chemistry Department, University of Aveiro, Portugal

Tài liệu tham khảo

Abd El-Gawad, 2004, Nitric oxide and oxidative stress in brain and heart of normal rats treated with doxorubicin: role of aminoguanidine, J. Biochem. Mol. Toxicol., 18, 69, 10.1002/jbt.20013 Ascensao, 2005, Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice, Int. J. Cardiol., 100, 451, 10.1016/j.ijcard.2004.11.004 Ascensao, 2005, Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis, Am. J. Physiol. Heart Circ. Physiol., 289, H722, 10.1152/ajpheart.01249.2004 Ascensao, 2006, Effects of endurance training and acute doxorubicin treatment on rat heart mitochondrial alterations induced by in vitro anoxia-reoxygenation, Cardiovasc. Toxicol., 6, 159, 10.1385/CT:6:3:159 Ascensao, 2006, Endurance exercise training attenuates morphological signs of cardiac muscle damage induced by doxorubicin in male mice, Basic Appl. Myol., 16, 27 Ascensao, 2006, Endurance training limits the functional alterations of rat heart mitochondria submitted to in vitro anoxia-reoxygenation, Int. J. Cardiol., 109, 169, 10.1016/j.ijcard.2005.06.003 Ascensao, 2007, Exercise-induced cardioprotection—biochemical, morphological and functional evidence in whole tissue and isolated mitochondria, Int. J. Cardiol., 117, 16, 10.1016/j.ijcard.2006.04.076 Ascensao, 2011, Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats, Clin. Sci. (Lond.), 120, 37, 10.1042/CS20100254 Ascensao, 2011, Mitochondria as a target for exercise-induced cardioprotection, Curr. Drug Targets, 12, 860, 10.2174/138945011795529001 Ashour, 2012, Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats, Oxidative Med. Cell. Longev., 2012, 434195, 10.1155/2012/434195 Bell, 2011, The SirT3 divining rod points to oxidative stress, Mol. Cell, 42, 561, 10.1016/j.molcel.2011.05.008 Berthiaume, 2007, Adriamycin-induced oxidative mitochondrial cardiotoxicity, Cell Biol. Toxicol., 23, 15, 10.1007/s10565-006-0140-y Berthiaume, 2005, Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction, Cardiovasc. Toxicol., 5, 257, 10.1385/CT:5:3:257 Bhattacharya, 1991, Isolation of skeletal muscle mitochondria from hamsters using an ionic medium containing ethylenediaminetetraacetic acid and nagarse, Anal. Biochem., 192, 344, 10.1016/0003-2697(91)90546-6 Bianchi, 1987, Effect of adriamycin on electron transport in rat heart, liver, and tumor mitochondria, Exp. Mol. Pathol., 46, 123, 10.1016/0014-4800(87)90036-0 Brenmoehl, 2013, Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3, Mitochondrion, 13, 755, 10.1016/j.mito.2013.04.002 Buege, 1978, Microsomal lipid peroxidation, Methods Enzymol., 52, 302, 10.1016/S0076-6879(78)52032-6 Chicco, 2005, Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart, Am. J. Physiol. Regul. Integr. Comp. Physiol., 289, R424, 10.1152/ajpregu.00636.2004 Chicco, 2006, Exercise training attenuates acute doxorubicin-induced cardiac dysfunction, J. Cardiovasc. Pharmacol., 47, 182, 10.1097/01.fjc.0000199682.43448.2d Coore, 1971, Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones, Biochem. J., 125, 115, 10.1042/bj1250115 Davies, 1986, Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase, J. Biol. Chem., 261, 3060, 10.1016/S0021-9258(17)35746-0 Dolinsky, 2013, Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice, Am. J. Physiol. Endocrinol. Metab., 305, E243, 10.1152/ajpendo.00044.2013 Doroshow, 1986, Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical, J. Biol. Chem., 261, 3068, 10.1016/S0021-9258(17)35747-2 Doyle, 2006, Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices, CA Cancer J. Clin., 56, 323, 10.3322/canjclin.56.6.323 Emter, 2008, Curing the cure: utilizing exercise to limit cardiotoxicity, Med. Sci. Sports Exerc., 40, 806, 10.1249/MSS.0b013e3181684d03 Estabrook, 1967, Mitochondrial respiratory control and the polarographic measurement of ADP/O ratios, Meth. Enzymol., 10, 41, 10.1016/0076-6879(67)10010-4 Guo, 2009, p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes, Circ. Res., 104, 660, 10.1161/CIRCRESAHA.108.186288 Hayward, 2012, Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model, Pediatr. Blood Cancer, 59, 149, 10.1002/pbc.23392 Holloszy, 1970, Mitochondrial citric acid cycle and related enzymes: adaptive response to exercise, Biochem. Biophys. Res. Commun., 40, 1368, 10.1016/0006-291X(70)90017-3 Hoshino, 2013, Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart, Nat. Commun., 4, 2308, 10.1038/ncomms3308 Hu, 1990, Measurement of protein thiol groups and GSH in plasma, 380 Hydock, 2012, Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity, Exp. Biol. Med., 237, 1483, 10.1258/ebm.2012.012137 Hydock, 2012, Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity, Exp. Biol. Med. (Maywood), 237, 1483, 10.1258/ebm.2012.012137 Janssen, 2007, Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts, Clin. Chem., 53, 729, 10.1373/clinchem.2006.078873 Ji, 2006, Exercise and hormesis: activation of cellular antioxidant signaling pathway, Ann. N. Y. Acad. Sci., 1067, 425, 10.1196/annals.1354.061 Ji, 2007, Role of nuclear factor kappaB and mitogen-activated protein kinase signaling in exercise-induced antioxidant enzyme adaptation, Appl. Physiol. Nutr. Metab., 32, 930, 10.1139/H07-098 Jones, 2006, Diet, exercise, and complementary therapies after primary treatment for cancer, Lancet Oncol., 7, 1017, 10.1016/S1470-2045(06)70976-7 Kamo, 1979, Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state, J. Membr. Biol., 49, 105, 10.1007/BF01868720 Kong, 2010, Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis, PLoS ONE, 5, e11707, 10.1371/journal.pone.0011707 Lee, 2012, Exercise protects cardiac mitochondria against ischemia–reperfusion injury, Med. Sci. Sports Exerc., 44, 397, 10.1249/MSS.0b013e318231c037 Li, 2013, Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers, J. Hematol. Oncol., 6, 19, 10.1186/1756-8722-6-19 Lucia, 2003, Cancer-related fatigue: can exercise physiology assist oncologists?, Lancet Oncol., 4, 616, 10.1016/S1470-2045(03)01221-X Marques-Aleixo, 2012, In vitro salicylate does not further impair aging-induced brain mitochondrial dysfunction, Toxicology, 302, 51, 10.1016/j.tox.2012.07.018 Nulton-Persson, 2001, Modulation of mitochondrial function by hydrogen peroxide, J. Biol. Chem., 276, 23357, 10.1074/jbc.M100320200 Oliveira, 2006, Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats—relevance for mitochondrial dysfunction, Toxicology, 220, 160, 10.1016/j.tox.2005.12.009 Oliveira, 2006, Doxorubicin-induced thiol-dependent alteration of cardiac mitochondrial permeability transition and respiration, Biochemistry (Mosc), 71, 194, 10.1134/S000629790602012X Pereira, 2011, Drug-induced cardiac mitochondrial toxicity and protection: from doxorubicin to carvedilol, Curr. Pharm. Des., 17, 2113, 10.2174/138161211796904812 Pinton, 2008, p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria, Cell Cycle, 7, 304, 10.4161/cc.7.3.5360 Powers, 2008, Exercise-induced cardioprotection against myocardial ischemia–reperfusion injury, Free Radic. Biol. Med., 44, 193, 10.1016/j.freeradbiomed.2007.02.006 Sack, 2011, Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart, Am. J. Physiol. Heart Circ. Physiol., 301, H2191, 10.1152/ajpheart.00199.2011 Santos, 2002, Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy, Toxicol. Appl. Pharmacol., 185, 218, 10.1006/taap.2002.9532 Schagger, 1991, Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form, Anal. Biochem., 199, 223, 10.1016/0003-2697(91)90094-A Simon, 2003, Tacrolimus and sirolimus decrease oxidative phosphorylation of isolated rat kidney mitochondria, Br. J. Pharmacol., 138, 369, 10.1038/sj.bjp.0705038 Wallace, 2007, Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis, Cardiovasc. Toxicol., 7, 101, 10.1007/s12012-007-0008-2 Wonders, 2008, Acute exercise protects against doxorubicin cardiotoxicity, Integr. Cancer Ther., 7, 147, 10.1177/1534735408322848 Zerbetto, 1997, Quantification of muscle mitochondrial oxidative phosphorylation enzymes via histochemical staining of blue native polyacrylamide gels, Electrophoresis, 18, 2059, 10.1002/elps.1150181131 Zhou, 2001, Doxorubicin-induced persistent oxidative stress to cardiac myocytes, Toxicol. Lett., 121, 151, 10.1016/S0378-4274(01)00329-0 Zhou, 2001, Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin, Cancer Res., 61, 771