Co-Exposure to Cigarette Smoke and Alcohol Decreases Airway Epithelial Cell Cilia Beating in a Protein Kinase Cε-Dependent Manner

2010, Vital signs: current cigarette smoking among adults aged >or=18 years — United States, 2009, MMWR Morb Mortal Wkly Rep, 59, 1135 Simet, 2010, Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function, Am J Respir Cell Mol Biol, 43, 635, 10.1165/rcmb.2009-0297OC Coote, 2004, Mucociliary clearance is enhanced in rat models of cigarette smoke and lipopolysaccharide-induced lung disease, Exp Lung Res, 30, 59, 10.1080/01902140490252885 Wyatt, 2001, Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells, Am J Physiol Lung Cell Mol Physiol, 281, L575, 10.1152/ajplung.2001.281.3.L575 Vander Top, 2005, Smoke exposure exacerbates an ethanol-induced defect in mucociliary clearance of Streptococcus pneumoniae, Alcohol Clin Exp Res, 29, 882, 10.1097/01.ALC.0000164364.35682.86 Elliott, 2007, Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment, Am J Respir Cell Mol Biol, 36, 452, 10.1165/rcmb.2005-0440OC Wyatt, 1998, Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells, Am J Physiol, 275, L827 Salathe, 1993, Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating, J Cell Sci, 106, 1211, 10.1242/jcs.106.4.1211 Fishaut, 1978, Behavior of respiratory syncytial virus in piglet tracheal organ culture, J Infect Dis, 138, 644, 10.1093/infdis/138.5.644 O'Brien, 2004, Ophiopogon root (Radix Ophiopogonis) prevents ultra-structural damage by SO2 in an epithelial injury model for studies of mucociliary transport, Life Sci, 74, 2413, 10.1016/j.lfs.2003.09.067 Wyatt, 2008, Exposure to hog barn dust alters airway epithelial ciliary beating, Eur Respir J, 31, 1249, 10.1183/09031936.00015007 Chen, 2000, Modulation of ciliary activity by tumor necrosis factor-alpha in cultured sinus epithelial cells, Hiroshima J Med Sci, 49, 49 Sisson, 1994, Vapor phase exposure to acetaldehyde generated from ethanol inhibits bovine bronchial epithelial cell ciliary motility, Alcohol Clin Exp Res, 18, 1252, 10.1111/j.1530-0277.1994.tb00114.x Wong, 1998, Neuropeptide Y inhibits ciliary beat frequency in human ciliated cells via nPKC, independently of PKA, Am J Physiol, 275, C440, 10.1152/ajpcell.1998.275.2.C440 Wyatt, 1997, Stimulation of protein kinase C activity by tumor necrosis factor-alpha in bovine bronchial epithelial cells, Am J Physiol, 273, L1007 Slager, 2007, Hog barn dust slows airway epithelial cell migration in vitro through a PKC{alpha}-dependent mechanism, Am J Physiol Lung Cell Mol Physiol, 293, L1469, 10.1152/ajplung.00274.2007 Hastie, 1986, Isolation of cilia from porcine tracheal epithelium and extraction of dynein arms, Cell Motil Cytoskel, 6, 25, 10.1002/cm.970060105 Wyatt, 2005, Both cAMP and cGMP are required for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemes, Am J Physiol Lung Cell Mol Physiol, 288, L546, 10.1152/ajplung.00107.2004 Wyatt, 2000, Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes, Proc Soc Exp Biol Med, 225, 91, 10.1046/j.1525-1373.2000.22511.x Wyatt, 2003, Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells, Am J Pathol, 163, 1157, 10.1016/S0002-9440(10)63475-X Thrower, 2009, Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini, Pancreas, 38, 930, 10.1097/MPA.0b013e3181b8476a Wyatt, 2012, Malondialdehyde-acetaldehyde-adducted protein inhalation causes lung injury, Alcohol, 46, 51, 10.1016/j.alcohol.2011.09.001 Delmotte, 2006, Ciliary beat frequency is maintained at a maximal rate in the small airways of mouse lung slices, Am J Respir Cell Mol Biol, 35, 110, 10.1165/rcmb.2005-0417OC Sisson, 2003, All-digital image capture and whole-field analysis of ciliary beat frequency, J Microsc, 211, 103, 10.1046/j.1365-2818.2003.01209.x Wyatt, 2010, Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor, Am J Respir Cell Mol Biol, 42, 706, 10.1165/rcmb.2009-0065OC Satoh, 2004, PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells, Am J Physiol Gastrointest Liver Physiol, 287, G582, 10.1152/ajpgi.00087.2004 Stout, 2007, Nitric oxide-dependent cilia regulatory enzyme localization in bovine bronchial epithelial cells, J Histochem Cytochem, 55, 433, 10.1369/jhc.6A7089.2007 Slager, 2006, Inhibition of protein kinase C epsilon causes ciliated bovine bronchial cell detachment, Exp Lung Res, 32, 349, 10.1080/01902140600959630 Zhao, 2006, Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, J Biol Chem, 281, 19501, 10.1074/jbc.M511224200 Slager, 2008, RACK1, a PKC targeting protein, is exclusively localized to basal airway epithelial cells, J Histochem Cytochem, 56, 7, 10.1369/jhc.7A7249.2007 Navarette, 2012, Particulate matter in cigarette smoke increases ciliary axoneme beating through mechanical stimulation, J Aerosol Med Pulm Drug Deliv, 10.1089/jamp.2011.0890 McCaskill, 2011, Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke, Alcohol Clin Exp Res, 35, 1106, 10.1111/j.1530-0277.2011.01443.x Wyatt, 2005, Malondialdehyde-acetaldehyde adducts decrease bronchial epithelial wound repair, Alcohol, 36, 31, 10.1016/j.alcohol.2005.06.002 Sisson, 1995, Ethanol stimulates apparent nitric oxide-dependent ciliary beat frequency in bovine airway epithelial cells, Am J Physiol, 268, L596 Wyatt, 2004, Desensitization of PKA-stimulated ciliary beat frequency in an ethanol-fed rat model of cigarette smoke exposure, Alcohol Clin Exp Res, 28, 998, 10.1097/01.ALC.0000130805.75641.F4 Miller, 1998, Comorbid cigarette and alcohol addiction: epidemiology and treatment, J Addict Dis, 17, 55, 10.1300/J069v17n01_06 Sisson, 2005, Alcohol intake is associated with altered pulmonary function, Alcohol, 36, 19, 10.1016/j.alcohol.2005.05.002 Gamble, 2006, The effects of alcohol on immunity and bacterial infection in the lung, Med Mal Infect, 36, 72, 10.1016/j.medmal.2005.08.010