AMPARs and Synaptic Plasticity: The Last 25 Years

Adesnik, 2007, Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation, J. Neurosci., 27, 4598, 10.1523/JNEUROSCI.0325-07.2007 Anggono, 2012, Regulation of AMPA receptor trafficking and synaptic plasticity, Curr. Opin. Neurobiol., 22, 461, 10.1016/j.conb.2011.12.006 Aoto, 2013, Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking, Cell, 154, 75, 10.1016/j.cell.2013.05.060 Ascher, 1988, The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture, J. Physiol., 399, 247, 10.1113/jphysiol.1988.sp017078 Barria, 2005, NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII, Neuron, 48, 289, 10.1016/j.neuron.2005.08.034 Barria, 1997, Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation, Science, 276, 2042, 10.1126/science.276.5321.2042 Beattie, 2000, Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD, Nat. Neurosci., 3, 1291, 10.1038/81823 Béïque, 2003, PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex, J. Physiol., 546, 859, 10.1113/jphysiol.2002.031369 Béïque, 2006, Synapse-specific regulation of AMPA receptor function by PSD-95, Proc. Natl. Acad. Sci. USA, 103, 19535, 10.1073/pnas.0608492103 Benke, 1998, Modulation of AMPA receptor unitary conductance by synaptic activity, Nature, 393, 793, 10.1038/31709 Blackstone, 1992, Immunological detection of glutamate receptor subtypes in human central nervous system, Ann. Neurol., 31, 680, 10.1002/ana.410310620 Blackstone, 1994, Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors, J. Neurosci., 14, 7585, 10.1523/JNEUROSCI.14-12-07585.1994 Bliss, 2013, Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide, Mol. Brain, 6, 5, 10.1186/1756-6606-6-5 Bliss, 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol., 232, 331, 10.1113/jphysiol.1973.sp010273 Boehm, 2006, Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1, Neuron, 51, 213, 10.1016/j.neuron.2006.06.013 Borgdorff, 2002, Regulation of AMPA receptor lateral movements, Nature, 417, 649, 10.1038/nature00780 Bredt, 2003, AMPA receptor trafficking at excitatory synapses, Neuron, 40, 361, 10.1016/S0896-6273(03)00640-8 Cai, 2013, Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression, Nat. Neurosci., 16, 464, 10.1038/nn.3355 Carroll, 1999, Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures, Nat. Neurosci., 2, 454, 10.1038/8123 Chen, 2000, Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms, Nature, 408, 936, 10.1038/35050030 Cho, 1992, The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein, Neuron, 9, 929, 10.1016/0896-6273(92)90245-9 Chung, 2000, Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins, J. Neurosci., 20, 7258, 10.1523/JNEUROSCI.20-19-07258.2000 Chung, 2003, Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression, Science, 300, 1751, 10.1126/science.1082915 Citri, 2010, Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression, J. Neurosci., 30, 16437, 10.1523/JNEUROSCI.4478-10.2010 Collingridge, 1983, Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus, J. Physiol., 334, 33, 10.1113/jphysiol.1983.sp014478 Collingridge, 2004, Receptor trafficking and synaptic plasticity, Nat. Rev. Neurosci., 5, 952, 10.1038/nrn1556 Collingridge, 2010, Long-term depression in the CNS, Nat. Rev. Neurosci., 11, 459, 10.1038/nrn2867 Coombs, 2009, Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum, Neuroscience, 162, 656, 10.1016/j.neuroscience.2009.01.004 Coombs, 2012, Cornichons modify channel properties of recombinant and glial AMPA receptors, J. Neurosci., 32, 9796, 10.1523/JNEUROSCI.0345-12.2012 Coussen, 2009, Molecular determinants of kainate receptor trafficking, Neuroscience, 158, 25, 10.1016/j.neuroscience.2007.12.052 Craig, 2007, Neurexin-neuroligin signaling in synapse development, Curr. Opin. Neurobiol., 17, 43, 10.1016/j.conb.2007.01.011 Craig, 1993, The distribution of glutamate receptors in cultured rat hippocampal neurons: postsynaptic clustering of AMPA-selective subunits, Neuron, 10, 1055, 10.1016/0896-6273(93)90054-U de Wit, 2009, LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation, Neuron, 64, 799, 10.1016/j.neuron.2009.12.019 De Zeeuw, 1998, Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex, Neuron, 20, 495, 10.1016/S0896-6273(00)80990-3 Derkach, 1999, Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors, Proc. Natl. Acad. Sci. USA, 96, 3269, 10.1073/pnas.96.6.3269 Dev, 2000, PICK1 interacts with and regulates PKC phosphorylation of mGLUR7, J. Neurosci., 20, 7252, 10.1523/JNEUROSCI.20-19-07252.2000 Dong, 1997, GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors, Nature, 386, 279, 10.1038/386279a0 Dong, 1999, Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2, J. Neurosci., 19, 6930, 10.1523/JNEUROSCI.19-16-06930.1999 Dosemeci, 2010, Regulation of phosphorylation at the postsynaptic density during different activity states of Ca2+/calmodulin-dependent protein kinase II, Biochem. Biophys. Res. Commun., 391, 78, 10.1016/j.bbrc.2009.10.167 Dudek, 1992, Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade, Proc. Natl. Acad. Sci. USA, 89, 4363, 10.1073/pnas.89.10.4363 Ehlers, 2000, Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting, Neuron, 28, 511, 10.1016/S0896-6273(00)00129-X Ehrlich, 2004, Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity, J. Neurosci., 24, 916, 10.1523/JNEUROSCI.4733-03.2004 El-Husseini, 2000, PSD-95 involvement in maturation of excitatory synapses, Science, 290, 1364, 10.1126/science.290.5495.1364 Elias, 2006, Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins, Neuron, 52, 307, 10.1016/j.neuron.2006.09.012 Etherton, 2011, An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus, EMBO J., 30, 2908, 10.1038/emboj.2011.182 Gill, 2012, AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform, Eur. J. Neurosci., 35, 182, 10.1111/j.1460-9568.2011.07948.x Gomperts, 1998, Postsynaptically silent synapses in single neuron cultures, Neuron, 21, 1443, 10.1016/S0896-6273(00)80662-5 Granger, 2013, LTP requires a reserve pool of glutamate receptors independent of subunit type, Nature, 493, 495, 10.1038/nature11775 Halt, 2012, CaMKII binding to GluN2B is critical during memory consolidation, EMBO J., 31, 1203, 10.1038/emboj.2011.482 Hansel, 2000, Long-term depression of the cerebellar climbing fiber—Purkinje neuron synapse, Neuron, 26, 473, 10.1016/S0896-6273(00)81179-4 Harvey, 2007, Locally dynamic synaptic learning rules in pyramidal neuron dendrites, Nature, 450, 1195, 10.1038/nature06416 Hayashi, 2000, Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction, Science, 287, 2262, 10.1126/science.287.5461.2262 Hayashi, 2009, Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking, Neuron, 64, 213, 10.1016/j.neuron.2009.08.017 Herring, 2013, Cornichon proteins determine the subunit composition of synaptic AMPA receptors, Neuron, 77, 1083, 10.1016/j.neuron.2013.01.017 Howard, 2010, The role of SAP97 in synaptic glutamate receptor dynamics, Proc. Natl. Acad. Sci. USA, 107, 3805, 10.1073/pnas.0914422107 Hu, 2007, Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking, Cell, 131, 160, 10.1016/j.cell.2007.09.017 Isaac, 1995, Evidence for silent synapses: implications for the expression of LTP, Neuron, 15, 427, 10.1016/0896-6273(95)90046-2 Ito, 1982, Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells, J. Physiol., 324, 113, 10.1113/jphysiol.1982.sp014103 Ito-Ishida, 2012, Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation, Neuron, 76, 549, 10.1016/j.neuron.2012.07.027 Jaafari, 2012, PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking, J. Neurosci., 32, 11618, 10.1523/JNEUROSCI.5068-11.2012 Jackson, 2011, The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits, Neuron, 70, 178, 10.1016/j.neuron.2011.04.007 Jahr, 1987, Glutamate activates multiple single channel conductances in hippocampal neurons, Nature, 325, 522, 10.1038/325522a0 Jurado, 2010, A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression, Nat. Neurosci., 13, 1053, 10.1038/nn.2613 Jurado, 2013, LTP requires a unique postsynaptic SNARE fusion machinery, Neuron, 77, 542, 10.1016/j.neuron.2012.11.029 Kalashnikova, 2010, SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development, Neuron, 65, 80, 10.1016/j.neuron.2009.12.021 Kameyama, 1998, Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression, Neuron, 21, 1163, 10.1016/S0896-6273(00)80633-9 Kashiwabuchi, 1995, Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice, Cell, 81, 245, 10.1016/0092-8674(95)90334-8 Kato, 2010, TARPs differentially decorate AMPA receptors to specify neuropharmacology, Trends Neurosci., 33, 241, 10.1016/j.tins.2010.02.004 Kessels, 2009, Synaptic AMPA receptor plasticity and behavior, Neuron, 61, 340, 10.1016/j.neuron.2009.01.015 Kim, 2001, Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression, Proc. Natl. Acad. Sci. USA, 98, 11725, 10.1073/pnas.211132798 Kim, 2011, PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility, Nat. Neurosci., 14, 1447, 10.1038/nn.2937 Kohda, 2013, The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites, Proc. Natl. Acad. Sci. USA, 110, E948, 10.1073/pnas.1218380110 Kornau, 1995, Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95, Science, 269, 1737, 10.1126/science.7569905 Kristensen, 2011, Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating, Nat. Neurosci., 14, 727, 10.1038/nn.2804 Krueger, 2012, The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses, Curr. Opin. Neurobiol., 22, 412, 10.1016/j.conb.2012.02.012 Lee, 1998, NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus, Neuron, 21, 1151, 10.1016/S0896-6273(00)80632-7 Lee, 2000, Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity, Nature, 405, 955, 10.1038/35016089 Lee, 2003, Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory, Cell, 112, 631, 10.1016/S0092-8674(03)00122-3 Lee, 2004, Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons, Neuron, 43, 221, 10.1016/j.neuron.2004.06.015 Lee, 2009, Activation of CaMKII in single dendritic spines during long-term potentiation, Nature, 458, 299, 10.1038/nature07842 Lee, 2010, Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus, J. Neurophysiol., 103, 479, 10.1152/jn.00835.2009 Leonard, 1998, SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit, J. Biol. Chem., 273, 19518, 10.1074/jbc.273.31.19518 Liao, 1995, Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice, Nature, 375, 400, 10.1038/375400a0 Liao, 1999, Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons, Nat. Neurosci., 2, 37, 10.1038/4540 Liao, 2001, Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors, J. Neurosci., 21, 6008, 10.1523/JNEUROSCI.21-16-06008.2001 Lin, 2009, Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation, Nat. Neurosci., 12, 879, 10.1038/nn.2351 Linden, 1994, Input-specific induction of cerebellar long-term depression does not require presynaptic alteration, Learn. Mem., 1, 121, 10.1101/lm.1.2.121 Linden, 1991, Participation of postsynaptic PKC in cerebellar long-term depression in culture, Science, 254, 1656, 10.1126/science.1721243 Lisman, 1989, A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory, Proc. Natl. Acad. Sci. USA, 86, 9574, 10.1073/pnas.86.23.9574 Lisman, 2012, Mechanisms of CaMKII action in long-term potentiation, Nat. Rev. Neurosci., 13, 169, 10.1038/nrn3192 Lissin, 1998, Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors, Proc. Natl. Acad. Sci. USA, 95, 7097, 10.1073/pnas.95.12.7097 Lledo, 1998, Postsynaptic membrane fusion and long-term potentiation, Science, 279, 399, 10.1126/science.279.5349.399 Lomo, 1966, Frequency potentiation of excitatory synaptic activity in the dentate area of the hippocampal formation, Acta Physiol. Scand., 68, 128 Lu, 2012, Posttranslational regulation of AMPA receptor trafficking and function, Curr. Opin. Neurobiol., 22, 470, 10.1016/j.conb.2011.09.008 Lu, 2009, Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach, Neuron, 62, 254, 10.1016/j.neuron.2009.02.027 Lüscher, 2012, NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD), Cold Spring Harb. Perspect. Biol., 4, 4, 10.1101/cshperspect.a005710 Lüscher, 1999, Role of AMPA receptor cycling in synaptic transmission and plasticity, Neuron, 24, 649, 10.1016/S0896-6273(00)81119-8 Lynch, 1983, Intracellular injections of EGTA block induction of hippocampal long-term potentiation, Nature, 305, 719, 10.1038/305719a0 Makino, 2009, AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis, Neuron, 64, 381, 10.1016/j.neuron.2009.08.035 Makino, 2011, Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor, Proc. Natl. Acad. Sci. USA, 108, 8450, 10.1073/pnas.1105261108 Malenka, 2004, LTP and LTD: an embarrassment of riches, Neuron, 44, 5, 10.1016/j.neuron.2004.09.012 Malenka, 1989, An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation, Nature, 340, 554, 10.1038/340554a0 Malinow, 2002, AMPA receptor trafficking and synaptic plasticity, Annu. Rev. Neurosci., 25, 103, 10.1146/annurev.neuro.25.112701.142758 Malinow, 1986, Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiation, Nature, 320, 529, 10.1038/320529a0 Malinow, 1989, Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP, Science, 245, 862, 10.1126/science.2549638 Mammen, 1997, Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II, J. Biol. Chem., 272, 32528, 10.1074/jbc.272.51.32528 Matsuda, 1999, Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein, J. Neurochem., 73, 1765, 10.1046/j.1471-4159.1999.731765.x Matsuzaki, 2004, Structural basis of long-term potentiation in single dendritic spines, Nature, 429, 761, 10.1038/nature02617 Mayer, 1984, Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones, Nature, 309, 261, 10.1038/309261a0 McGlade-McCulloh, 1993, Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II, Nature, 362, 640, 10.1038/362640a0 Meng, 2003, Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3, Neuron, 39, 163, 10.1016/S0896-6273(03)00368-4 Milstein, 2008, Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits, Trends Pharmacol. Sci., 29, 333, 10.1016/j.tips.2008.04.004 Molnár, 1993, Biochemical and immunocytochemical characterization of antipeptide antibodies to a cloned GluR1 glutamate receptor subunit: cellular and subcellular distribution in the rat forebrain, Neuroscience, 53, 307, 10.1016/0306-4522(93)90198-O Moss, 1993, Phosphorylation of recombinant non-NMDA glutamate receptors on serine and tyrosine residues, Neurochem. Res., 18, 105, 10.1007/BF00966929 Mulkey, 1992, Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus, Neuron, 9, 967, 10.1016/0896-6273(92)90248-C Mulkey, 1994, Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression, Nature, 369, 486, 10.1038/369486a0 Murakoshi, 2011, Local, persistent activation of Rho GTPases during plasticity of single dendritic spines, Nature, 472, 100, 10.1038/nature09823 Nabavi, 2013, Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression, Proc. Natl. Acad. Sci. USA, 110, 4027, 10.1073/pnas.1219454110 Nicolas, 2012, The Jak/STAT pathway is involved in synaptic plasticity, Neuron, 73, 374, 10.1016/j.neuron.2011.11.024 Nicoll, 2013, Long-term potentiation: Peeling the onion, Neuropharmacology, 74, 18, 10.1016/j.neuropharm.2013.02.010 Nicoll, 1988, The current excitement in long-term potentiation, Neuron, 1, 97, 10.1016/0896-6273(88)90193-6 Nishimune, 1998, NSF binding to GluR2 regulates synaptic transmission, Neuron, 21, 87, 10.1016/S0896-6273(00)80517-6 Nowak, 1984, Magnesium gates glutamate-activated channels in mouse central neurones, Nature, 307, 462, 10.1038/307462a0 O’Brien, 1998, Activity-dependent modulation of synaptic AMPA receptor accumulation, Neuron, 21, 1067, 10.1016/S0896-6273(00)80624-8 Opazo, 2011, A three-step model for the synaptic recruitment of AMPA receptors, Mol. Cell. Neurosci., 46, 1, 10.1016/j.mcn.2010.08.014 Opazo, 2012, Regulation of AMPA receptor surface diffusion by PSD-95 slots, Curr. Opin. Neurobiol., 22, 453, 10.1016/j.conb.2011.10.010 Osten, 1998, The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs, Neuron, 21, 99, 10.1016/S0896-6273(00)80518-8 Patterson, 2010, AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation, Proc. Natl. Acad. Sci. USA, 107, 15951, 10.1073/pnas.0913875107 Plant, 2006, Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation, Nat. Neurosci., 9, 602, 10.1038/nn1678 Renner, 2009, Control of the postsynaptic membrane viscosity, J. Neurosci., 29, 2926, 10.1523/JNEUROSCI.4445-08.2009 Renner, 2009, The excitatory postsynaptic density is a size exclusion diffusion environment, Neuropharmacology, 56, 30, 10.1016/j.neuropharm.2008.07.022 Rocca, 2013, The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity, Neuron, 79, 293, 10.1016/j.neuron.2013.05.003 Roche, 1996, Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit, Neuron, 16, 1179, 10.1016/S0896-6273(00)80144-0 Sanes, 1999, Development of the vertebrate neuromuscular junction, Annu. Rev. Neurosci., 22, 389, 10.1146/annurev.neuro.22.1.389 Santamaria, 2010, Quantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic density, PLoS Comput. Biol., 6, e1000780, 10.1371/journal.pcbi.1000780 Schlüter, 2006, Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function, Neuron, 51, 99, 10.1016/j.neuron.2006.05.016 Schwenk, 2009, Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors, Science, 323, 1313, 10.1126/science.1167852 Schwenk, 2012, High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes, Neuron, 74, 621, 10.1016/j.neuron.2012.03.034 Seidenman, 2003, Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells, J. Neurosci., 23, 9220, 10.1523/JNEUROSCI.23-27-09220.2003 Selcher, 2012, Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus, Brain Res., 1435, 8, 10.1016/j.brainres.2011.11.029 Seol, 2007, Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity, Neuron, 55, 919, 10.1016/j.neuron.2007.08.013 Shanks, 2012, Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L, Cell Rep., 1, 590, 10.1016/j.celrep.2012.05.004 Sheng, 2001, PDZ domains and the organization of supramolecular complexes, Annu. Rev. Neurosci., 24, 1, 10.1146/annurev.neuro.24.1.1 Shepherd, 2007, The cell biology of synaptic plasticity: AMPA receptor trafficking, Annu. Rev. Cell Dev. Biol., 23, 613, 10.1146/annurev.cellbio.23.090506.123516 Shi, 1999, Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation, Science, 284, 1811, 10.1126/science.284.5421.1811 Shi, 2001, Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons, Cell, 105, 331, 10.1016/S0092-8674(01)00321-X Shi, 2010, Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating, Proc. Natl. Acad. Sci. USA, 107, 16315, 10.1073/pnas.1011706107 Shipman, 2012, A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP, Neuron, 76, 309, 10.1016/j.neuron.2012.07.024 Shipman, 2011, Functional dependence of neuroligin on a new non-PDZ intracellular domain, Nat. Neurosci., 14, 718, 10.1038/nn.2825 Soderling, 1993, Calcium/calmodulin-dependent protein kinase II: role in learning and memory, Mol. Cell. Biochem., 127-128, 93, 10.1007/BF01076760 Soler-Llavina, 2011, The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo, Proc. Natl. Acad. Sci. USA, 108, 16502, 10.1073/pnas.1114028108 Soler-Llavina, 2013, Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation, Neuron, 79, 439, 10.1016/j.neuron.2013.06.007 Song, 1998, Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors, Neuron, 21, 393, 10.1016/S0896-6273(00)80548-6 Srivastava, 1999, ABP: a novel AMPA receptor binding protein, Ann. N Y Acad. Sci., 868, 561, 10.1111/j.1749-6632.1999.tb11329.x Steinberg, 2004, N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression, Proc. Natl. Acad. Sci. USA, 101, 18212, 10.1073/pnas.0408278102 Steinberg, 2006, Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression, Neuron, 49, 845, 10.1016/j.neuron.2006.02.025 Straub, 2012, The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits, Curr. Opin. Neurobiol., 22, 488, 10.1016/j.conb.2011.09.005 Südhof, 2008, Neuroligins and neurexins link synaptic function to cognitive disease, Nature, 455, 903, 10.1038/nature07456 Sumioka, 2010, TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers, Neuron, 66, 755, 10.1016/j.neuron.2010.04.035 Swope, 1992, Phosphorylation of ligand-gated ion channels: a possible mode of synaptic plasticity, FASEB J., 6, 2514, 10.1096/fasebj.6.8.1375568 Takamiya, 2008, The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells, J. Neurosci., 28, 5752, 10.1523/JNEUROSCI.0654-08.2008 Takumi, 1999, Different modes of expression of AMPA and NMDA receptors in hippocampal synapses, Nat. Neurosci., 2, 618, 10.1038/10172 Tan, 1994, Phosphorylation of AMPA-type glutamate receptors by calcium/calmodulin-dependent protein kinase II and protein kinase C in cultured hippocampal neurons, J. Neurosci., 14, 1123, 10.1523/JNEUROSCI.14-03-01123.1994 Terashima, 2008, An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity, Neuron, 57, 872, 10.1016/j.neuron.2008.01.028 Tomita, 2003, Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins, J. Cell Biol., 161, 805, 10.1083/jcb.200212116 Tomita, 2005, Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs, Neuron, 45, 269, 10.1016/j.neuron.2005.01.009 Traynelis, 2010, Glutamate receptor ion channels: structure, regulation, and function, Pharmacol. Rev., 62, 405, 10.1124/pr.109.002451 Turrigiano, 2008, The self-tuning neuron: synaptic scaling of excitatory synapses, Cell, 135, 422, 10.1016/j.cell.2008.10.008 Turrigiano, 1998, Activity-dependent scaling of quantal amplitude in neocortical neurons, Nature, 391, 892, 10.1038/36103 Volk, 2010, Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning, Proc. Natl. Acad. Sci. USA, 107, 21784, 10.1073/pnas.1016103107 von Engelhardt, 2010, CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus, Science, 327, 1518, 10.1126/science.1184178 Wang, 2000, Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis, Neuron, 25, 635, 10.1016/S0896-6273(00)81066-1 Wang, 2012, The SOL-2/Neto auxiliary protein modulates the function of AMPA-subtype ionotropic glutamate receptors, Neuron, 75, 838, 10.1016/j.neuron.2012.06.038 Wenthold, 1996, Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons, J. Neurosci., 16, 1982, 10.1523/JNEUROSCI.16-06-01982.1996 Wigström, 1986, Hippocampal long-term potentiation is induced by pairing single afferent volleys with intracellularly injected depolarizing current pulses, Acta Physiol. Scand., 126, 317, 10.1111/j.1748-1716.1986.tb07822.x Wyllie, 1994, A role for protein kinases and phosphatases in the Ca(2+)-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses, Neuron, 13, 635, 10.1016/0896-6273(94)90031-0 Xia, 1999, Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1, Neuron, 22, 179, 10.1016/S0896-6273(00)80689-3 Xu, 2011, PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity, Curr. Opin. Neurobiol., 21, 306, 10.1016/j.conb.2011.03.001 Xu, 2008, Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD, Neuron, 57, 248, 10.1016/j.neuron.2007.11.027 Yoshimura, 2000, Investigation of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II translocated to the postsynaptic density, Brain Res. Mol. Brain Res., 81, 118, 10.1016/S0169-328X(00)00170-4 Yoshimura, 2002, Identification of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry, Biochem. Biophys. Res. Commun., 290, 948, 10.1006/bbrc.2001.6320 Zheng, 2011, MAGUKs, synaptic development, and synaptic plasticity, Neuroscientist, 17, 493, 10.1177/1073858410386384 Zhou, 2007, Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning, J. Neurosci., 27, 13843, 10.1523/JNEUROSCI.4486-07.2007 Zhu, 2002, Ras and Rap control AMPA receptor trafficking during synaptic plasticity, Cell, 110, 443, 10.1016/S0092-8674(02)00897-8