Recompensa alimentar: mecanismos envolvidos e implicações para a obesidade

Gabriela Ribeiro1, Osvaldo Santos2
1Faculdade de Medicina de Lisboa, Lisboa, Portugal
2Instituto de Medicina Preventiva, Faculdade de Medicina de Lisboa, Lisboa, Portugal

Tài liệu tham khảo

do Carmo, 2009 Bray, 2004, Medical consequences of obesity, J Clin Endocrinol Metab, 89, 2583, 10.1210/jc.2004-0535 Raebel, 2004, Health services use and health care costs of obese and nonobese individuals, Arch Intern Med, 164, 2135, 10.1001/archinte.164.19.2135 Moreira, 2005, Obesidade: muito peso, várias medidas, Ambar Hill, 1998, Environmental contributions to the obesity epidemic, Science, 280, 1371, 10.1126/science.280.5368.1371 Nestle, 2000, Halting the obesity epidemic: A public health policy approach, Public Health Rep, 115 Levitsky, 2005, The non-regulation of food intake in humans: Hope for reversing the epidemic of obesity, Physiol Behav, 86, 623, 10.1016/j.physbeh.2005.08.053 Coll, 2007, The hormonal control of food intake, Cell, 129, 251, 10.1016/j.cell.2007.04.001 Murphy, 2006, Gut hormones and the regulation of energy homeostasis, Nature, 444, 854, 10.1038/nature05484 Morton, 2006, Central nervous system control of food intake and body weight, Nature, 443, 289, 10.1038/nature05026 Lutter, 2009, Homeostatic and hedonic signals interact in the regulation of food intake, J Nutr, 139, 629, 10.3945/jn.108.097618 Egecioglu, 2011, Hedonic and incentive signals for body weight control, Rev Endocr Metab Disord, 12, 141, 10.1007/s11154-011-9166-4 Saper, 2002, The need to feed: Homeostatic and hedonic control of eating, Neuron, 36, 199, 10.1016/S0896-6273(02)00969-8 Berthoud, 2004, Neural control of appetite: Cross-talk between homeostatic and non-homeostatic systems, Appetite, 43, 315, 10.1016/j.appet.2004.04.009 Berthoud, 2006, Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance, Obesity, 14, 197S, 10.1038/oby.2006.308 Kenny, 2011, Reward mechanisms in obesity: New insights and future directions, Neuron, 69, 664, 10.1016/j.neuron.2011.02.016 Lin, 2000, Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain, Brain Res, 875, 89, 10.1016/S0006-8993(00)02580-4 Huang, 2003, Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity, Brain Res, 992, 9, 10.1016/j.brainres.2003.08.019 Huang, 2004, Role of fat amount and type in ameliorating diet-induced obesity: Insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression, Diabetes Obes Metab, 6, 35, 10.1111/j.1463-1326.2004.00312.x Kaga, 2001, Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding, Diabetes, 50, 1206, 10.2337/diabetes.50.5.1206 Giraudo, 1994, Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 266, R1578, 10.1152/ajpregu.1994.266.5.R1578 Covasa, 2000, High fat maintenance diet attenuates hindbrain neuronal response to CCK, Regul Pept, 86, 83, 10.1016/S0167-0115(99)00084-1 Erlanson-Albertsson, 2005, How palatable food disrupts appetite regulation, Basic Clin Pharmacol Toxicol, 97, 61, 10.1111/j.1742-7843.2005.pto_179.x Sclafani, 2003, Reinforcement value of sucrose measured by progressive ratio operant licking in the rat, Physiol Behav, 79, 663, 10.1016/S0031-9384(03)00143-4 Sclafani, 2004, Oral and postoral determinants of food reward, Physiol Behav, 81, 773, 10.1016/j.physbeh.2004.04.031 Colantuoni, 2001, Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain, Neuroreport, 12, 3549, 10.1097/00001756-200111160-00035 Pomonis, 2000, Sucrose consumption increases naloxone-induced c-Fos immunoreactivity in limbic forebrain, Am J Physiol Regul Integr Comp Physiol, 278, R712, 10.1152/ajpregu.2000.278.3.R712 Welch, 1996, Palatability-induced hyperphagia increases hypothalamic Dynorphin peptide and mRNA levels, Brain Res, 721, 126, 10.1016/0006-8993(96)00151-5 Berthoud, 2008, The brain, appetite, and obesity, Annu Rev Psychol, 59, 55, 10.1146/annurev.psych.59.103006.093551 Davis, 2009, Compulsive overeating as an addiction disorder. A review of theory and evidence, Appetite, 53, 1, 10.1016/j.appet.2009.05.018 Petrovich, 2005, Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating, J Neurosci, 25, 8295, 10.1523/JNEUROSCI.2480-05.2005 Volkow, 2005, How can drug addiction help us understand obesity?, Nat Neurosci, 8, 555, 10.1038/nn1452 Hill, 2003, Obesity and the environment: Where do we go from here?, Science, 299, 853, 10.1126/science.1079857 Swinburn, 2009, Increased food energy supply is more than sufficient to explain the US epidemic of obesity, Am J Clin Nutr, 90, 1453, 10.3945/ajcn.2009.28595 Zheng, 2009, Appetite control and energy balance regulation in the modern world: Reward-driven brain overrides repletion signals, Int J Obes (Lond), 33, S8, 10.1038/ijo.2009.65 Shomaker, 2010, Eating in the absence of hunger in adolescents: Intake after a large-array meal compared with that after a standardized meal, Am J Clin Nutr, 92, 697, 10.3945/ajcn.2010.29812 Lowe, 2007, Hedonic hunger: A new dimension of appetite?, Physiol Behav, 91, 432, 10.1016/j.physbeh.2007.04.006 Lowe, 2005, Eating motives and the controversy over dieting: Eating less than needed versus less than wanted, Obesity, 13, 797, 10.1038/oby.2005.90 Appelhans, 2009, Neurobehavioral inhibition of reward-driven feeding: Implications for dieting and obesity, Obesity, 17, 640, 10.1038/oby.2008.638 Rosenstein, 1988, Differential facial responses to four basic tastes in newborns, Child Dev, 1555, 10.2307/1130670 Drewnowski, 1992, Food preferences in human obesity: Carbohydrates versus fats, Appetite, 18, 207, 10.1016/0195-6663(92)90198-F Popkin, 2001, The nutrition transition and obesity in the developing world, J Nutr, 131, 871S, 10.1093/jn/131.3.871S Crow, 2012, Obesity: Insensitive issue, Nature, 486, S12, 10.1038/486S12a Stewart, 2011, Oral sensitivity to oleic acid is associated with fat intake and body mass index, Clin Nutr, 30, 838, 10.1016/j.clnu.2011.06.007 Donaldson, 2009, Taste and weight: Is there a link?, Am J Clin Nutr, 90, 800S, 10.3945/ajcn.2009.27462Q van Baak, 2009, Consumption of sugars and body weight, Obes Rev, 10, 9, 10.1111/j.1467-789X.2008.00561.x Simchen, 2006, Odour and taste sensitivity is associated with body weight and extent of misreporting of body weight, Eur J Clin Nutr, 60, 698, 10.1038/sj.ejcn.1602371 Jansen, 2008, Negative affect and cue-induced overeating in non-eating disordered obesity, Appetite, 51, 556, 10.1016/j.appet.2008.04.009 Mustonen, 2007, Hedonic responses as predictors of food choice: Flexibility and self-prediction, Appetite, 49, 159, 10.1016/j.appet.2007.01.005 Yeomans, 2004, Palatability: Response to nutritional need or need-free stimulation of appetite?, Br J Nutr, 92, 3, 10.1079/BJN20041134 Egecioglu, 2011, Hedonic and incentive signals for body weight control, Rev Endocr Metab Disord, 12, 141, 10.1007/s11154-011-9166-4 Kruseman, 2010, Dietary, weight, and psychological changes among patients with obesity, 8 years after gastric bypass, J Am Diet Assoc, 110, 527, 10.1016/j.jada.2009.12.028 Bavaresco, 2010, Nutritional course of patients submitted to bariatric surgery, Obes Surg, 20, 716, 10.1007/s11695-008-9721-6 Ernst, 2009, Differential changes in dietary habits after gastric bypass versus gastric banding operations, Obes Surg, 19, 274, 10.1007/s11695-008-9769-3 Bueter, 2011, Alterations of sucrose preference after Roux-en-Y gastric bypass, Physiol Behav, 10.1016/j.physbeh.2011.07.025 Miras, 2012, Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task, Am J Clin Nutr, 10.3945/ajcn.112.036921 de Araujo, 2008, Food reward in the absence of taste receptor signaling, Neuron, 57, 930, 10.1016/j.neuron.2008.01.032 Adam, 2007, Stress, eating and the reward system, Physiol Behav, 91, 449, 10.1016/j.physbeh.2007.04.011 Kelley, 2002, The neuroscience of natural rewards: Relevance to addictive drugs, J Neurosci., 22, 3306, 10.1523/JNEUROSCI.22-09-03306.2002 Schultz, 1997, A neural substrate of prediction and reward, Science, 275, 1593, 10.1126/science.275.5306.1593 Schultz, 2002, Getting formal with dopamine and reward, Neuron, 36, 241, 10.1016/S0896-6273(02)00967-4 Stefani, 2006, Rule learning and reward contingency are associated with dissociable patterns of dopamine activation in the rat prefrontal cortex, nucleus accumbens, and dorsal striatum, J Neurosci, 26, 8810, 10.1523/JNEUROSCI.1656-06.2006 Wise, 2002, Brain reward circuitry: Insights from unsensed incentives, Neuron, 36, 229, 10.1016/S0896-6273(02)00965-0 Haber, 2009, The reward circuit: Linking primate anatomy and human imaging, Neuropsychopharmacology, 35, 4, 10.1038/npp.2009.129 Berridge, 2009, ‘Liking’and ‘wanting’ food rewards: Brain substrates and roles in eating disorders, Physiol Behav, 97, 537, 10.1016/j.physbeh.2009.02.044 Mela, 2006, Eating for pleasure or just wanting to eat? Reconsidering sensory hedonic responses as a driver of obesity, Appetite, 47, 10, 10.1016/j.appet.2006.02.006 Finlayson, 2007, Is it possible to dissociate ‘liking’and ‘wanting’ for foods in humans?. A novel experimental procedure, Physiol Behav, 90, 36, 10.1016/j.physbeh.2006.08.020 Berridge, 1996, Food reward: Brain substrates of wanting and liking, Neurosci Biobehav Rev, 20, 1, 10.1016/0149-7634(95)00033-B Lemmens, 2011, Stress augments food ‘wanting’ and energy intake in visceral overweight subjects in the absence of hunger, Physiol Behav, 10.1016/j.physbeh.2011.01.009 Bellisle, 2012, Sweetness, satiation, and Satiety, J Nutr, 142, 1149S, 10.3945/jn.111.149583 Born, 2010, Brain representation of liking and wanting as a function of hunger and satiety, Appetite, 54, 635, 10.1016/j.appet.2010.04.027 Barbano, 2007, Opioids for hedonic experience and dopamine to get ready for it, Psychopharmacology, 191, 497, 10.1007/s00213-006-0521-1 Havermans, 2011, You say it's liking, say it's wanting on the difficulty of disentangling food reward in man, Appetite, 57, 286, 10.1016/j.appet.2011.05.310 Small, 2003, Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers, Neuroimage, 19, 1709, 10.1016/S1053-8119(03)00253-2 Wang, 2001, Brain dopamine and obesity, Lancet, 357, 354, 10.1016/S0140-6736(00)03643-6 Volkow, 2008, Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors, Neuroimage, 42, 1537, 10.1016/j.neuroimage.2008.06.002 Stice, 2008, Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele, Science, 322, 449, 10.1126/science.1161550 Rothemund, 2007, Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals, Neuroimage, 37, 410, 10.1016/j.neuroimage.2007.05.008 Stoeckel, 2008, Widespread reward-system activation in obese women in response to pictures of high-calorie foods, Neuroimage, 41, 636, 10.1016/j.neuroimage.2008.02.031 Stice, 2010, Reward circuitry responsivity to food predicts future increases in body mass: Moderating effects of DRD2 and DRD4, Neuroimage, 50, 1618, 10.1016/j.neuroimage.2010.01.081 Kelley, 2003, Restricted daily consumption of a highly palatable food (chocolate Ensure®) alters striatal enkephalin gene expression, Eur J Neurosci, 18, 2592, 10.1046/j.1460-9568.2003.02991.x Stice, 2010, Weight gain is associated with reduced striatal response to palatable food, J Neurosci, 30, 13105, 10.1523/JNEUROSCI.2105-10.2010 Leddy, 2004, Influence of methylphenidate on eating in obese men, Obesity, 12, 224, 10.1038/oby.2004.29 Goldfield, 2007, Methylphenidate reduces energy intake and dietary fat intake in adults: A mechanism of reduced reinforcing value of food?, Am J Clin Nutr, 86, 308, 10.1093/ajcn/86.2.308 Dunn, 2010, Decreased dopamine type 2 receptor availability after bariatric surgery: Preliminary findings, Brain Res, 1350, 123, 10.1016/j.brainres.2010.03.064 Steele, 2010, Alterations of central dopamine receptors before and after gastric bypass surgery, Obes Surg, 20, 369, 10.1007/s11695-009-0015-4 Bodnar, 2004, Endogenous opioids and feeding behavior: A 30-year historical perspective, Peptides, 25, 697, 10.1016/j.peptides.2004.01.006 Gosnell, 1996, Stimulation of ingestive behavior by preferential and selective opioid agonists, Drug receptor subtypes and ingestive behaviour, 147 Gosnell, 2009, Reward systems and food intake: Role of opioids, Int J Obes (Lond), 33, S54, 10.1038/ijo.2009.73 le Merrer, 2009, Reward processing by the opioid system in the brain, Physiol Rev, 89, 1379, 10.1152/physrev.00005.2009 Berthoud, 2007, Interactions between the “cognitive” and “metabolic” brain in the control of food intake, Physiol Behav, 91, 486, 10.1016/j.physbeh.2006.12.016 Pandit, 2011, Neurobiology of overeating and obesity: The role of melanocortins and beyond, Eur J Pharmacol, 10.1016/j.ejphar.2011.01.034 Zhang, 2002, Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens, Psychopharmacology, 10.1007/s00213-001-0932-y Kelley, 2002, Opioid modulation of taste hedonics within the ventral striatum, Eur J Pharmacol, 76, 365 Peciña, 2005, Hedonic hot spot in nucleus accumbens shell: Where do (-opioids cause increased hedonic impact of sweetness?, J Neurosci, 25, 11777, 10.1523/JNEUROSCI.2329-05.2005 Peciña, 2000, Opioid site in nucleus accumbens shell mediates eating and hedonic ‘liking’ for food: Map based on microinjection Fos plumes, Brain Res, 863, 71, 10.1016/S0006-8993(00)02102-8 Yeomans, 2002, Opioid peptides and the control of human ingestive behaviour, Neurosci Biobehav Rev, 26, 713, 10.1016/S0149-7634(02)00041-6 Thompson, 1982, Opiate receptor blockade in man reduces 2-deoxy-D-glucose-induced food intake but not hunger, thirst, and hypothermia, Life Sci, 31, 847, 10.1016/0024-3205(82)90539-2 Trenchard, 1983, Naloxone reduces the food intake of normal human volunteers, Appetite, 4, 43, 10.1016/S0195-6663(83)80045-2 Drewnowski, 1992, Taste responses and preferences for sweet high-fat foods: Evidence for opioid involvement, Physiol Behav, 51, 371, 10.1016/0031-9384(92)90155-U Fantino, 1986, An opioid antagonist, naltrexone, reduces preference for sucrose in humans, Am J Physiol, 251, R91 Bertino, 1991, Naltrexone, an opioid blocker, alters taste perception and nutrient intake in humans, Am J Physiol, 261, R59 Oncken, 2001, Adverse effects of oral naltrexone: Analysis of data from two clinical trials, Psychopharmacology, 154, 397, 10.1007/s002130000666 Nathan, 2012, Opioid receptor modulation of hedonic taste preference and food intake: A single-dose safety, pharmacokinetic, and pharmacodynamic investigation with GSK1521498, a novel (-opioid receptor inverse agonist, J Clin Pharmacol, 52, 464, 10.1177/0091270011399577 Rabiner, 2011, Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans, Mol Psychiatry, 16, 826, 10.1038/mp.2011.29 Haghighi, 2013, Opioid receptor mu 1 gene, fat intake and obesity in adolescence, Mol Psychiatry Campfield, 1995, Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks, Science, 269, 546, 10.1126/science.7624778 Collins, 1996, Role of leptin in fat regulation, Nature, 380, 677, 10.1038/380677a0 Friedman, 1998, Leptin and the regulation of body weight in mammals, Nature, 395, 763, 10.1038/27376 Davis, 2010, Insulin, leptin and reward, Trends Endocrinol Metab, 21, 68, 10.1016/j.tem.2009.08.004 Fulton, 2000, Modulation of brain reward circuitry by leptin, Science, 287, 125, 10.1126/science.287.5450.125 Figlewicz, 2003, Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat, Brain Res, 964, 107, 10.1016/S0006-8993(02)04087-8 Williams, 2005, Regulation of ghrelin in physiologic and pathophysiologic states, J Nutr, 135, 1320, 10.1093/jn/135.5.1320 Farooqi, 2007, Leptin regulates striatal regions and human eating behavior, Science, 317, 1355, 10.1126/science.1144599 Jo, 2005, Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit, Neuron, 48, 1055, 10.1016/j.neuron.2005.10.021 Keisuke, 2011, The gut hormones in appetite regulation, J Obes, 2011 Truett, 2005, Ghrelin: Its role in energy balance, J Nutr, 135, 1313, 10.1093/jn/135.5.1313 Theander-Carrillo, 2006, Ghrelin action in the brain controls adipocyte metabolism, J Clin Invest, 116, 1983, 10.1172/JCI25811 Nakazato, 2001, A role for ghrelin in the central regulation of feeding, Nature, 409, 194, 10.1038/35051587 Tschöp, 2000, Ghrelin induces adiposity in rodents, Nature, 407, 908, 10.1038/35038090 Chen, 2004, Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein, Endocrinology, 145, 2607, 10.1210/en.2003-1596 Wang, 2002, Peripheral ghrelin selectively increases Fos expression in neuropeptide Y–synthesizing neurons in mouse hypothalamic arcuate nucleus, Neurosci Lett, 325, 47, 10.1016/S0304-3940(02)00241-0 Goto, 2006, Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures, Endocrinology, 147, 5102, 10.1210/en.2006-0104 Naleid, 2005, Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens, Peptides, 26, 2274, 10.1016/j.peptides.2005.04.025 Malik, 2008, Ghrelin modulates brain activity in areas that control appetitive behavior, Cell Metab, 7, 400, 10.1016/j.cmet.2008.03.007 Tatemoto, 1982, Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptiden, Nature, 10.1038/296659a0 Batterham, 2007, PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans, Nature, 450, 106, 10.1038/nature06212 Batterham, 2002, Gut hormone PYY3-36 physiologically inhibits food intake, Nature, 418, 650, 10.1038/nature00887 Batterham, 2003, Inhibition of food intake in obese subjects by peptide YY3-36, N Engl J Med, 349, 941, 10.1056/NEJMoa030204 Turton, 1996, A role for glucagon-like peptide-1 in the central regulation of feeding, Nature, 379, 69, 10.1038/379069a0 Holst, 2007, The physiology of glucagon-like peptide 1, Physiological reviews, 87, 1409, 10.1152/physrev.00034.2006 Thorens, 1993, Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor, Diabetes, 42, 1678, 10.2337/diab.42.11.1678 Laferrere, 2011, Diabetes remission after bariatric surgery: Is it just the incretins?, Int J Obes (Lond), 35, S22, 10.1038/ijo.2011.143 Liu, 2011, Roux-en-Y gastric bypass-induced improvement of glucose tolerance and insulin resistance in type 2 diabetic rats are mediated by glucagon-like peptide-1, Obes Surg, 1 Dickson, 2012, The glucagon-like peptide 1 (glp-1) analogue, exendin-4. Decreases the rewarding value of food: A new role for mesolimbic glp-1 receptors, J Neurosci, 32, 4812, 10.1523/JNEUROSCI.6326-11.2012 Dossat, 2011, Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake, J Neurosci, 31, 14453, 10.1523/JNEUROSCI.3262-11.2011