Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

Baker, 1989, Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas, Science, 244, 217, 10.1126/science.2649981 Baker, 1990, Suppression of human colorectal carcinoma cell growth by wild-type p53, Science, 249, 912, 10.1126/science.2144057 Balmain, 1988, Oncogene activation in chemical carcinogenesis, Adv. Cancer Res., 51, 147, 10.1016/S0065-230X(08)60222-5 Balmain, 1984, Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas, Nature, 307, 658, 10.1038/307658a0 Balmain, 1992, Functional loss of tumor suppressor genes in multistage chemical carcinogenesis, 97 Barbacid, 1987, ras genes, Annu. Rev. Biochem., 56, 779, 10.1146/annurev.bi.56.070187.004023 Bar-Sagi, 1985, Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation, Cell, 42, 841, 10.1016/0092-8674(85)90280-6 Bennett, 1992, p53 mutation and protein accumulation during multistage human esophageal carcinogenesis, Cancer Res, 52, 6092 Bischoff, 1991, Tumorigenic transformation of spontaneously immortalized fibroblasts from patients with a familial cancer syndrome, Oncogene, 6, 183 Bizub, 1986, Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons, 83, 6048 Bremner, 1990, Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7, Cell, 61, 407, 10.1016/0092-8674(90)90523-H Brown, 1990, Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression, 87, 538 Burns, 1991, Loss of heterozygosity and mutational alterations of the p53 gene in skin tumors of interspecific hybrid mice, Oncogene, 6, 2363 Diller, 1990, p53 functions as a cell cycle control protein in osteosarcomas, Mol. Cell. Biol., 10, 5772, 10.1128/MCB.10.11.5772 Donehower, 1992, Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours, Nature, 356, 215, 10.1038/356215a0 Eliyahu, 1989, Wild-type p53 can inhibit oncogene-mediated focus formation, 86, 8763 Ellis, 1980, Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus, J. Virol., 36, 408, 10.1128/JVI.36.2.408-420.1980 Fearon, 1990, A genetic model for colorectal tumorigenesis, Cell, 61, 759, 10.1016/0092-8674(90)90186-I Feinstein, 1992, Expression of the normal p53 gene induces differentiation of K562 cells, Oncogene, 7, 1853 Finlay, 1989, The p53 proto-oncogene can act as a suppressor of transformation, Cell, 57, 1083, 10.1016/0092-8674(89)90045-7 Fults, 1992, p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression, Cancer Res., 52, 674 Furstenberger, 1989, Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: correlation between chromosomal damage and conversion (“stage I of tumor promotion”) in vivo, Carcinogenesis, 10, 749, 10.1093/carcin/10.4.749 Groden, 1991, Identification and characterization of the familial adenomatous polyposis coli gene, Cell, 66, 589, 10.1016/0092-8674(81)90021-0 Guerrero, 1987, Mutational activation of oncogenes in animal model systems of carcinogenesis, Mutat. Res., 185, 293, 10.1016/0165-1110(87)90021-2 Gusterson, 1991, Expression of p53 in premalignant and malignant squamous epithelium, Oncogene, 6, 1785 Harvey, 1993, In vitro groth characteristics of embryo fibroblasts isolated from p53-deficient mice, Oncogene 1982 Hennings, 1985, Induction of papillomas with a high probability of conversion to malignancy, Carcinogenesis, 6, 1607, 10.1093/carcin/6.11.1607 Jenkins, 1982, Organization, distribution and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus, J. Virol., 43, 26, 10.1128/JVI.43.1.26-36.1982 Kastan, 1992, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia, Cell, 71, 587, 10.1016/0092-8674(92)90593-2 Kinzler, 1991, Identification of FAP locus genes from chromosome 5q21, Science, 253, 661, 10.1126/science.1651562 Klein-Szanto, 1989, Pathology of human and experimental skin tumors, 19 Klinedinst, 1991, Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells, Mutat. Res., 250, 365, 10.1016/0027-5107(91)90193-R Laird, 1991, Simplified mammalian DNA isolation procedure, Nucl. Acids Res., 19, 4293, 10.1093/nar/19.15.4293 Lane, 1992, p53, guardian of the genome, Nature, 358, 15, 10.1038/358015a0 Lane, 1990, p53: oncogene or anti-oncogene, Genes Dev., 4, 1, 10.1101/gad.4.1.1 Lasko, 1991, Loss of constitutional heterozygosity in human cancer, Annu. Rev. Genet., 25, 281, 10.1146/annurev.ge.25.120191.001433 Li, 1988, A cancer family syndrome in twenty-four kindreds, Cancer Res., 48, 5358 Livingstone, 1992, Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53, Cell, 70, 923, 10.1016/0092-8674(92)90243-6 Loeb, 1991, Mutator phenotype may be required for multistage carcinogenesis, Cancer Res., 51, 3075 Malkin, 1990, Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms, Science, 250, 1233, 10.1126/science.1978757 Marshall, 1991, Tumor suppressor genes, Cell, 64, 313, 10.1016/0092-8674(91)90641-B Mercer, 1990, Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53, 87, 6166 Michalovitz, 1990, Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53, Cell, 62, 671, 10.1016/0092-8674(90)90113-S Nowell, 1989, The clonal nature of neoplasia, Cancer Cells, 1, 29 Parada, 1984, Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation, Nature, 312, 649, 10.1038/312649a0 Powell, 1992, APC mutations occur early during colorectal tumorigenesis, Nature, 359, 235, 10.1038/359235a0 Quintanilla, 1986, Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis, Nature, 322, 78, 10.1038/322078a0 Ruggeri, 1991, Alterations of the p53 tumor suppressor gene during mouse skin tumor progression, Cancer Res., 51, 6615 Shaulsky, 1991, Involvement of wild-type p53 in pre-B-cell differentiation in vitro, 88, 8982 Shaw, 1992, Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line, 89, 4495 Sidransky, 1992, Clonal expansion of p53 mutant cells is associated with brain tumour progression, Nature, 355, 846, 10.1038/355846a0 Srivastava, 1990, Germ line transmission of a mutated p53 gene in a family with Li-Fraumeni syndrome, Nature, 348, 747, 10.1038/348747a0 Stenman, 1987, Transfection with plasmid pSV2ptEJ induces chromosome rearrangements in CHEF cells, 84, 184 Sukumar, 1990, An experimental approach to cancer, Cancer Cells, 2, 199 Temin, 1988, Evolution of cancer genes as a mutation-driven process, Cancer Res., 48, 1697 Vogelstein, 1990, Cancer: a deadly inheritance, Nature, 348, 681, 10.1038/348681a0 von Deimling, 1992, p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma, Cancer Res., 52, 2987 Weinberg, 1989, Oncogenes, antioncogenes, and the molecular basis of multistep carcinogenesis, Cancer Res., 49, 3713 Yandell, 1986, Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele-loss than by intragenic structural alterations, Som. Cell. Mol. Genet., 12, 255, 10.1007/BF01570784 Yin, 1992, Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles, Cell, 70, 937, 10.1016/0092-8674(92)90244-7 Yonish-Rouach, 1991, Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6, Nature, 352, 345, 10.1038/352345a0 Yonish-Rouach, 1993, p53-mediated cell death: relationship to cell cycle control, Mol. Cell. Biol., 13, 1415, 10.1128/MCB.13.3.1415 Yuspa, 1983, Altered growth and differentiation of cultured mouse epidermal cells infected with oncogenic retrovirus: contrasting effects of viruses and chemicals, Cancer Res., 43, 6021