Neuroinflammation in Hepatic Encephalopathy: Mechanistic Aspects

Lockwood, 1991, Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy, J Cereb Blood Flow Metab, 11, 337, 10.1038/jcbfm.1991.67 Norenberg, 1981, The astrocyte in liver disease, Vol. 2, 303 Martin, 1987, Morphometric and densitometric investigations of protoplasmic astrocytes and neurons in human hepatic encephalopathy, Exp Pathol, 32, 241, 10.1016/S0232-1513(87)80035-X Lee, 2012, Acute liver failure, Semin Respir Crit Care Med, 33, 36, 10.1055/s-0032-1301733 Jalan, 2004, Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow, J Hepatol, 41, 613, 10.1016/j.jhep.2004.06.011 Larsen, 2000, Intensive care management of patients with acute liver failure with emphasis on systemic hemodynamic instability and cerebral edema: a critical appraisal of pathophysiology, Can J Gastroenterol, 14, 105D, 10.1155/2000/493629 Shawcross, 2012, The neurological manifestations of acute liver failure, Neurochem Int, 60, 662, 10.1016/j.neuint.2011.10.006 Norenberg, 1977, A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder, Lab Invest, 36, 618 Voorhies, 1983, Acute hyperammonemia in the young primate. Physiologic and neuropathological correlates, Pediatr Res, 17, 970, 10.1203/00006450-198312000-00009 Traber, 1987, Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood–brain barrier, Hepatology, 7, 1272, 10.1002/hep.1840070616 Swain, 1991, Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats, Am J Physiol Regul Integr Comp Physiol, 261, R1491, 10.1152/ajpregu.1991.261.6.R1491 Kato, 1992, Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure, Hepatology, 15, 1060, 10.1002/hep.1840150615 Norenberg, 1987, The role of astrocytes in hepatic encephalopathy, Neurochem Pathol, 6, 13, 10.1007/BF02833599 Martinez-Hernandez, 1977, Glutamine synthetase: glial localization in brain, Science, 195, 1356, 10.1126/science.14400 Norenberg, 1992, Hepatic encephalopathy: a disorder in glial-neuronal communication, Prog Brain Res, 94, 261, 10.1016/S0079-6123(08)61756-2 Conn, 1978 Gregorios, 1985, Morphologic effects of ammonia on primary astrocyte cultures. I: light microscopic studies, J Neuropathol Exp Neurol, 44, 397, 10.1097/00005072-198507000-00003 Gregorios, 1985, Morphologic effects of ammonia on primary astrocyte cultures. II: electron microscopic studies, J Neuropathol Exp Neurol, 44, 404, 10.1097/00005072-198507000-00004 Blei, 1994, Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis, Hepatology, 19, 1437, 10.1002/hep.1840190619 Clemmesen, 1999, Cerebral herniation in acute liver failure is correlated with arterial ammonia concentration, Hepatology, 29, 648, 10.1002/hep.510290309 Coltart, 2013, Inflammation and hepatic encephalopathy, Arch Biochem Biophys, 536, 189, 10.1016/j.abb.2013.03.016 Odeh, 2007, Pathogenesis of hepatic encephalopathy: the tumour necrosis factor-alpha theory, Eur J Clin Invest, 37, 291, 10.1111/j.1365-2362.2007.01778.x Norenberg, 2009, Signaling factors in the mechanism of ammonia neurotoxicity, Metab Brain Dis, 24, 103, 10.1007/s11011-008-9113-6 Norenberg, 2007, New concepts in the mechanism of ammonia-induced astrocyte swelling, Metab Brain Dis, 22, 219, 10.1007/s11011-007-9062-5 Rama Rao, 2014, Brain edema in acute liver failure: mechanisms and concepts, Metab Brain Dis, 10.1007/s11011-014-9502-y Bodega, 2007, Effect of ammonia on ciliary neurotrophic factor mRNA and protein expression and its upstream signalling pathway in cultured rat astroglial cells: possible implication of c-fos, Sp1 and p38MAPK, Neuropathol Appl Neurobiol, 33, 420, 10.1111/j.1365-2990.2007.00831.x Konopacka, 2009, Protein kinase G is involved in ammonia-induced swelling of astrocytes, J Neurochem, 109, 246, 10.1111/j.1471-4159.2009.05802.x Aspinall, 2011, A Src family kinase inhibitor improves survival in experimental acute liver failure associated with elevated cerebral and circulating vascular endothelial growth factor levels, Liver Int, 31, 1222, 10.1111/j.1478-3231.2011.02554.x Panickar, 2009, Ammonia-induced activation of p53 in cultured astrocytes: role in cell swelling and glutamate uptake, Neurochem Int, 55, 98, 10.1016/j.neuint.2008.12.022 Schliess, 2002, Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes, FASEB J, 16, 739, 10.1096/fj.01-0862fje Sinke, 2008, NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture, J Neurochem, 106, 2302 Jayakumar, 2011, NF-κB in the mechanism of brain edema in acute liver failure: studies in transgenic mice, Neurobiol Dis, 41, 498, 10.1016/j.nbd.2010.10.021 Jayakumar, 2008, Na-K-Cl Cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling, J Biol Chem, 283, 33874, 10.1074/jbc.M804016200 Jayakumar, 2011, The Na-K-Cl cotransporter in the brain edema of acute liver failure, J Hepatol, 54, 272, 10.1016/j.jhep.2010.06.041 Jayakumar, 2014, Sulfonylurea receptor 1 contributes to the astrocyte swelling and brain edema in acute liver failure, Transl Stroke Res, 5, 28, 10.1007/s12975-014-0328-z Rama Rao, 2010, Brain aquaporin-4 in experimental acute liver failure, J Neuropathol Exp Neurol, 69, 869, 10.1097/NEN.0b013e3181ebe581 Gans, 1971, Septicemia as a manifestation of acute liver failure, Surg Gynecol Obstet, 132, 783 Wilkinson, 1974, Relation of renal impairment and haemorrhagic diathesis to endotoxaemia in fulminant hepatic failure, Lancet, 1, 521, 10.1016/S0140-6736(74)92711-1 Liehr, 1976, Endotoxaemia in acute hepatic failure, Acta Hepatogastroenterol (Stuttg), 23, 235 Wyke, 1982, Bacteraemia in patients with fulminant hepatic failure, Liver, 2, 45, 10.1111/j.1600-0676.1982.tb00177.x Izumi, 1995, Acute phase response after liver transplantation for fulminant hepatic failure and cirrhosis, Transpl Int, 8, 340, 10.1111/j.1432-2277.1995.tb01533.x Wigmore, 1998, Pro-inflammatory cytokine release and mediation of the acute phase protein response in fulminant hepatic failure, Intensive Care Med, 24, 224, 10.1007/s001340050554 Wright, 2007, Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension, Metab Brain Dis, 22, 375, 10.1007/s11011-007-9071-4 Banks, 1995, Passage of cytokines across the blood-brain barrier, Neuroimmunomodulation, 2, 241, 10.1159/000097202 Chung, 2001, Indomethacin prevents the development of experimental ammonia-induced brain edema in rats after portacaval anastomosis, Hepatology, 34, 249, 10.1053/jhep.2001.26383 Clemmesen, 1997, Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin, Hepatology, 26, 1423, 10.1002/hep.510260608 Jiang, 2009, Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia, J Cereb Blood Flow Metab, 29, 944, 10.1038/jcbfm.2009.18 Böcker, 1991, Evaluation of the hepatotoxic potential of minocycline, Antimicrob Agents Chemother, 35, 1434, 10.1128/AAC.35.7.1434 Malcolm, 1996, Minocycline-induced liver injury, Am J Gastroenterol, 91, 1641 Bemeur, 2010, IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure, Neurochem Int, 56, 213, 10.1016/j.neuint.2009.11.010 Chastre, 2012, Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications, PLoS One, 7, e49670, 10.1371/journal.pone.0049670 Butterworth, 2013, The liver-brain axis in liver failure: neuroinflammation and encephalopathy, Nat Rev Gastroenterol Hepatol, 10, 522, 10.1038/nrgastro.2013.99 Rama Rao, 2010, Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes, J Neuroinflammation, 7, 66, 10.1186/1742-2094-7-66 Frank-Cannon, 2009, Does neuroinflammation fan the flame in neurodegenerative diseases?, Mol Neurodegener, 4, 47, 10.1186/1750-1326-4-47 Chastre, 2010, Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure, Metab Brain Dis, 25, 17, 10.1007/s11011-010-9185-y Rodrigo, 2010, Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy, Gastroenterology, 139, 675, 10.1053/j.gastro.2010.03.040 Garden, 2006, Microglia biology in health and disease, J Neuroimmune Pharmacol, 1, 127, 10.1007/s11481-006-9015-5 Görg, 2013, Gene expression profiling in the cerebral cortex of patients with cirrhosis with and without hepatic encephalopathy, Hepatology, 57, 2436, 10.1002/hep.26265 Butterworth, 2011, Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets, Neurochem Int, 59, 830, 10.1016/j.neuint.2011.07.014 Rao, 2013, Microglia contribute to ammonia-induced astrocyte swelling in culture, Metab Brain Dis, 28, 139, 10.1007/s11011-012-9339-1 Khanna, 2014, Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema, Transl Stroke Res, 5, 3, 10.1007/s12975-013-0307-9 Rangroo Thrane, 2012, Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy, Neuroscience, 220, 247, 10.1016/j.neuroscience.2012.06.022 Nguyen, 2006, Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice, J Hepatol, 44, 1105, 10.1016/j.jhep.2005.09.019 Jayakumar, 2013, Brain edema in acute liver failure: role of neurosteroids, Arch Biochem Biophys, 536, 171, 10.1016/j.abb.2013.03.007 Hermenegildo, 1996, NMDA receptor antagonists prevent acute ammonia toxicity in mice, Neurochem Res, 21, 1237, 10.1007/BF02532401 Paul, 1999, Independent and combined effects of L-arginine and diazepam on ammonium chloride-induced convulsions in rats, Indian J Physiol Pharmacol, 43, 199 Vanaja, 2001, Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam, Neurol Res, 23, 622, 10.1179/016164101101198901 Chen, 2014, Morphological changes of cortical pyramidal neurons in hepatic encephalopathy, BMC Neurosci, 15, 15, 10.1186/1471-2202-15-15 D'Mello, 2009, Cerebral microglia recruits monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation, J Neurosci, 29, 2089, 10.1523/JNEUROSCI.3567-08.2009 Agusti, 2011, p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts, Gut, 60, 1572, 10.1136/gut.2010.236083 Zemtsova, 2011, Microglia activation in hepatic encephalopathy in rats and humans, Hepatology, 54, 204, 10.1002/hep.24326 Wright, 2014, Characterisation of temporal microglia and astrocyte immune responses in bile duct-ligated rat models of cirrhosis, Liver Int, 10.1111/liv.12481 Brück, 2011, Locomotor impairment and cerebrocortical oxidative stress in portal vein ligated rats in vivo, J Hepatol, 54, 251, 10.1016/j.jhep.2010.06.035 Jayakumar, 2006, Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes, J Neurosci, 26, 4774, 10.1523/JNEUROSCI.0120-06.2006 Jayakumar, 2009, Calcium in the mechanism of ammonia-induced astrocyte swelling, J Neurochem, 109, 252, 10.1111/j.1471-4159.2009.05842.x Feuerstein, 1998, The role of cytokines in the neuropathology of stroke and neurotrauma, Neuroimmunomodulation, 5, 143, 10.1159/000026331 Jayakumar, 2012, Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy, Neuroscience, 218, 305, 10.1016/j.neuroscience.2012.05.006 Jayakumar, 2013, Endothelial-astrocytic interactions in acute liver failure, Metab Brain Dis, 28, 183, 10.1007/s11011-012-9344-4 Jayakumar, 2014, Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy, J Neurochem, 128, 890, 10.1111/jnc.12516 Skowrońska, 2012, Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases, J Neurochem, 121, 125, 10.1111/j.1471-4159.2012.07669.x Hashimoto, 1991, Action site of circulating interleukin-1 on the rabbit brain, Brain Res, 540, 217, 10.1016/0006-8993(91)90510-3 Matsumura, 2004, Signaling the brain in inflammation: the role of endothelial cells, Front Biosci, 9, 2819, 10.2741/1439