Cannabinoid receptor 1 is a major mediator of renal fibrosis

Kidney International - Tập 88 Số 1 - Trang 72-84 - 2015
Lola Lecru1, Christophe Desterke2, Stanislas Grassin‐Delyle3, Christos Chatziantoniou4, Sophie Vandermeersch4, Aurore Devocelle1, Amélia Vernochet1, N Ivanovski1, Catherine Ledent5, Sophie Ferlicot6, Meriem Dalia1, Myriam Saïd1, Séverine Beaudreuil6,1, Bernard Charpentier6,1, Aimé Vázquez1, Julien Giron‐Michel1, Bruno Azzarone7, Antoine Dürrbach6,1,8, Arnaud François6,1,8
1INSERM Unité 1014, Régulation de la survie et des Allogreffes, Institut André Lwoff, Hôpital Paul Brousse, Villejuif, France
2INSERM Unité 972, Transfert des gènes dans le foie: Applications Thérapeutiques, Institut André Lwoff, Hôpital Paul Brousse, Villejuif, France
3Université de Versailles Saint-Quentin, Mass Spectrometry Facility, MasSpecLab, Versailles, France
4UMRS 702, Remodelage et Réparation du Tissu Rénal, Hôpital Tenon, Paris, France
5Institut de la Recherche Interdisciplinaire en Biologie Humaine Et Moléculaire, Bruxelles, Belgium
6AP-HP Hôpital Bicêtre, Le Kremlin-Bicêtre, France
7Immunology Department, Istituto Giannina Gaslini, Genova, Italy
8Institut Francilien de Recherche en Néphrologie et Transplantation, le Kremlin-Bicêtre, France

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Tài liệu tham khảo

Bascands, 2005, Obstructive nephropathy: insights from genetically engineered animals, Kidney Int, 68, 925, 10.1111/j.1523-1755.2005.00486.x

Dol-Gleizes, 2008, Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice, Arterioscler Thromb Vasc Biol, 29, 12, 10.1161/ATVBAHA.108.168757

Janiak, 2007, Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats, Kidney Int, 72, 1345, 10.1038/sj.ki.5002540

Deutsch, 1997, Production and physiological actions of anandamide in the vasculature of the rat kidney, J Clin Invest, 100, 1538, 10.1172/JCI119677

Barutta, 2010, Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy, Diabetes, 59, 1046, 10.2337/db09-1336

Julien, 2005, Antifibrogenic role of the cannabinoid receptor CB2 in the liver, Gastroenterology, 128, 742, 10.1053/j.gastro.2004.12.050

Boor, 2012, The renal (myo-)fibroblast: a heterogeneous group of cells, Nephrol Dial Transplant, 27, 3027, 10.1093/ndt/gfs296

Mesnard, 2009, Invariant natural killer T cells and TGF-beta attenuate anti-GBM glomerulonephritis, J Am Soc Nephrol, 20, 1282, 10.1681/ASN.2008040433

Bascands, 2005, Obstructive nephropathy: insights from genetically engineered animals, Kidney Int, 68, 925, 10.1111/j.1523-1755.2005.00486.x

Han, 2009, CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages, Cardiovasc Res, 84, 378, 10.1093/cvr/cvp240

Brosius, 2009, Mouse models of diabetic nephropathy, J Am Soc Nephrol, 20, 2503, 10.1681/ASN.2009070721

Le, 2004, Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency, Hypertension, 43, 445, 10.1161/01.HYP.0000112423.28987.00

Chorvat, 2013, Peripherally restricted CB1 receptor blockers, Bioorg Med Chem Lett, 23, 4751, 10.1016/j.bmcl.2013.06.066

Marquart, 2010, Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis, Arthritis Rheum, 62, 3467, 10.1002/art.27642

Teixeira-Clerc, 2006, CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis, Nat Med, 12, 671, 10.1038/nm1421

Slavic, 2013, Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome, J Mol Med Berl Ger, 91, 811, 10.1007/s00109-013-1034-0

André, 2010, The endocannabinoid system: its roles in energy balance and potential as a target for obesity treatment, Int J Biochem Cell Biol, 42, 1788, 10.1016/j.biocel.2010.06.002

Nam, 2012, Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice, Endocrinology, 153, 1387, 10.1210/en.2011-1423

Defer, 2009, The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy, FASEB J Off Publ Fed Am Soc Exp Biol, 23, 2120

Servettaz, 2010, Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis, Am J Pathol, 177, 187, 10.2353/ajpath.2010.090763

Barutta, 2011, Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy, Diabetes, 60, 2386, 10.2337/db10-1809

Barutta, 2014, Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice, Kidney Int [Internet], 86, 979, 10.1038/ki.2014.165

Wynn, 2007, Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases, J Clin Invest, 117, 524, 10.1172/JCI31487

Sato, 2003, Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction, J Clin Invest., 112, 1486, 10.1172/JCI200319270

Eis, 2004, Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction, J Am Soc Nephrol, 15, 337, 10.1097/01.ASN.0000111246.87175.32

Henderson, 2008, Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis, Am J Pathol, 172, 288, 10.2353/ajpath.2008.070726

Schatz, 1997, Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system, Toxicol Appl Pharmacol, 142, 278, 10.1006/taap.1996.8034

Wang, 2011, Macrophages in renal disease, J Am Soc Nephrol, 22, 21, 10.1681/ASN.2010030269

Wang, 2009, Aggravated renal inflammatory responses in TRPV1 gene knockout mice subjected to DOCA-salt hypertension, Am J Physiol Renal Physiol, 297, F1550, 10.1152/ajprenal.00012.2009

Ledent, 1999, Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice, Science, 283, 401, 10.1126/science.283.5400.401

Grimwood, 2009, Propagation and culture of renal fibroblasts, Methods Mol Biol, 466, 25, 10.1007/978-1-59745-352-3_3