ProteoChip-based screening system of novel inhibitors against the interaction of VEGF165 and β-Amyloid1–42
Tóm tắt
Vascular endothelial growth factor (VEGF) protects neuronal cells from amyloid-β(Aβ)-induced neurotoxicity in the brain of Alzheimer’s disease (AD) patient. However, the accumulation of VEGF in amyloid plaques may induce local VEGF deficiency and promote development of the disease. Here we investigated that Aβ1–42 can interact with heparin binding domain (HBD) of VEGF using ProteoChip technology. The ProteoChip-based Aβ-VEGF interaction system has been used for screening of AD inhibitor. An inhibitor of Aβ1–42-VEGF165 interaction using a ProteoChip-based screening method showed suppression of Aβ1–42-induced neurotoxicity in human neuronal cells.
Tài liệu tham khảo
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