HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Araki, 2009, mTOR regulates memory CD8 T-cell differentiation, Nature., 460, 108, 10.1038/nature08155

Ben-Shoshan, 2008, Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha, Eur. J. Immunol., 38, 2412, 10.1002/eji.200838318

Benjamini, 1995, Controlling the false discovery rate: a practical and powerful approach to multiple testing, J.R. Stat. Soc. Series B Stat Methodol., 57, 289

Bensinger, 2008, Integration of metabolism and inflammation by lipid-activated nuclear receptors, Nature., 454, 470, 10.1038/nature07202

Bensinger, 2008, LXR signaling couples sterol metabolism to proliferation in the acquired immune response, Cell., 134, 97, 10.1016/j.cell.2008.04.052

Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature., 441, 235, 10.1038/nature04753

Cham, 2008, Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells, Eur. J. Immunol., 38, 2438, 10.1002/eji.200838289

Chi, 2005, Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1, J. Immunol., 174, 2485, 10.4049/jimmunol.174.5.2485

Cobbold, 2009, Infectious tolerance via the consumption of essential amino acids and mTOR signaling, Proc. Natl. Acad. Sci. USA., 106, 12055, 10.1073/pnas.0903919106

Delgoffe, 2009, The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment, Immunity., 30, 832, 10.1016/j.immuni.2009.04.014

Düvel, 2010, Activation of a metabolic gene regulatory network downstream of mTOR complex 1, Mol. Cell., 39, 171, 10.1016/j.molcel.2010.06.022

Fox, 2005, Fuel feeds function: energy metabolism and the T-cell response, Nat. Rev. Immunol., 5, 844, 10.1038/nri1710

Haxhinasto, 2008, The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells, J. Exp. Med., 205, 565, 10.1084/jem.20071477

Huang da, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat. Protoc., 4, 44, 10.1038/nprot.2008.211

Hue, 1984, Difference in glucose sensitivity of liver glycolysis and glycogen synthesis. Relationship between lactate production and fructose 2,6-bisphosphate concentration, Biochem. J., 224, 779, 10.1042/bj2240779

Jones, 2007, Revving the engine: signal transduction fuels T cell activation, Immunity., 27, 173, 10.1016/j.immuni.2007.07.008

Kang, 2010, Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis, Immunity., 32, 414, 10.1016/j.immuni.2010.03.004

Littman, 2010, Th17 and regulatory T cells in mediating and restraining inflammation, Cell., 140, 845, 10.1016/j.cell.2010.02.021

Liu, 2009, The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR, Nat. Immunol., 10, 769, 10.1038/ni.1743

Liu, 2010, The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells, Nat. Immunol., 11, 1047, 10.1038/ni.1939

Lukashev, 2006, Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes, J. Immunol., 177, 4962, 10.4049/jimmunol.177.8.4962

McGeachy, 2009, The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo, Nat. Immunol., 10, 314, 10.1038/ni.1698

Michalek, 2011, Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets, J. Immunol., 186, 3299, 10.4049/jimmunol.1003613

Neumann, 2005, Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction, Proc. Natl. Acad. Sci. USA., 102, 17071, 10.1073/pnas.0506070102

Nizet, 2009, Interdependence of hypoxic and innate immune responses, Nat. Rev. Immunol., 9, 609, 10.1038/nri2607

Pearce, 2010, Metabolism in T cell activation and differentiation, Curr. Opin. Immunol., 22, 314, 10.1016/j.coi.2010.01.018

Pearce, 2009, Enhancing CD8 T-cell memory by modulating fatty acid metabolism, Nature., 460, 103, 10.1038/nature08097

Powell, 2010, The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism, Immunity., 33, 301, 10.1016/j.immuni.2010.09.002

Rius, 2008, NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha, Nature., 453, 807, 10.1038/nature06905

Ryan, 2000, Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth, Cancer Res., 60, 4010

Sauer, 2008, T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR, Proc. Natl. Acad. Sci. USA., 105, 7797, 10.1073/pnas.0800928105

Sundrud, 2009, Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response, Science., 324, 1334, 10.1126/science.1172638

Warburg, 1956, On the origin of cancer cells, Science., 123, 309, 10.1126/science.123.3191.309

Zheng, 2009, Anergic T cells are metabolically anergic, J. Immunol., 183, 6095, 10.4049/jimmunol.0803510

Zhou, 2008, TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function, Nature., 453, 236, 10.1038/nature06878

Zhu, 2010, Differentiation of effector CD4 T cell populations (*), Annu. Rev. Immunol., 28, 445, 10.1146/annurev-immunol-030409-101212