Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

Quinten, 2011, Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation, J. Pharm. Sci., 100, 2858, 10.1002/jps.22480 Quinten, 2011, Development and evaluation of injection-molded sustained-release tablets containing ethylcellulose and polyethylene oxide, Drug Dev. Ind. Pharm., 37, 149, 10.3109/03639045.2010.498426 AppaRao, 2010, Design and evaluation of sustained release microcapsules containing diclofenac sodium, Int. J. Pharm. Biomed. Res., 1, 90 Siepmann, 2001, Modelling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC), Adv. Drug Deliv. Rev., 48, 139, 10.1016/S0169-409X(01)00112-0 Almeida, 2011, Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion, Eur. J. Pharm. Biopharm., 77, 297, 10.1016/j.ejpb.2010.12.004 Almeida, 2012, Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide, Eur. J. Pharm. Biopharm., 82, 526, 10.1016/j.ejpb.2012.08.008 Novoa, 2005, Physical solid-state properties and dissolution of sustained-release matrices of polyvinylacetate, Eur. J. Pharm. Biopharm., 59, 343, 10.1016/j.ejpb.2004.07.012 van de Weert, 2000, Protein instability in poly (lactic-co-glycolic acid) microparticles, Pharm. Res., 17, 1159, 10.1023/A:1026498209874 Fredenberg, 2011, The mechanisms of drug release in poly (lactic-co-glycolic acid)-based drug delivery systems—a review, Int. J. Pharm., 415, 34, 10.1016/j.ijpharm.2011.05.049 Kedzierewicz, 1999, Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy, J. Control. Release, 58, 195, 10.1016/S0168-3659(98)00154-0 Dang, 2013, Development of intra-vaginal matrices from polycaprolactone for sustained release of antimicrobial agents, J. Biomater. Appl., 28, 74, 10.1177/0885328212437393 Waknis, 2011, Novel poly-DL-lactide-polycaprolactone copolymer based flexible drug delivery system for sustained release of ciprofloxacin, Drug Deliv., 18, 236, 10.3109/10717544.2010.528070 Claeys, 2012, Poly (2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding, Macromol. Rapid Commun., 33, 1701, 10.1002/marc.201200332 Chiu Li, 2002, Polyanhydride implant for antibiotic delivery—from the bench to the clinic, Adv. Drug Deliv. Rev., 54, 963, 10.1016/S0169-409X(02)00053-4 Follonier, 1994, Evaluation of hot-melt extrusion as a new technique for the production of polymer-based pellets for sustained release capsules containing high loadings of freely soluble drugs, Drug Dev. Ind. Pharm., 20, 1323, 10.3109/03639049409038373 Quinten, 2012, Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding, AAPS PharmSciTech, 13, 1197, 10.1208/s12249-012-9848-6 Reitz, 2007, Solid lipid extrusion of sustained release dosage forms, Eur. J. Pharm. Biopharm., 67, 440, 10.1016/j.ejpb.2007.03.008 Windbergs, 2009, Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures, J. Control. Release, 137, 211, 10.1016/j.jconrel.2009.04.002 Müller, 2000, Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art, Eur. J. Pharm. Biopharm., 50, 161, 10.1016/S0939-6411(00)00087-4 Quinten, 2012, Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding, AAPS PharmSciTech, 13, 1197, 10.1208/s12249-012-9848-6 Reitz, 2008, Solid lipid extrudates as sustained-release matrices: the effect of surface structure on drug release properties, Eur. J. Pharm. Sci., 35, 335, 10.1016/j.ejps.2008.08.002 N. Apichatwatana, Hot Melt Extrusion for the Production of Controlled Drug Delivery Systems, PhD Thesis, 2011. Gupta, 2008, Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1, J. Pharm. Sci., 97, 4228, 10.1002/jps.21331 Johnson, 2010, Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir, Eur. J. Pharm. Sci., 39, 203, 10.1016/j.ejps.2009.11.007 Clark, 2012, A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781, J. Pharm. Sci., 101, 576, 10.1002/jps.22781 Jansen, 1993, Bacterial adherence to hydrophilic polymer-coated polyurethane stents, Gastrointest. Endosc., 39, 670, 10.1016/S0016-5107(93)70220-5 Sommer, 2010, A preliminary study on the properties and fouling-release performance of siloxane–polyurethane coatings prepared from poly (dimethylsiloxane) (PDMS) macromers, Biofouling, 26, 961, 10.1080/08927014.2010.531272 Bucky, 1994, The capsule quality of saline-filled smooth silicone, textured silicone, and polyurethane implants in rabbits: a long-term study, Plast. Reconstr. Surg., 93, 1123, 10.1097/00006534-199405000-00002 Randall, 2010 Hollinger, 2011 Król, 2007, Synthesis methods, chemical structures and phase structures of linear polyurethanes. Properties and applications of linear polyurethanes in polyurethane elastomers, copolymers and ionomers, Prog. Mater. Sci., 52, 915, 10.1016/j.pmatsci.2006.11.001 De Juan, 2003, Chemometrics applied to unravel multicomponent processes and mixtures: revisiting latest trends in multivariate resolution, Anal. Chim. Acta, 500, 195, 10.1016/S0003-2670(03)00724-4 Blomqvist, 1988, Pharmacokinetics and pharmacodynamics of controlled-release metoprolol: a comparison with atenolol, Eur. J. Clin. Pharmacol., 33, S19, 10.1007/BF00578408 Vervaeck, 2013, Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms, Eur. J. Pharm. Biopharm., 85, 587, 10.1016/j.ejpb.2013.02.003 Meier, 1974, Pharmacokinetic criteria for the evaluation of retard formulations, Eur. J. Clin. Pharmacol., 7, 429, 10.1007/BF00560355 Steinijans, 1990, Pharmacokinetic characterization of controlled-release formulations, Eur. J. Drug Metab. Pharmacokinet., 15, 173, 10.1007/BF03190201 Possemiers, 2006, The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine, J. Nutr., 136, 1862, 10.1093/jn/136.7.1862 Possemiers, 2004, PCR-DGGE-based quantification of stability of the microbial community in a simulator of the human intestinal microbial ecosystem, FEMS Microbiol. Ecol., 49, 495, 10.1016/j.femsec.2004.05.002 Matzinos, 2002, Processing and characterization of starch/polycaprolactone products, Polym. Degrad. Stab., 77, 17, 10.1016/S0141-3910(02)00072-1 John, 2013, Influence of soft segment content and chain length on the physical properties of poly (ether ester) elastomers and fabrication of honeycomb pattern and electrospun fiber, React. Funct. Polym., 73, 1213, 10.1016/j.reactfunctpolym.2013.06.004 Quinten, 2009, Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose, Eur. J. Pharm. Sci., 37, 207, 10.1016/j.ejps.2009.02.006 Claeys, 2013, Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions, Eur. J. Pharm. Biopharm., 85, 1206, 10.1016/j.ejpb.2013.01.027 Leuenberger, 1987, Percolation theory—a novel approach to solid dosage form design, Int. J. Pharm., 38, 109, 10.1016/0378-5173(87)90105-0 Aguilar-de-Leyva, 2011, Release behaviour of clozapine matrix pellets based on percolation theory, Int. J. Pharm., 404, 133, 10.1016/j.ijpharm.2010.11.024 Macfarlane, 2003, Regulation of short-chain fatty acid production, Proc. Nutr. Soc., 62, 67, 10.1079/PNS2002207 Christenson, 2004, Poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo studies, J. Biomed. Mater. Res., Part A, 69A, 407, 10.1002/jbm.a.30002 Chandra, 1998, Biodegradable polymers, Prog. Polym. Sci., 23, 1273, 10.1016/S0079-6700(97)00039-7 Jovanovic, 2011, Polyacylurethanes as novel degradable cell carrier materials for tissue engineering, Materials, 4, 1705, 10.3390/ma4101705 Kararli, 1995, Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals, Biopharm. Drug Dispos., 16, 351, 10.1002/bdd.2510160502