Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood

Steinman, 1999, Antigen capture, processing, and presentation by dendritic cells: Recent cell biological studies, Human Immunol, 60, 562, 10.1016/S0198-8859(99)00030-0 Banchereau, 1998, Dendritic cells and the control of immunity, Nature, 392, 245, 10.1038/32588 Vecchi, 1999, Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells, J Leukoc Biol, 66, 489, 10.1002/jlb.66.3.489 Papadopoulos, 1999, Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation, Eur J Immunol, 29, 2551, 10.1002/(SICI)1521-4141(199908)29:08<2551::AID-IMMU2551>3.0.CO;2-T Tang, 1999, Chemokine up-regulation and activated T cell attraction by maturing dendritic cells, Science, 284, 819, 10.1126/science.284.5415.819 de Saint-Vis, 1998, The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation, J Immunol, 160, 1666, 10.4049/jimmunol.160.4.1666 Liu, 2001, Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity, Cell, 106, 259, 10.1016/S0092-8674(01)00456-1 Liu, 2000, T cell activation and polarization by DC1 and DC2, Curr Opin Immunol, 251, 149 Liu, 2005, IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors, Annu Rev Immunol, 23, 275, 10.1146/annurev.immunol.23.021704.115633 Kadowaki, 2001, Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens, Cell, 106, 259 Liu, 2002, Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides, J Exper Med, 195, 695 Dalod, 2002, Interferon alpha/beta and interleukin 12 responses to viral infections: Pathways regulating dendritic cell cytokine expression in vivo, J Exp Med, 195, 517, 10.1084/jem.20011672 Kadowaki, 2000, Natural interferon alpha/beta- producing cells link innate and adaptive immunity, J Exp Med, 192, 219, 10.1084/jem.192.2.219 Siegal, 1999, The nature of the principal type 1 interferon-producing cells in human blood, Science, 284, 1835, 10.1126/science.284.5421.1835 Ito, 2005, Plasmacytoid dendritic cell precursors/type I interferon- producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9, Springer Semin Immunopathol, 26, 221, 10.1007/s00281-004-0180-4 Li, 1999, Antiviral effects of rhIFN-alpha 1 against seven influenza viruses, Chung-Kuo Yao Li Hsueh Pao—Acta Pharmacolo Sinica, 20, 709 Sareneva, 1998, Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells, J Immunol, 160, 6032, 10.4049/jimmunol.160.12.6032 Thompson, 2003, Mortality associated with influenza and respiratory syncytial virus in the United States, J Am Med Assoc, 289, 179, 10.1001/jama.289.2.179 Makinodan, 1976, Reduced humoral immune activity in long-lived old mice: an approach to elucidating its mechanisms, Immunology, 31, 903 Makinodan, 1976, Immunobiology of aging, J Am Geriatr Soc, 24, 249, 10.1111/j.1532-5415.1976.tb03299.x Agrawal, 2008, Biology of dendritic cells in aging, J Clin Immunol, 28, 14, 10.1007/s10875-007-9127-6 Della Bella, 2007, Peripheral blood dendritic cells and monocytes are differently regulated in the elderly, Clin Immunol, 122, 220, 10.1016/j.clim.2006.09.012 Agrawal, 2007, Altered innate immune functioning of dendritic cells in elderly humans: A role of phosphoinositide 3-kinase-signaling pathway, J Immunol, 178, 6912, 10.4049/jimmunol.178.11.6912 Lung, 2000, Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells, Vaccine, 18, 1606, 10.1016/S0264-410X(99)00494-6 Shodell, 2002, Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing, Scand J Immunol, 56, 518, 10.1046/j.1365-3083.2002.01148.x Perez-Cabezas, 2007, Reduced numbers of plasmacytoid dendritic cells in aged blood donors, Exp Gerontol, 42, 1033, 10.1016/j.exger.2007.05.010 Deng, 2004, Age-related impaired type 1 T cell responses to influenza: Reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly, J Immunol, 172, 3437, 10.4049/jimmunol.172.6.3437 Rockwood, 2005, A global clinical measure of fitness and frailty in elderly people, Can Med Assoc J, 173, 489, 10.1503/cmaj.050051 Mazariegos, 2003, Dendritic cells subset ratio in peripheral blood correlates wuth sucessful withdrawal of immunesupression in liver trasplant patients, Am. J Transplant, 3, 689, 10.1034/j.1600-6143.2003.00109.x Lennette, 1995 Li, 2000, Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells, Blood, 96, 2828, 10.1182/blood.V96.8.2828 Ito, 2002, Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets, J Exp Med, 195, 1507, 10.1084/jem.20020207 Kadowaki, 2001, Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens, J Exp Med, 194, 863, 10.1084/jem.194.6.863 Teig, 2002, Age-related changes in human blood dendritic cell subpopulations, Scand J Immunol, 55, 453, 10.1046/j.1365-3083.2002.01068.x Vakkila, 2004, Dendritic cell subsets in childhood and in children with cancer: relation to age and disease prognosis, Clin Exp Immunol, 135, 455, 10.1111/j.1365-2249.2003.02388.x Bauer, 2001, Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition, Proc Natl Acad Sci U S A, 98, 9237, 10.1073/pnas.161293498 Kirschning, 2001, Toll-like receptors: Cellular signal transducers for exogenous molecular patterns causing immune responses, Int J Med Microbiol, 291, 251, 10.1078/1438-4221-00128 van Duin, 2007, Age-associated defect in human TLR-1/2 function, J Immunol, 178, 970, 10.4049/jimmunol.178.2.970 van Duin, 2007, Toll-like receptors in older adults, J Am Geriatr Soc, 55, 1438, 10.1111/j.1532-5415.2007.01300.x Renshaw, 2002, Cutting edge: impaired Toll-like receptor expression and function in aging, J Immunol, 169, 4697, 10.4049/jimmunol.169.9.4697 Mohty, 2003, IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities, J Immunol, 171, 3385, 10.4049/jimmunol.171.7.3385 Hornung, 2002, Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides, J Immunol, 168, 4531, 10.4049/jimmunol.168.9.4531 Siegal FP, Spear GT. Innate immunity and HIV. AIDS 2001; (15 Suppl 5):S127–37. Siegal, 1986, Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity, J Clin Invest, 78, 115, 10.1172/JCI112539 Morse, 2002, Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants, J Hematother Stem Cell Res, 11, 659, 10.1089/15258160260194802 Soumelis, 2006, From plasmacytoid to dendritic cell: Morphological and functional switches during plasmacytoid pre-dendritic cell differentiation, Eur J Immunol, 36, 2286, 10.1002/eji.200636026 Shortman, 1997, Dendritic cell development: Multiple pathways to nature's adjuvants, Stem Cells, 15, 409, 10.1002/stem.150409 Corcoran, 2003, The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells, J Immunol, 170, 4926, 10.4049/jimmunol.170.10.4926 Bendriss-Vermare, 2001, Human thymus contains IFN-alpha-producing CD11c(−), myeloid CD11c(+), and mature interdigitating dendritic cells, J Clin Invest, 107, 835, 10.1172/JCI11734 Spits, 2000, Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1, J Exp Med, 192, 1775, 10.1084/jem.192.12.1775 Steger, 1996, Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals, Clin Exp Immunol, 105, 544, 10.1046/j.1365-2249.1996.d01-790.x Lung, 2000, Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells, Vaccine, 18, 1606, 10.1016/S0264-410X(99)00494-6