Gut microbiota-mediated pharmacokinetics of ginseng saponins
Tài liệu tham khảo
Kim, 2012, Chemical diversity of Panax ginseng, Panax quinquefolius, and Panax notoginseng, J Ginseng Res, 36, 1, 10.5142/jgr.2012.36.1.1
Mikov, 1994, The metabolism of drugs by the gut flora, Eur J Drug Metab Pharmacokinet, 19, 201, 10.1007/BF03188922
Sousa, 2008, The gastrointestinal microbiota as a site for the biotransformation of drugs, Int J Pharm, 363, 1, 10.1016/j.ijpharm.2008.07.009
Kim, 2012, The possible role of intestinal microflora in pharmacological activities of ginseng, Int Biomed Pharmaceut Sci, 6, 90
Kobashi, 1987, Relation of intestinal bacteria to pharmacological effects of glycosides, Biosci Microflora, 16, 1, 10.12938/bifidus1996.16.1
Fanaro, 2003, Intestinal microflora in early infancy: composition and development, Acta Paediatr Suppl, 91, 48
Dominguez-Bello, 2010, Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns, Proc Natl Acad Sci USA, 107, 11971, 10.1073/pnas.1002601107
Eckburg, 2005, Diversity of the human intestinal microbial flora, Science, 308, 1635, 10.1126/science.1110591
Lozupone, 2012, Diversity, stability and resilience of the human gut microbiota, Nature, 489, 220, 10.1038/nature11550
Cho, 2012, The human microbiome: at the interface of health and disease, Nat Rev Genet, 13, 260, 10.1038/nrg3182
Li, 1973, An introductory note to ginseng, Am J Chin Med, 1, 249, 10.1142/S0192415X73000279
Banskota, 2003, Chemical constituents and biological activities of Vietnamese medicinal plants, Curr Top Med Chem, 3, 227, 10.2174/1568026033392516
Chen, 2008, Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium, Acta Pharmacol Sin, 29, 1103, 10.1111/j.1745-7254.2008.00868.x
Ng, 2006, Pharmacological activity of sanchi ginseng (Panax notoginseng), J Pharm Pharmacol, 58, 1007, 10.1211/jpp.58.8.0001
Garriques, 1954, On panaquilon, a new vegetable substance, Ann Chem Pharm, 90, 231
Shibata, 1963, Studies on the constituents of Japanese and Chinese crude drugs. XII. Panaxadiol, a sapogenin of ginseng roots, Chem Pharm Bull, 11, 762, 10.1248/cpb.11.762
Shibata, 1965, Saponins and sapogenins of Panax ginseng C.A. Meyer and some other Panax spp., Yakugaku Zasshi, 85, 753
Shibata, 1965, Studies on saponins and sapogenis of ginseng. The structure of panaxatriol, Tetrahedron Lett, 42, 207, 10.1016/S0040-4039(01)99595-4
Baek, 2012, Recent methodology in ginseng analysis, J Ginseng Res, 36, 119, 10.5142/jgr.2012.36.2.119
Ru, 2015, Chemical constituents and bioactivities of Panax ginseng (C.A. Mey.), Drug Discov Ther, 9, 23, 10.5582/ddt.2015.01004
Shibata, 1963, Studies on the constituents of Japanese and Chinese crude drugs. XI. Panaxadiol, a sapogenin of ginseng roots, Chem Pharm Bull (Tokyo), 11, 759, 10.1248/cpb.11.759
Kitagawa, 1987, Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root, Yakugaku Zasshi, 107, 495, 10.1248/yakushi1947.107.7_495
Kitagawa, 1983, Chemical studies on crude drug precession. I. On the constituents of ginseng radix rubra (1), Yakugaku Zasshi, 103, 612, 10.1248/yakushi1947.103.6_612
Ruan, 2010, Isolation and characterization of a new ginsenoside from the fresh root of Panax ginseng, Molecules, 15, 2319, 10.3390/molecules15042319
Zhu, 2011, Protopanaxatriol-type ginsenosides from the root of Panax ginseng, Agric Food Chem, 59, 200, 10.1021/jf1037932
Besso, 1982, Ginsenoside Ra1 and ginsenoside Ra2, new dammarane-saponins of ginseng roots, Chem Pharm Bull, 30, 2380, 10.1248/cpb.30.2380
Kasai, 1983, Saponins of red ginseng, Chem Pharm Bull, 31, 2120, 10.1248/cpb.31.2120
Ryu, 1996, A genuine dammarane glycoside, (20E)-ginsenoside F4 from Korean red ginseng, Arch Pharm Res, 19, 335, 10.1007/BF02976251
Baek, 1996, Ginsenoside Rh4, a genuine dammarane glycoside from Korean Red Ginseng, Planta Med, 62, 86, 10.1055/s-2006-957816
Anufriev, 1997, Synthesis of ginsenoside Rg3, a minor constituent of ginseng radix, Carbohydr Res, 304, 179, 10.1016/S0008-6215(97)00217-6
Park, 1998, Ginsenoside Rf2, a new dammarane glycoside from Korean red ginseng (Panax ginseng), Arch Pharm Res, 21, 615, 10.1007/BF02975384
Bae, 2004, Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants, Arch Pharm Res, 27, 61, 10.1007/BF02980048
Han, 1982, Degradation of ginseng saponins under mild acidic conditions, Planta Med, 44, 146, 10.1055/s-2007-971425
Kown, 2001, Liquid chromatographic determination of less polar ginsenosides in processed ginseng, J Chromatogr A, 921, 335, 10.1016/S0021-9673(01)00869-X
Taniyasu, 1982, Dammarane saponins of flower buds of Panax notoginseng (sanchi-ginseng), Planta Med, 44, 124, 10.1055/s-2007-971420
Yu, 2013, Chemical constituents from processed rhizomes of Panax notoginseng, Zhongguo Zhong Yao Za Zhi, 38, 3910
Zeng, 2007, Studies on chemical constituents from rhizomes of Panax notoginseng, Zhong Yao Cai, 30, 1388
Zhou, 1981, Dammarane-saponins of sanchi-ginseng, roots of Panax notoginseng (BURK.) F.H. CHEN (Araliaceae): structures of new saponins, notoginsenosides-R1 and -R2, and identification of ginsenosides-Rg2 and -Rh1, Chem Pharm Bull, 29, 2844, 10.1248/cpb.29.2844
Zhao, 1996, Minor dammarane saponins from Panax notoginseng, Phytochemistry, 41, 1419, 10.1016/0031-9422(95)00785-7
Nguyen, 1993, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. I, Chem Pharm Bull (Tokyo), 41, 2010, 10.1248/cpb.41.2010
Nguyen, 1994, Saponins from Vietnamese ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II, Chem Pharm Bull, 42, 634, 10.1248/cpb.42.634
Duc, 1994, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III, Chem Pharm Bull (Tokyo), 42, 115, 10.1248/cpb.42.115
Tawab, 2003, Degradation of ginsenosides in humans after oral administration, Drug Metab Disp, 31, 1065, 10.1124/dmd.31.8.1065
Akao, 1998, Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng, J Pharm Pharmacol, 50, 1155, 10.1111/j.2042-7158.1998.tb03327.x
Akao, 1998, Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration—measurement of compound K by enzyme immunoassay, Biol Pharm Bull, 21, 245, 10.1248/bpb.21.245
Shibata, 2001, Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds, J Kor Med Sci, 16, S28, 10.3346/jkms.2001.16.S.S28
Kim, 2014, Effect of a soluble prebiotic fiber, NUTRIOSE, on the absorption of ginsenoside Rd in rats orally administered ginseng, J Ginseng Res, 38, 203, 10.1016/j.jgr.2014.03.003
Kim, 2015, A prebiotic fiber increases the formation and subsequent absorption of compound K following oral administration of ginseng in rats, J Ginseng Res, 39, 183, 10.1016/j.jgr.2014.11.002
Lee, 2009, Studies on absorption, distribution and metabolism of ginseng in humans after oral administration, J Ethnopharmacol, 122, 143, 10.1016/j.jep.2008.12.012
Hasegawa, 1996, Main ginseng metabolites formed by intestinal bacteria, Planta Med, 62, 453, 10.1055/s-2006-957938
Karikura, 1990, Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats, Chem Pharm Bull, 38, 2859, 10.1248/cpb.38.2859
Odani, 1983, Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II. The absorption, distribution and excretion of ginsenoside Rg1 in the rat, Chem Pharm Bull, 31, 292, 10.1248/cpb.31.292
Strömbom, 1985, Studies on absorption and distribution of ginsenoside Rg1 by whole-body autoradiobiography and chromatography, Acta Pharmaceut Suecica, 22, 113
Park, 2005, Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide, Biol Pharm Bull, 28, 652, 10.1248/bpb.28.652
Kato, 1990, Determination of ginsenoside Rb1 in plasma of human after intake of red ginseng powder, 36
Scalbert, 2000, Dietary intake and bioavailability of polyphenols, J Nutri, 130, 2073S
Bae, 2000, Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria, Biol Pharm Bull, 23, 1481, 10.1248/bpb.23.1481
Bae, 2002, Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities, Biol Pharm Bull, 25, 58, 10.1248/bpb.25.58
Bae, 2002, Metabolism of ginsenoside Rc and its related antiallergic activity, Biol Pharm Bull, 25, 743, 10.1248/bpb.25.743
Kim, 2009, Metabolism of ginsenosides to bioactive compounds by intestinal microflora and its industrial application, J Ginseng Res, 33, 165, 10.5142/JGR.2009.33.3.165
Park, 2001, Purification and characterization of ginsenoside Rb1-metabolizing beta-glucosidase from Fusobacterium K-60, a human intestinal anaerobic bacterium, Biosci Biotechnol Biochem, 65, 1163, 10.1271/bbb.65.1163
Shin, 2003, Purification and characterization of ginsenoside Ra-hydrolyzing beta-D-xylosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium, Biol Pharm Bull, 26, 1170, 10.1248/bpb.26.1170
Bae, 2005, Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect, Biol Pharm Bull, 28, 1903, 10.1248/bpb.28.1903
Jeong, 2015, Anti-inflammatory effects of vina-ginsenoside R2 and majonoside R2 isolated from Panax vietnamensis and their metabolites in lipopolysaccharide-stimulated macrophages, Int Immunopharmacol, 28, 700, 10.1016/j.intimp.2015.07.025
Lee, 2015, Ocotillol, a majonoside R2 metabolite, ameliorates 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by restoring the balance of Th17/Treg cells, J Agric Food Chem, 63, 7024, 10.1021/acs.jafc.5b02183
Wakabayashi, 1998, In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration, Oncol Res, 9, 411
Hasegawa, 2000, Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters, Biol Pharm Bull, 23, 298, 10.1248/bpb.23.298
Attele, 1999, Ginseng pharmacology: multiple constituents and multiple actions, Biochem Pharmacol, 58, 1685, 10.1016/S0006-2952(99)00212-9
Kennedy, 2003, Ginseng: potential for the enhancement of cognitive performance and mood, Pharmacol Biochem Behav, 75, 687, 10.1016/S0091-3057(03)00126-6
Scaglione, 1990, Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer, Drug Exp Clin Res, 16, 537
Singh, 1984, Immunomodulatory activity of Panax ginseng extract, Planta Med, 50, 462, 10.1055/s-2007-969773
Matsuda, 1986, Pharmacological study on Panax ginseng C.A. Meyer. IV. Effects of red ginseng on experimental disseminated intravascular coagulation. (3). Effect of ginsenoside-Ro on the blood coagulative and fibrinolytic system, Chem Pharm Bull, 34, 2100, 10.1248/cpb.34.2100
Yokozawa, 1985, Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats, Chem Pharm Bull, 33, 869, 10.1248/cpb.33.869
Xie, 2005, Anti-diabetic effect of ginsenoside Re in ob/ob mice, Biochim Biophys Acta, 1740, 319, 10.1016/j.bbadis.2004.10.010
Chang, 2003, Panax ginseng: a role in cancer therapy?, Integr Cancer Therap, 2, 13, 10.1177/1534735403251167
Helms, 2004, Cancer prevention and therapeutics: Panax ginseng, Altern Med Rev, 9, 259
Choo, 2003, Antiallergic activity of ginseng and its ginsenosides, Planta Med, 69, 518, 10.1055/s-2003-40653
Park, 2003, Antiallergic activity of ginsenoside Rh2, Biol Pharm Bull, 26, 1581, 10.1248/bpb.26.1581
Park, 2004, Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities, Int Arch Allergy Immunol, 133, 113, 10.1159/000076383
Kim, 1999, The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: role of K+ channels, Eur J Pharmacol, 367, 51, 10.1016/S0014-2999(98)00899-1
Park, 2004, Ginsenoside Rh2 reduces ischemic brain injury in rats, Biol Pharm Bull, 27, 433, 10.1248/bpb.27.433
Shieh, 2008, Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes, Neurosci Lett, 434, 1, 10.1016/j.neulet.2007.12.032
Su, 2014, Ginsenoside Re as an adjuvant to enhance the immune response to the inactivated rabies virus vaccine in mice, Int Immunopharmacol, 20, 283, 10.1016/j.intimp.2014.03.008
Lee, 2004, Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation, Int Immunopharmacol, 4, 235, 10.1016/j.intimp.2003.12.007
Lee, 2000, Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease, Biochem Pharmacol, 60, 677, 10.1016/S0006-2952(00)00362-2
Tatsuka, 2001, Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh(2), Jpn J Cancer Res, 92, 1184, 10.1111/j.1349-7006.2001.tb02138.x
Shin, 2005, Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models, J Pharm Sci, 99, 83, 10.1254/jphs.FP0050260
Shin, 2005, Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis, Int Immunopharmacol, 5, 1183, 10.1016/j.intimp.2005.02.016
Choo, 2008, A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappa B signaling in murine colon cancer cells, Oncol Rep, 19, 595
Cui, 1997, Gas chromatographic-mass spectrometric determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations, J Chromatogr B Biomed Sci Appl, 689, 349, 10.1016/S0378-4347(96)00304-0
Bae, 2004, Protective effect of fermented red ginseng on a transient focal ischemic rats, Arch Pharm Res, 27, 1136, 10.1007/BF02975119
Kim, 2013, Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K, PLoS One, 8, e62409, 10.1371/journal.pone.0062409
Lee, 2002, Fecal metabolic activities of herbal components to bioactive compounds, Arch Pharm Res, 25, 165, 10.1007/BF02976558
Yim, 2004, Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora, Biol Pharm Bull, 27, 1580, 10.1248/bpb.27.1580
Choi, 2011, Metabolic activities of ginseng and its constituents, ginsenoside rb1 and rg1, by human intestinal microflora, J Ginseng Res, 35, 301, 10.5142/jgr.2011.35.3.301
Kim, 2002, Herbal medicines are activated by intestinal microflora, Nat Prod Sci, 8, 35
Kim, 2015, Gut microbiota-mediated drug-antibiotic interactions, Drug Metab Dispos, 43, 1581, 10.1124/dmd.115.063867
Tamura, 1980, Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora, Proc Natl Acad Sci USA, 77, 4961, 10.1073/pnas.77.8.4961
Kobashi, 1984, Relation of intestinal microflora to Syo, Wakan-iyaku-kaishi, 1, 166
Trinh, 2007, Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng, J Microbiol Biotechnol, 17, 1127