Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

Atarashi, 2011, Induction of colonic regulatory T cells by indigenous Clostridium species, Science, 331, 337, 10.1126/science.1198469

Atarashi, 2013, Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota, Nature, 500, 232, 10.1038/nature12331

Blasius, 2006, Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12, Blood, 107, 2474, 10.1182/blood-2005-09-3746

Bouma, 2003, The immunological and genetic basis of inflammatory bowel disease, Nat. Rev. Immunol., 3, 521, 10.1038/nri1132

Chen, 2008, The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation, J. Immunol., 181, 5396, 10.4049/jimmunol.181.8.5396

Cobb, 2004, Polysaccharide processing and presentation by the MHCII pathway, Cell, 117, 677, 10.1016/j.cell.2004.05.001

Colvin, 2009, Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression, Hum. Immunol., 70, 313, 10.1016/j.humimm.2009.01.021

Creusot, 2009, Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells, Blood, 113, 6638, 10.1182/blood-2009-02-204321

Fallarino, 2004, Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement, J. Immunol., 173, 3748, 10.4049/jimmunol.173.6.3748

Goubier, 2008, Plasmacytoid dendritic cells mediate oral tolerance, Immunity, 29, 464, 10.1016/j.immuni.2008.06.017

Greenwald, 2005, The B7 family revisited, Annu. Rev. Immunol., 23, 515, 10.1146/annurev.immunol.23.021704.115611

Hadeiba, 2012, Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance, Immunity, 36, 438, 10.1016/j.immuni.2012.01.017

Hall, 2008, Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses, Immunity, 29, 637, 10.1016/j.immuni.2008.08.009

Irla, 2010, MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity, J. Exp. Med., 207, 1891, 10.1084/jem.20092627

Ito, 2007, Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand, J. Exp. Med., 204, 105, 10.1084/jem.20061660

Kanai, 2001, Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease, Gastroenterology, 121, 875, 10.1053/gast.2001.28021

Kassner, 2010, Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis, J. Immunol., 184, 550, 10.4049/jimmunol.0903152

Katakura, 2005, Toll-like receptor 9-induced type I IFN protects mice from experimental colitis, J. Clin. Invest., 115, 695, 10.1172/JCI22996

Leon, 2006, Antibodies to complement receptor 3 treat established inflammation in murine models of colitis and a novel model of psoriasiform dermatitis, J. Immunol., 177, 6974, 10.4049/jimmunol.177.10.6974

Lombardi, 2012, CD8α+β− and CD8α+β+ plasmacytoid dendritic cells induce Foxp3+ regulatory T cells and prevent the induction of airway hyper-reactivity, Mucosal Immunol., 5, 432, 10.1038/mi.2012.20

Maldonado, 2010, How tolerogenic dendritic cells induce regulatory T cells, Adv. Immunol., 108, 111, 10.1016/B978-0-12-380995-7.00004-5

Manches, 2008, HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism, J. Clin. Invest., 118, 3431, 10.1172/JCI34823

Martín-Gayo, 2010, Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development, Blood, 115, 5366, 10.1182/blood-2009-10-248260

Mazmanian, 2005, An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system, Cell, 122, 107, 10.1016/j.cell.2005.05.007

Mazmanian, 2008, A microbial symbiosis factor prevents intestinal inflammatory disease, Nature, 453, 620, 10.1038/nature07008

Meyer Zu Hörste, 2010, Active immunization induces toxicity of diphtheria toxin in diphtheria resistant mice—implications for neuroinflammatory models, J. Immunol. Methods, 354, 80, 10.1016/j.jim.2010.01.012

Miller, 2012, Deciphering the transcriptional network of the dendritic cell lineage, Nat. Immunol., 13, 888, 10.1038/ni.2370

Ochoa-Repáraz, 2010, A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease, Mucosal Immunol., 3, 487, 10.1038/mi.2010.29

Pabst, 2012, Oral tolerance to food protein, Mucosal Immunol., 5, 232, 10.1038/mi.2012.4

Palmen, 1995, Anti-CD11b/CD18 antibodies reduce inflammation in acute colitis in rats, Clin. Exp. Immunol., 101, 351, 10.1111/j.1365-2249.1995.tb08363.x

Round, 2010, Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota, Proc. Natl. Acad. Sci. USA, 107, 12204, 10.1073/pnas.0909122107

Round, 2011, The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota, Science, 332, 974, 10.1126/science.1206095

Ruiz-Perez, 2005, Modulation of surgical fibrosis by microbial zwitterionic polysaccharides, Proc. Natl. Acad. Sci. USA, 102, 16753, 10.1073/pnas.0505688102

Sharma, 2007, Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase, J. Clin. Invest., 117, 2570, 10.1172/JCI31911

Shen, 2012, Outer membrane vesicles of a human commensal mediate immune regulation and disease protection, Cell Host Microbe, 12, 509, 10.1016/j.chom.2012.08.004

Smith, 2013, The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis, Science, 341, 569, 10.1126/science.1241165

Spahn, 2001, Induction of oral tolerance to cellular immune responses in the absence of Peyer’s patches, Eur. J. Immunol., 31, 1278, 10.1002/1521-4141(200104)31:4<1278::AID-IMMU1278>3.0.CO;2-A

Steinman, 2003, Tolerogenic dendritic cells, Annu. Rev. Immunol., 21, 685, 10.1146/annurev.immunol.21.120601.141040

Stephen, 2005, Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation, Infect. Immun., 73, 2184, 10.1128/IAI.73.4.2184-2189.2005

Stromnes, 2006, Active induction of experimental allergic encephalomyelitis, Nat. Protoc., 1, 1810, 10.1038/nprot.2006.285

Swiecki, 2010, Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance, Immunol. Rev., 234, 142, 10.1111/j.0105-2896.2009.00881.x

Swiecki, 2010, Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual, Immunity, 33, 955, 10.1016/j.immuni.2010.11.020

te Velde, 2006, Critical appraisal of the current practice in murine TNBS-induced colitis, Inflamm. Bowel Dis., 12, 995, 10.1097/01.mib.0000227817.54969.5e

Tzianabos, 1992, The capsular polysaccharide of Bacteroides fragilis comprises two ionically linked polysaccharides, J. Biol. Chem., 267, 18230, 10.1016/S0021-9258(19)37177-7

Wang, 2006, A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2, J. Exp. Med., 203, 2853, 10.1084/jem.20062008

Wirtz, 2007, Chemically induced mouse models of intestinal inflammation, Nat. Protoc., 2, 541, 10.1038/nprot.2007.41

Worbs, 2006, Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells, J. Exp. Med., 203, 519, 10.1084/jem.20052016

Young, 2008, Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells, Nat. Immunol., 9, 1244, 10.1038/ni.1665

Zhang, 2006, Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors, Blood, 107, 3600, 10.1182/blood-2005-09-3842