Vascular Senescence in Cardiovascular and Metabolic Diseases

Goro Katsuumi1, Ippei Shimizu1,2, Yohko Yoshida1,2, Tohru Minamino1
1Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan
2Division of Molecular Aging and Cell Biology, Niigata University Graduate School of Medical and Dental Sciences, Japan

Tóm tắt

Từ khóa


Tài liệu tham khảo

López-Otín, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039

de Cabo, 2014, The search for antiaging interventions: from elixirs to fasting regimens, Cell, 157, 1515, 10.1016/j.cell.2014.05.031

Shimizu, 2014, DNA damage response and metabolic disease, Cell Metab, 20, 967, 10.1016/j.cmet.2014.10.008

van Deursen, 2014, The role of senescent cells in ageing, Nature, 509, 439, 10.1038/nature13193

Childs, 2015, Cellular senescence in aging and age-related disease: from mechanisms to therapy, Nat Med, 21, 1424, 10.1038/nm.4000

Hayflick, 1961, The serial cultivation of human diploid cell strains, Exp Cell Res, 25, 585, 10.1016/0014-4827(61)90192-6

Tchkonia, 2013, Cellular senescence and the senescent secretory phenotype: therapeutic opportunities, J Clin Invest, 123, 966, 10.1172/JCI64098

Wang, 2012, Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence, Circ Res, 111, 245, 10.1161/CIRCRESAHA.111.261388

Gogiraju, 2015, Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice, J Am Heart Assoc, 4, 10.1161/JAHA.115.001770

Yoshida, 2015, p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload, J Mol Cell Cardiol, 85, 183, 10.1016/j.yjmcc.2015.06.001

Yokoyama, 2014, Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity, Cell Rep, 7, 1691, 10.1016/j.celrep.2014.04.046

Stewart, 2006, Telomeres: cancer to human aging, Annu Rev Cell Dev Biol, 22, 531, 10.1146/annurev.cellbio.22.010305.104518

Lane, 1992, Cancer. p53, guardian of the genome, Nature, 358, 15, 10.1038/358015a0

Green, 2006, p53 and metabolism: Inside the TIGAR, Cell, 126, 30, 10.1016/j.cell.2006.06.032

Sano, 2007, p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload, Nature, 446, 444, 10.1038/nature05602

Beauséjour, 2003, Reversal of human cellular senescence: roles of the p53 and p16 pathways, Embo J, 22, 4212, 10.1093/emboj/cdg417

Campisi, 2005, Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors, Cell, 120, 513, 10.1016/j.cell.2005.02.003

Jacobs, 2004, Significant role for p16INK4a in p53-independent telomere-directed senescence, Curr Biol, 14, 2302, 10.1016/j.cub.2004.12.025

Donato, 2015, Cellular and molecular biology of aging endothelial cells, J Mol Cell Cardiol, 89, 122, 10.1016/j.yjmcc.2015.01.021

Varela, 2005, Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation, Nature, 437, 564, 10.1038/nature04019

Minamino, 2009, A crucial role for adipose tissue p53 in the regulation of insulin resistance, Nat Med, 15, 1082, 10.1038/nm.2014

Sahin, 2011, Telomere dysfunction induces metabolic and mitochondrial compromise, Nature, 470, 359, 10.1038/nature09787

Shimizu, 2012, p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure, Cell Metab, 15, 787, 10.1016/j.cmet.2012.04.014

Shimizu, 2013, Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity, Cell Metab, 18, 491, 10.1016/j.cmet.2013.09.001

Vousden, 2009, Blinded by the light: the growing complexity of p53, Cell, 137, 413, 10.1016/j.cell.2009.04.037

Sahin, 2012, Axis of ageing: telomeres, p53 and mitochondria, Nat Rev Mol Cell Biol, 13, 397, 10.1038/nrm3352

Matheu, 2007, Delayed ageing through damage protection by the Arf/p53 pathway, Nature, 448, 375, 10.1038/nature05949

García-Cao, 2002, "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally, Embo J, 21, 6225, 10.1093/emboj/cdf595

Tomás-Loba, 2008, Telomerase reverse transcriptase delays aging in cancer-resistant mice, Cell, 135, 609, 10.1016/j.cell.2008.09.034

Franck, 2013, Glucose tolerance in mice is linked to the dose of the p53 transactivation domain, Endocr Res, 38, 139, 10.3109/07435800.2012.735735

Baker, 2013, p21 both attenuates and drives senescence and aging in BubR1 progeroid mice, Cell Rep, 3, 1164, 10.1016/j.celrep.2013.03.028

Baker, 2012, Opposing roles for p16(Ink4a) and p19(Arf) in senescence and ageing caused by BubR1 insufficiency (vol 10, pg 825, 2008), Nat Cell Biol, 14, 10.1038/ncb2519

Baker, 2016, Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan, Nature, 530, 184, 10.1038/nature16932

Chang, 2016, Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice, Nat. Med., 22, 78, 10.1038/nm.4010

Nelson, 2012, A senescent cell bystander effect: senescence-induced senescence, Aging Cell, 11, 345, 10.1111/j.1474-9726.2012.00795.x

Dimri, 1995, A biomarker that identifies senescent human cells in culture and in aging skin in vivo, Proc Natl Acad Sci USA, 92, 9363, 10.1073/pnas.92.20.9363

Iwasa, 2003, Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway, Genes Cells, 8, 131, 10.1046/j.1365-2443.2003.00620.x

Minamino, 2007, Vascular cell senescence: contribution to atherosclerosis, Circ Res, 100, 15, 10.1161/01.RES.0000256837.40544.4a

Muñoz-Espín, 2014, Cellular senescence: from physiology to pathology, Nat Rev Mol Cell Biol, 15, 482, 10.1038/nrm3823

Salama, 2014, Cellular senescence and its effector programs, Genes Dev, 28, 99, 10.1101/gad.235184.113

Borlaug, 2014, The pathophysiology of heart failure with preserved ejection fraction, Nat Rev Cardiol, 11, 507, 10.1038/nrcardio.2014.83

Lakatta, 1993, Cardiovascular regulatory mechanisms in advanced age, Physiol Rev, 73, 413, 10.1152/physrev.1993.73.2.413

Shih, 2011, The aging heart and post-infarction left ventricular remodeling, J Am Coll Cardiol, 57, 9, 10.1016/j.jacc.2010.08.623

Mohammed, 2015, Response to letters regarding article, "coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction", Circulation, 132, 10.1161/CIRCULATIONAHA.115.017050

Paulus, 2013, A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation, J Am Coll Cardiol, 62, 263, 10.1016/j.jacc.2013.02.092

Gevaert, 2017, Endothelial senescence contributes to heart failure with preserved ejection fraction in an aging mouse model, Circ Heart Fail, 10, 10.1161/CIRCHEARTFAILURE.116.003806

Frieler, 2015, Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling, Circulation, 131, 1019, 10.1161/CIRCULATIONAHA.114.008788

Cohn, 1984, Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure, N Engl J Med, 311, 819, 10.1056/NEJM198409273111303

van Heerebeek, 2006, Myocardial structure and function differ in systolic and diastolic heart failure, Circulation, 113, 1966, 10.1161/CIRCULATIONAHA.105.587519

Kasner, 2011, Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction, J Am Coll Cardiol, 57, 977, 10.1016/j.jacc.2010.10.024

Selby, 2011, Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction, J Am Coll Cardiol, 58, 147, 10.1016/j.jacc.2010.10.069

Lakatta, 2003, Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease, Circulation, 107, 139, 10.1161/01.CIR.0000048892.83521.58

Lakatta, 2013, The reality of aging viewed from the arterial wall, Artery Res, 7, 73, 10.1016/j.artres.2013.01.003

Spina, 1983, Age-related changes in composition and mechanical properties of the tunica media of the upper thoracic human aorta, Arteriosclerosis, 3, 64, 10.1161/01.ATV.3.1.64

Gerstenblith, 1977, Echocardiographic assessment of a normal adult aging population, Circulation, 56, 273, 10.1161/01.CIR.56.2.273

Mauriello, 1992, Age-related modification of average volume and anisotropy of vascular smooth muscle cells, Pathol Res Pract, 188, 630, 10.1016/S0344-0338(11)80070-1

Harvey, 2015, Vascular biology of ageing-Implications in hypertension, J Mol Cell Cardiol, 83, 112, 10.1016/j.yjmcc.2015.04.011

Minamino, 2002, Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction, Circulation, 105, 1541, 10.1161/01.CIR.0000013836.85741.17

Marchand, 2011, The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans, Aging Cell, 10, 220, 10.1111/j.1474-9726.2010.00661.x

Cafueri, 2012, Endothelial and smooth muscle cells from abdominal aortic aneurysm have increased oxidative stress and telomere attrition, PLoS ONE, 7, 10.1371/journal.pone.0035312

Morgan, 2013, Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries, Am J Physiol Heart Circ Physiol, 305, H251, 10.1152/ajpheart.00197.2013

Melk, 2004, Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney, Kidney Int., 65, 510, 10.1111/j.1523-1755.2004.00438.x

Yang, 2007, Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence, Aging Cell, 6, 257, 10.1111/j.1474-9726.2007.00274.x

Rajapakse, 2011, Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol, PLoS ONE, 6, 10.1371/journal.pone.0019237

Lin, 2015, Downregulation of dynamin-related protein 1 contributes to impaired autophagic flux and angiogenic function in senescent endothelial cells, Arterioscler Thromb Vasc Biol, 35, 1413, 10.1161/ATVBAHA.115.305706

Satoh, 2008, Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease, Atherosclerosis, 198, 347, 10.1016/j.atherosclerosis.2007.09.040

van der Harst, 2007, Telomere length of circulating leukocytes is decreased in patients with chronic heart failure, J Am Coll Cardiol, 49, 1459, 10.1016/j.jacc.2007.01.027

Haycock, , Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis, BMJ, 349, 10.1136/bmj.g4227

Salpea, 2010, Telomere length in atherosclerosis and diabetes, Atherosclerosis, 209, 35, 10.1016/j.atherosclerosis.2009.12.021

Morgan, 2014, Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping, J Hypertens, 32, 1293, 10.1097/HJH.0000000000000157

Durik, 2012, Nucleotide excision DNA repair is associated with age-related vascular dysfunction, Circulation, 126, 10.1161/CIRCULATIONAHA.112.104380

Westhoff, 2008, Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a, Hypertension, 52, 123, 10.1161/HYPERTENSIONAHA.107.099432

Boe, 2013, Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence, Circulation, 128, 2318, 10.1161/CIRCULATIONAHA.113.003192

Warboys, 2014, Disturbed flow promotes endothelial senescence via a p53-dependent pathway, Arterioscler Thromb Vasc Biol, 34, 985, 10.1161/ATVBAHA.114.303415

Ungvari, 2010, Mechanisms of vascular aging: new perspectives, J Gerontol A Biol Sci Med Sci, 65, 1028, 10.1093/gerona/glq113

Chilton, 2017, Telomeres, aging and exercise: guilty by association?, Int J Mol Sci, 18, 10.3390/ijms18122573

Rossman, 2017, Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function, Am J Physiol Heart Circ Physiol, 313, H890, 10.1152/ajpheart.00416.2017

Faggiotto, 1984, Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation, Arteriosclerosis, 4, 323, 10.1161/01.ATV.4.4.323

Lakatta, 2015, So! What's aging? Is cardiovascular aging a disease?, J Mol Cell Cardiol, 83, 1, 10.1016/j.yjmcc.2015.04.005

Matthews, 2006, Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress, Circ Res, 99, 156, 10.1161/01.RES.0000233315.38086.bc

Kunieda, 2006, Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway, Circulation, 114, 953, 10.1161/CIRCULATIONAHA.106.626606

Miao, 2017, Accumulation of smooth muscle 22α protein accelerates senescence of vascular smooth muscle cells via stabilization of p53 in vitro and in vivo, Arterioscler Thromb Vasc Biol, 37, 1849, 10.1161/ATVBAHA.117.309378

Gardner, 2016, Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α-dependent senescence-associated secretory phenotype, Atherosclerosis, 244, 10.1016/j.atherosclerosis.2015.10.065

Herbert, 2008, Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways, Circ Res, 102, 201, 10.1161/CIRCRESAHA.107.158626

Zhao, 2015, Myocyte enhancer factor 2A regulates hydrogen peroxide-induced senescence of vascular smooth muscle cells via microRNA-143, J Cell Physiol, 230, 2202, 10.1002/jcp.24948

Minamino, 2001, Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation, Mol Cell Biol, 21, 3336, 10.1128/MCB.21.10.3336-3342.2001

Wang, 2015, Vascular smooth muscle cell senescence promotes atherosclerosis and features of plaque vulnerability, Circulation, 132, 1909, 10.1161/CIRCULATIONAHA.115.016457

Haycock, 2014, Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis, BMJ, 349, 10.1136/bmj.g4227

D'Mello, 2015, Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis, Circ Cardiovasc Genet, 8, 82, 10.1161/CIRCGENETICS.113.000485

Cawthon, 2003, Association between telomere length in blood and mortality in people aged 60 years or older, Lancet, 361, 393, 10.1016/S0140-6736(03)12384-7

Calvert, 2011, Leukocyte telomere length is associated with high-risk plaques on virtual histology intravascular ultrasound and increased proinflammatory activity, Arterioscler Thromb Vasc Biol, 31, 2157, 10.1161/ATVBAHA.111.229237

Childs, 2016, Senescent intimal foam cells are deleterious at all stages of atherosclerosis, Science, 354, 472, 10.1126/science.aaf6659

Cudejko, 2011, p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages, Blood, 118, 2556, 10.1182/blood-2010-10-313106

Shimizu, 2012, p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure, Cell Metab, 15, 51, 10.1016/j.cmet.2011.12.006

Prior, 2015, Increased skeletal muscle capillarization independently enhances insulin sensitivity in older adults after exercise training and detraining, Diabetes, 64, 3386, 10.2337/db14-1771

King, 2016, Selective insulin resistance and the development of cardiovascular diseases in diabetes: the 2015 Edwin Bierman award lecture, Diabetes, 65, 1462, 10.2337/db16-0152

Ferrara, 2004, Vascular endothelial growth factor: basic science and clinical progress, Endocr Rev, 25, 581, 10.1210/er.2003-0027

Shimizu, 2014, Vascular rarefaction mediates whitening of brown fat in obesity, J Clin Invest, 124, 2099, 10.1172/JCI71643

Yokoi, 2006, Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells, Diabetes, 55, 1660, 10.2337/db05-1607

Orimo, 2009, Protective role of SIRT1 in diabetic vascular dysfunction, Arterioscler Thromb Vasc Biol, 29, 889, 10.1161/ATVBAHA.109.185694

Hayashi, 2014, Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes, Proc Natl Acad Sci USA, 111, 1168, 10.1073/pnas.1322153111

Lumeng, 2011, Inflammatory links between obesity and metabolic disease, J Clin Invest, 121, 2111, 10.1172/JCI57132

Pillon, 2013, Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications, Am J Physiol Endocrinol Metab, 304, E453, 10.1152/ajpendo.00553.2012

Xu, 2015, Targeting senescent cells enhances adipogenesis and metabolic function in old age, Elife, 4, 10.7554/eLife.12997

Zhu, 2015, The Achilles' heel of senescent cells: from transcriptome to senolytic drugs, Aging Cell, 14, 644, 10.1111/acel.12344

Baar, 2017, Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging, Cell, 169, 132, 10.1016/j.cell.2017.02.031

Roos, 2016, Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice, Aging Cell, 15, 973, 10.1111/acel.12458

Raez, 2013, A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors, Cancer Chemother Pharmacol, 71, 523, 10.1007/s00280-012-2045-1

Kirkland, 2017, Cellular Senescence: A Translational Perspective, EBioMedicine, 21, 21, 10.1016/j.ebiom.2017.04.013

Kirkland, 2017, The clinical potential of senolytic drugs, J Am Geriatr Soc, 65, 2297, 10.1111/jgs.14969

Mattison, 2014, Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates, Cell Metab, 20, 183, 10.1016/j.cmet.2014.04.018

Gao, 2016, Activation of SIRT1 attenuates klotho deficiency-induced arterial stiffness and hypertension by enhancing AMP-activated protein kinase activity, Hypertension, 68, 1191, 10.1161/HYPERTENSIONAHA.116.07709

Chen, 2016, Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm, Circ Res, 119, 1076, 10.1161/CIRCRESAHA.116.308895

Liu, 2016, Calorie restriction protects against experimental abdominal aortic aneurysms in mice, J Exp Med, 213, 2473, 10.1084/jem.20151794

Imai, 2014, NAD+ and sirtuins in aging and disease, Trends Cell Biol, 24, 464, 10.1016/j.tcb.2014.04.002

van der Veer, 2007, Extension of human cell lifespan by nicotinamide phosphoribosyltransferase, J Biol Chem, 282, 10841, 10.1074/jbc.C700018200

Watson, 2017, Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease, Circ Res, 120, 1889, 10.1161/CIRCRESAHA.116.310022

Fan, 2017, Aging-associated metabolic disorder induces Nox2 activation and oxidative damage of endothelial function, Free Radic Biol Med, 108, 940, 10.1016/j.freeradbiomed.2017.05.008

Vendrov, 2017, Attenuated superoxide dismutase 2 activity induces atherosclerotic plaque instability during aging in hyperlipidemic mice, J Am Heart Assoc, 6, 10.1161/JAHA.117.006775

Miyauchi, 2004, Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway, Embo J, 23, 212, 10.1038/sj.emboj.7600045

Lesniewski, 2017, Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways, Aging Cell, 16, 17, 10.1111/acel.12524

Marso, 2016, Liraglutide and cardiovascular outcomes in type 2 diabetes, N Engl J Med, 375, 311, 10.1056/NEJMoa1603827

Yang, 2017, Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress, Atherosclerosis, 264, 1, 10.1016/j.atherosclerosis.2017.07.014

Demaria, 2014, An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA, Dev Cell, 31, 722, 10.1016/j.devcel.2014.11.012

Yosef, 2016, Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL, Nat Commun, 7, 10.1038/ncomms11190

Zhu, 2016, Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors, Aging Cell, 15, 428, 10.1111/acel.12445

Farr, 2017, Targeting cellular senescence prevents age-related bone loss in mice, Nat Med, 23, 1072, 10.1038/nm.4385

Ogrodnik, 2017, Cellular senescence drives age-dependent hepatic steatosis, Nat Commun, 8, 10.1038/ncomms15691

Schafer, 2017, Cellular senescence mediates fibrotic pulmonary disease, Nat Commun, 8, 10.1038/ncomms14532

Zhu, 2017, New agents that target senescent cells: the flavone, fisetin, and the BCL-XLinhibitors, A1331852 and A1155463, Aging, 9, 955, 10.18632/aging.101202

Fuhrmann-Stroissnigg, 2017, Identification of HSP90 inhibitors as a novel class of senolytics, Nat Commun, 8, 10.1038/s41467-017-00314-z

Wang, 2016, Discovery of piperlongumine as a potential novel lead for the development of senolytic agents, Aging, 8, 2915, 10.18632/aging.101100

Samaraweera, 2017, A novel indication for panobinostat as a senolytic drug in NSCLC and HNSCC, Sci Rep, 7, 10.1038/s41598-017-01964-1