Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

PLoS ONE - Tập 5 Số 5 - Trang e10667
Elena Biagi1, Lotta Nylund2,3, Marco Candela1, Rita Ostan4, Laura Bucci4, Elisa Pini4, Janne Nikkilä2, Daniela Monti5, Reetta Satokari3, Claudio Franceschi4, Patrizia Brigidi1, Willem M. de Vos2,6
1Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
2Division of Microbiology and Epidemiology, Department of Basic Veterinary Medicine, University of Helsinki, Helsinki, Finland,
3Functional Foods Forum, University of Turku, Turku, Finland
4Department of Experimental Pathology and CIG-Interdepartmental Center L. Galvani, University of Bologna, Bologna, Italy,
5Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
6Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands

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Tài liệu tham khảo

K Imahori, 1992, How I understand ageing., Nutr Rev, 50, 351, 10.1111/j.1753-4887.1992.tb02477.x

B Kleessen, 1997, Affects of inulin and lactose on fecal microflora, microbial activity and bowel habits in elderly constipated persons., Am J Clin Nutr, 65, 1397, 10.1093/ajcn/65.5.1397

JC Brocklehurst, 1972, Bowel management in the neurologically disabled. The problem of old age., Proc R Soc Med, 65, 66

GT Macfarlane, 1989, Influence of retention time on degradation of pancreatic enzymes by human colonic bacteria grown in a 3-stage continuous culture system., J Appl Bacteriol, 67, 520, 10.1111/j.1365-2672.1989.tb02524.x

R Ostan, 2008, Immunosenescence and immunogenetics of human longevity., Neuroimmunomodulation, 15, 224, 10.1159/000156466

C Franceschi, 2007, Inflammaging as a major characteristic of old people: can it be prevented or cured?, Nutr Rev, 65, S173, 10.1301/nr.2007.dec.S173-S176

C Franceschi, 2007, Inflammaging and anti-inflammaging: systemic perspective on aging and longevity emerging from studies in humans., Mech Ageing Dev, 128, 92, 10.1016/j.mad.2006.11.016

A Larbi, 2008, Aging of the immune system as a prognostic factor for human longevity., Physiology, 23, 64, 10.1152/physiol.00040.2007

AS Neish, 2009, Microbes in gastrointestinal health and disease., Gastroenterology, 136, 65, 10.1053/j.gastro.2008.10.080

Y Guigoz, 2008, The inflammatory status of old age can be nurtured from the intestinal environment., Curr Op Clin Nutr Metab Care, 11, 13, 10.1097/MCO.0b013e3282f2bfdf

HJ Flint, 2007, Interactions and competition within the microbial community of the human colon: links between diet and health., Environ Microbiol, 9, 1101, 10.1111/j.1462-2920.2007.01281.x

EJ Woodsmansey, 2007, Intestinal bacteria and ageing., J Appl Micriobiol, 102, 1178, 10.1111/j.1365-2672.2007.03400.x

MJ Hopkins, 2002, Changes in predominant bacterial populations in human feces with age and with <italic>Clostridium difficile</italic> infection., Microb Ecol, 51, 448

S Bartosch, 2004, Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real time PCR and effects of antibiotic treatment on the fecal microbiota., Appl Environ Microbiol, 70, 3575, 10.1128/AEM.70.6.3575-3581.2004

EJ Woodsmansey, 2004, Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic treated elderly subjects., Appl Environ Microbiol, 70, 6113, 10.1128/AEM.70.10.6113-6122.2004

S Mueller, 2006, Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study., Appl Environ Microbiol, 72, 1027, 10.1128/AEM.72.2.1027-1033.2006

D Mariat, 2009, The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age., BMC Microbiol, 9, 123, 10.1186/1471-2180-9-123

R Satokari, 2010, Probiotics and prebiotics in the elderly individuals., 341

EG Zoetendal, 2008, High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota., Gut, 57, 1605, 10.1136/gut.2007.133603

M Rajilic-Stojanovic, 2009, Development an application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults., 10.1111/j.1462-2920.2009.01900.x

MJ Claesson, 2009, Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine., PLoS ONE, 4, e6669, 10.1371/journal.pone.0006669

C Franceschi, 2000, Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE)., Aging, 12, 77

KR Clarke, 1993, Non-parametric multivariate analyses of changes in community structure., Aust J Ecol, 18, 117, 10.1111/j.1442-9993.1993.tb00438.x

RE Ley, 2006, Human gut microbes associated with obesity., Nature, 444, 1022, 10.1038/4441022a

AF Andersson, 2008, Comparative analysis of human gut microbiota by barcoded pyrosequencing., PloS ONE, 3, e2836, 10.1371/journal.pone.0002836

J Tap, 2009, Towards the human intestinal microbiota phylogenetic core., Environ Microbiol, 11, 2574, 10.1111/j.1462-2920.2009.01982.x

A Salonen, 2010, Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: Effective recovery of bacterial and archaeal DNA using mechanical cell lysis., J Microbiol Methods

PJ Sansonetti, 2007, Debugging how bacteria manipulate the immune response., Immunity, 26, 149, 10.1016/j.immuni.2007.02.004

JL Round, 2009, The gut microbiota shapes intestinal immune responses during health and disease., Nat Rev Immunol, 9, 313, 10.1038/nri2515

T Vanhoutte, 2004, Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group-specific 16S rRNA gene primers., FEMS Microbiol Ecol, 48, 437, 10.1016/j.femsec.2004.03.001

TD Leser, 2009, Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host., Environ Microbiol, 11, 2194, 10.1111/j.1462-2920.2009.01941.x

H Hayashi, 2003, Molecular analysis of fecal microbiota in elderly individuals using 16S rDNA library and T-RFLP., Microbiol Immunol, 47, 557, 10.1111/j.1348-0421.2003.tb03418.x

J Zwielehner, 2009, Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of <italic>Bacteroides</italic>, bifidobacteria and <italic>Clostridium</italic> cluster IV in institutionalized elderly., Experimen Gerontol, 44, 440, 10.1016/j.exger.2009.04.002

A Barcenilla, 2000, Phylogenetic relationships of butyrate-producing bacteria from human gut., Appl Environ Microbiol, 66, 1654, 10.1128/AEM.66.4.1654-1661.2000

SE Pryde, 2002, The microbiology of butyrate formation in the human colon., FEMS Microbiol Lett, 217, 133, 10.1111/j.1574-6968.2002.tb11467.x

P Louis, 2009, Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine., FEMS Microbiol Lett, 294, 1, 10.1111/j.1574-6968.2009.01514.x

R Thibault, 2009, Butyrate utilization by the colonic mucosa in inflammatory bowel diseases: a transport deficiency., Inflamm Bowel Dis, 16, 684, 10.1002/ibd.21108

H Sokol, 2008, <italic>Faecalibacterium prausnitzii</italic> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn&apos;s disease patients., Proc Natl Acad Sci USA, 105, 16731, 10.1073/pnas.0804812105

H Sokol, 2009, Low counts of <italic>Faecalibacterium prausnitzii</italic> in colitis microbiota., Inflamm bowel Dis, 15, 1183, 10.1002/ibd.20903

T Pédron, 2008, Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois., Cell Host & Microbes, 3, 344, 10.1016/j.chom.2008.05.010

PJ Sansonetti, 2009, Learning tolerance while fighting ignorance., Cell, 138, 416, 10.1016/j.cell.2009.07.024

MC Collado, 2007, Intestinal integrity and <italic>Akkermansia muciniphila</italic>, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly., Appl Environ Microbiol, 73, 7767, 10.1128/AEM.01477-07

A Swidsinski, 2009, Acute appendicitis is characterized by local invasion with <italic>Fusobacterium nucleatum/necrophorum</italic>., Gut

FF Fagnoni, 2000, Shortage of circulating naive CD8<sup>+</sup> T cells provides new insights on immunodeficiency in aging., Blood, 95, 2860, 10.1182/blood.V95.9.2860.009k35_2860_2868

F Zanni, 2003, Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8<sup>+</sup> T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence., Exp Gerontol, 38, 891, 10.1016/S0531-5565(03)00160-8

S Alberti, 2006, Age dependent modifications of type 1 and type 2 cytokines within virgin and memory CD4<sup>+</sup> T cells in human., Mech Ageing Dev, 127, 560, 10.1016/j.mad.2006.01.014

M Nasi, 2006, Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life., Aging Cell, 5, 167, 10.1111/j.1474-9726.2006.00204.x

S Koch, 2008, Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people., Immun Ageing, 25, 5

C Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence., Ann N Y Acad Sci, 908, 244, 10.1111/j.1749-6632.2000.tb06651.x

G Baggio, 1998, Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors., FASEB J, 12, 433, 10.1096/fasebj.12.6.433

G Passeri, 2003, Low vitamin D status, high bone turnover, and bone fractures in centenarians., J Clin Endocrinol Metab, 88, 5109, 10.1210/jc.2003-030515

O Kanauchi, 2006, <italic>Eubacterium limosum</italic> ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity., World J Gastroenterol, 12, 1071, 10.3748/wjg.v12.i7.1071

H Hur, 2000, Biotransformation of the isoflavonoids biochanin A, formononetin, and glycitein by <italic>Eubacterium limosum</italic>., FEMS Microbiol Lett, 192, 21, 10.1111/j.1574-6968.2000.tb09353.x

S Possemiers, 2008, <italic>Eubacterium limosum</italic> activates isoxanthohumol from hops (<italic>Humulus lupulus L</italic>.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine., J Nutr, 138, 1310, 10.1093/jn/138.7.1310

H Adlercreutz, 2002, Phyto-oeastrogens and cancer., Lancet Oncol, 3, 364, 10.1016/S1470-2045(02)00777-5

JE Cohen, 2003, Human population: the next half century., Science, 302, 1172, 10.1126/science.1088665

DJ Lane, 1991, 16S/23S Sequencing., 115

J Leps, 2003, Cambridge University Press: Multivariate analysis of ecological data using CANOCO.

EH Simpson, 1949, Measurements of diversity., Nature, 163, 688, 10.1038/163688a0

T Matsuki, 2004, Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces., Appl Environ Microbiol, 70, 7220, 10.1128/AEM.70.12.7220-7228.2004

P Kaufmann, 1997, Identification and quantification of <italic>Bifidobacterium</italic> species isolated from food with genus-specific 16S rRNA-targeted probes by colony hybridization and PCR., Appl Environ Microbiol, 63, 1268, 10.1128/AEM.63.4.1268-1273.1997

P Marteau, 2001, Comparative study of bacterial groups within the human cecal and fecal microbiota., Appl Environ Microbiol, 67, 4939, 10.1128/AEM.67.10.4939-4942.2001

T Rinttilä, 2004, Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR., J Appl Microbiol, 97, 1166, 10.1111/j.1365-2672.2004.02409.x

MJ Kullen, 2000, Use of the DNA sequence of variable regions of the 16S rRNA gene for rapid and accurate identification of bacteria in the <italic>Lactobacillus acidophilus</italic> complex., J Appl Microbiol, 89, 511, 10.1046/j.1365-2672.2000.01146.x

G Baker, 2003, Review and re-analysis of domain-specific 16S primers., J Microbiol Methods, 55, 541, 10.1016/j.mimet.2003.08.009

M Recasens, 2005, An inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance., J Clin Endocrinol Metab, 90, 112, 10.1210/jc.2004-0708

BB Duncan, 2003, Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study., Diabetes, 52, 1799, 10.2337/diabetes.52.7.1799