Irradiation of anatomically defined pelvic subsites and acute hematologic toxicity in anal cancer patients undergoing chemoradiation

Nigro, 1983, Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal, Cancer, 51, 1826, 10.1002/1097-0142(19830515)51:10<1826::AID-CNCR2820511012>3.0.CO;2-L Gunderson, 2012, Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: Survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin, J Clin Oncol, 30, 4344, 10.1200/JCO.2012.43.8085 James, 2013, Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): A randomised, phase 3, open-label, 2 × 2 factorial trial, Lancet Oncol, 14, 516, 10.1016/S1470-2045(13)70086-X Ajani, 2008, Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: A randomized controlled trial, JAMA, 299, 1914, 10.1001/jama.299.16.1914 Ben-Josef, 2010, Impact of overall treatment time on survival and local control in patients with anal cancer: A pooled data analysis of Radiation Therapy Oncology Group trials 87-04 and 98-11, J Clin Oncol, 28, 5061, 10.1200/JCO.2010.29.1351 Bazan, 2013, Impact of chemotherapy on normal tissue complication probability models of acute hematologic toxicity in patients receiving pelvic intensity modulated radiation therapy, Int J Radiat Oncol Biol Phys, 87, 983, 10.1016/j.ijrobp.2013.09.017 Mell, 2008, Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy, Int J Radiat Oncol Biol Phys, 70, 1431, 10.1016/j.ijrobp.2007.08.074 Liang, 2010, Impact of bone marrow radiation dose on acute hematologic toxicity in cervical cancer: Principal component analysis on high dimensional data, Int J Radiat Oncol Biol Phys, 78, 912, 10.1016/j.ijrobp.2009.11.062 Wan, 2015, Can dosimetric parameters predict acute hematologic toxicity in rectal cancer patients treated with intensity-modulated pelvic radiotherapy?, Radiat Oncol Lond Engl, 10, 162, 10.1186/s13014-015-0454-0 Mauch, 1995, Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy, Int J Radiat Oncol Biol Phys, 31, 1319, 10.1016/0360-3016(94)00430-S Bazan, 2011, Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal, Cancer, 117, 3342, 10.1002/cncr.25901 Liang, 2013, Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies, Int J Radiat Oncol Biol Phys, 85, 406, 10.1016/j.ijrobp.2012.04.044 Rattan, 2016, Comparison of bone marrow sparing intensity modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT) in carcinoma of anal canal: A prospective study, Ann Transl Med, 4, 70 Hui, 2014, Association between bone marrow dosimetric parameters and acute hematologic toxicity in cervical cancer patients undergoing concurrent chemoradiotherapy: Comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy, Int J Gynecol Cancer, 24, 1648, 10.1097/IGC.0000000000000292 Rose, 2012, Correlation between radiation dose to 18F-FDG-PET defined active bone marrow subregions and acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy, Int J Radiat Oncol Biol Phys, 83, 1185, 10.1016/j.ijrobp.2011.09.048 Rose, 2016, Irradiation of FDG-PET-defined active bone marrow subregions and acute hematologic toxicity in anal cancer patients undergoing chemoradiation, Int J Radiat Oncol Biol Phys, 94, 747, 10.1016/j.ijrobp.2015.12.006 Cheng, 2014, Lumbosacral spine and marrow cavity modeling of acute hematologic toxicity in patients treated with intensity modulated radiation therapy for squamous cell carcinoma of the anal canal, Pract Radiat Oncol, 4, 198, 10.1016/j.prro.2013.07.011 Franco, 2017, Dosimetric predictors of acute hematologic toxicity during concurrent intensity-modulated radiotherapy and chemotherapy for anal cancer, Clin Transl Oncol, 19, 67, 10.1007/s12094-016-1504-2 Kachnic, 2013, RTOG 0529: A phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal, Int J Radiat Oncol Biol Phys, 86, 27, 10.1016/j.ijrobp.2012.09.023 Myerson, 2009, Elective clinical target volumes for conformal therapy in anorectal cancer: A radiation therapy oncology group consensus panel contouring atlas, Int J Radiat Oncol Biol Phys, 74, 824, 10.1016/j.ijrobp.2008.08.070 Radiation Therapy Oncology Group Miften, 2004, Incorporation of functional imaging data in the evaluation of dose distributions using the generalized concept of equivalent uniform dose, Phys Med Biol, 49, 1711, 10.1088/0031-9155/49/9/009 Dupont, 1998, Power and sample size calculations for studies involving linear regression, Control Clin Trials, 19, 589, 10.1016/S0197-2456(98)00037-3 Lee, 2017, Hematologic nadirs during chemoradiation for anal cancer: Temporal characterization and dosimetric predictors, Int J Radiat Oncol Biol Phys, 97, 306, 10.1016/j.ijrobp.2016.10.010 Franco, 2016, Dose to specific subregions of pelvic bone marrow defined with FDG-PET as a predictor of hematologic nadirs during concomitant chemoradiation in anal cancer patients, Med Oncol, 33, 72, 10.1007/s12032-016-0789-x Lee, 2016, Hematologic toxicity during anal cancer treatment: The importance of pelvic bone marrow volume and limiting radiation dose to a critical marrow volume, Int J Radiat Oncol Biol Phys, 96 Ojerholm, 2015, Pencil-beam scanning proton therapy for anal cancer: A dosimetric comparison with intensity-modulated radiotherapy, Acta Oncol, 54, 1209, 10.3109/0284186X.2014.1002570 Anand, 2015, Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer, Radiother Oncol J, 117, 505, 10.1016/j.radonc.2015.10.027