Reduced motor cortex plasticity following inhibitory rTMS in older adults

Adams, 1987, Comparison of synaptic changes in the precentral and postcentral cerebral cortex of aging humans: a quantitative ultrastructural study, Neurobiol Aging, 8, 203, 10.1016/0197-4580(87)90003-0 Adams, 1987, Plasticity of the synaptic contact zone following loss of synapses in the cerebral cortex of aging humans, Brain Res, 424, 343, 10.1016/0006-8993(87)91479-X Arai, 2007, Differences in after-effect between monophasic and biphasic high-frequency rTMS of the human motor cortex, Clin Neurophysiol, 118, 2227, 10.1016/j.clinph.2007.07.006 Berardelli, 1998, Facilitation of muscle evoked responses after repetitive cortical stimulation in man, Exp Brain Res, 122, 79, 10.1007/s002210050493 Brasil-Neto, 1992, Rapid reversible modulation of human motor outputs after transient deafferentation of the forearm: a study with transcranial magnetic stimulation, Neurology, 42, 1302, 10.1212/WNL.42.7.1302 Calabresi, 1992, Long-term synaptic depression in the striatum: physiological and pharmacological characterization, J Neurosci, 12, 4224, 10.1523/JNEUROSCI.12-11-04224.1992 Cohen, 1991, Motor reorganization after upper limb amputation in man. A study with focal magnetic stimulation, Brain, 114, 615, 10.1093/brain/114.1.615 Dennis, 2003, Age deficits in learning sequences of spoken words, J Gerontol B Psychol Sci Soc Sci, 58, P224, 10.1093/geronb/58.4.P224 Di Lazzaro, 2008, The physiological basis of the effects of intermittent theta burst stimulation of the human motor cortex, J Physiol, 586, 3871, 10.1113/jphysiol.2008.152736 Di Lazzaro, 1998, Effects of voluntary contraction on descending volleys evoked by transcranial stimulation in conscious humans, J Physiol, 508, 625, 10.1111/j.1469-7793.1998.625bq.x Doherty, 1993, Effects of ageing on the motor unit: a brief review, Can J Appl Physiol, 18, 331, 10.1139/h93-029 Eisen, 1996, Cortical projections to spinal motoneurons: changes with aging and amyotrophic lateral sclerosis, Neurology, 46, 1396, 10.1212/WNL.46.5.1396 Fitzgerald, 2006, A randomized, controlled trial of sequential bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression, Am J Psychiatry, 163, 88, 10.1176/appi.ajp.163.1.88 Fitzgerald, 2006, A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition, Clin Neurophysiol, 117, 2584, 10.1016/j.clinph.2006.06.712 Floel, 2005, Dopaminergic influences on formation of a motor memory, Ann Neurol, 58, 121, 10.1002/ana.20536 Ghilardi, 2003, The differential effect of PD and normal aging on early explicit sequence learning, Neurology, 60, 1313, 10.1212/01.WNL.0000059545.69089.EE Good, 2001, A voxel-based morphometric study of ageing in 465 normal adult human brains, Neuroimage, 14, 21, 10.1006/nimg.2001.0786 Grafton, 1992, Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET, J Neurosci, 12, 2542, 10.1523/JNEUROSCI.12-07-02542.1992 Gu, 2002, Neuromodulatory transmitter systems in the cortex and their role in cortical plasticity, Neuroscience, 111, 815, 10.1016/S0306-4522(02)00026-X Harrington, 1992, Skill learning in the elderly: diminished implicit and explicit memory for a motor sequence, Psychol Aging, 7, 425, 10.1037/0882-7974.7.3.425 Helmich, 2006, Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson’s disease, J Neurol Sci, 248, 84, 10.1016/j.jns.2006.05.009 Henderson, 1980, Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer, J Neurol Sci, 46, 113, 10.1016/0022-510X(80)90048-9 Hess, 1994, Long-term potentiation of horizontal connections provides a mechanism to reorganize cortical motor maps, J Neurophysiol, 71, 2543, 10.1152/jn.1994.71.6.2543 Hiscock, 2008, Informing dose-finding studies of repetitive transcranial magnetic stimulation to enhance motor function: a qualitative systematic review, Neurorehabil Neural Repair, 22, 228, 10.1177/1545968307307115 Huang, 2008, Effect of age, gender, menopausal status, and ovarian hormonal level on rTMS in treatment-resistant depression, Psychoneuroendocrinology, 33, 821, 10.1016/j.psyneuen.2008.03.006 Huang, 2005, Theta burst stimulation of the human motor cortex, Neuron, 45, 201, 10.1016/j.neuron.2004.12.033 Iyer, 2003, Priming stimulation enhances the depressant effect of low-frequency repetitive transcranial magnetic stimulation, J Neurosci, 23, 10867, 10.1523/JNEUROSCI.23-34-10867.2003 Jankelowitz, 2007, Changes in measures of motor axon excitability with age, Clin Neurophysiol, 118, 1397, 10.1016/j.clinph.2007.02.025 Keel, 2000, A safety screening questionnaire for transcranial magnetic stimulation, Clin Neurophysiol, 112, 720, 10.1016/S1388-2457(00)00518-6 Kossev, 2002, Increased intracortical inhibition in middle-aged humans; a study using paired-pulse transcranial magnetic stimulation, Neurosci Lett, 333, 83, 10.1016/S0304-3940(02)00986-2 Kozel, 2000, How coil-cortex distance relates to age, motor threshold, and antidepressant response to repetitive transcranial magnetic stimulation, J Neuropsychiatry Clin Neurosci, 12, 376, 10.1176/jnp.12.3.376 Massey, 2007, Long-term depression: multiple forms and implications for brain function, Trends Neurosci, 30, 176, 10.1016/j.tins.2007.02.005 Muellbacher, 2001, Role of the human motor cortex in rapid motor learning, Exp Brain Res, 136, 431, 10.1007/s002210000614 Muller-Dahlhaus, 2008, Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation, Exp Brain Res, 187, 467, 10.1007/s00221-008-1319-7 Oldfield, 1971, The assessment and analysis of handedness: the Edinburgh inventory, Neuropsychologia, 9, 97, 10.1016/0028-3932(71)90067-4 Otani, 1998, Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex, Neuroscience, 85, 669, 10.1016/S0306-4522(97)00677-5 Pascual-Leone, 1998, Study and modulation of human cortical excitability with transcranial magnetic stimulation, J Clin Neurophysiol, 15, 333, 10.1097/00004691-199807000-00005 Peinemann, 2001, Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex, Neurosci Lett, 313, 33, 10.1016/S0304-3940(01)02239-X Pitcher, 2003, Age and sex differences in human motor cortex input–output characteristics, J Physiol, 546, 605, 10.1113/jphysiol.2002.029454 Purnell, 2004, Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women, J Clin Endocrinol Metab, 89, 281, 10.1210/jc.2003-030440 Ridding, 1995, Reorganisation in human motor cortex, Can J Physiol Pharmacol, 73, 218, 10.1139/y95-032 Ridding, 2007, Is there a future for therapeutic use of transcranial magnetic stimulation?, Nat Rev Neurosci, 8, 559, 10.1038/nrn2169 Robinson, 1975, Changes in monoamine oxidase and monoamines with human development and aging, Fed Proc, 34, 103 Rogasch, 2009, Corticomotor plasticity and learning of a ballistic thumb training task are diminished in older adults, J Appl Physiol, 107, 1874, 10.1152/japplphysiol.00443.2009 Rowe, 2006, Aging is associated with contrasting changes in local and distant cortical connectivity in the human motor system, Neuroimage, 32, 747, 10.1016/j.neuroimage.2006.03.061 Sale, 2007, Factors influencing the magnitude and reproducibility of corticomotor excitability changes induced by paired associative stimulation, Exp Brain Res, 181, 615, 10.1007/s00221-007-0960-x Sale, 2008, Cortisol inhibits neuroplasticity induction in human motor cortex, J Neurosci, 28, 8285, 10.1523/JNEUROSCI.1963-08.2008 Sale, 2005, Age-related differences in corticospinal control during functional isometric contractions in left and right hands, J Appl Physiol, 99, 1483, 10.1152/japplphysiol.00371.2005 Sanes, 2000, Plasticity and primary motor cortex, Annu Rev Neurosci, 23, 393, 10.1146/annurev.neuro.23.1.393 Santiago-Rodriguez, 2008, Repetitive transcranial magnetic stimulation decreases the number of seizures in patients with focal neocortical epilepsy, Seizure, 17, 677, 10.1016/j.seizure.2008.04.005 Sawaki, 2003, Age-dependent changes in the ability to encode a novel elementary motor memory, Ann Neurol, 53, 521, 10.1002/ana.10529 Siebner, 2003, Transcranial magnetic stimulation: new insights into representational cortical plasticity, Exp Brain Res, 148, 1, 10.1007/s00221-002-1234-2 Stefan, 2002, Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation, J Physiol, 543, 699, 10.1113/jphysiol.2002.023317 Stefan, 2006, Temporary occlusion of associative motor cortical plasticity by prior dynamic motor training, Cereb Cortex, 16, 376, 10.1093/cercor/bhi116 Su, 2005, Add-on rTMS for medication-resistant depression: a randomized, double-blind, sham-controlled trial in Chinese patients, J Clin Psychiatry, 66, 930, 10.4088/JCP.v66n0718 Swayne, 2008, Stages of motor output reorganization after hemispheric stroke suggested by longitudinal studies of cortical physiology, Cereb Cortex, 18, 1909, 10.1093/cercor/bhm218 Takeuchi, 2008, Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranial magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke, J Rehabil Med, 40, 298, 10.2340/16501977-0181 Tecchio, 2008, Age dependence of primary motor cortex plasticity induced by paired associative stimulation, Clin Neurophysiol, 119, 675, 10.1016/j.clinph.2007.10.023 Todd, 2006, Low-intensity repetitive transcranial magnetic stimulation decreases motor cortical excitability in humans, J Appl Physiol, 101, 500, 10.1152/japplphysiol.01399.2005 Todd, 2009, Voluntary movement and repetitive transcranial magnetic stimulation over human motor cortex, J Appl Physiol, 106, 1593, 10.1152/japplphysiol.91364.2008 Wassermann, 2002, Variation in the response to transcranial magnetic brain stimulation in the general population, Clin Neurophysiol, 113, 1165, 10.1016/S1388-2457(02)00144-X Wassermann, 1996, Use and safety of a new repetitive transcranial magnetic stimulator, Electroencephalogr Clin Neurophysiol, 101, 412, 10.1016/0924-980X(96)96004-X Zahr, 2008, Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy, Cereb Cortex, 18, 2241, 10.1093/cercor/bhm250 Ziemann, 2004, TMS and drugs, Clin Neurophysiol, 115, 1717, 10.1016/j.clinph.2004.03.006 Ziemann, 2004, Learning modifies subsequent induction of long-term potentiation-like and long-term depression-like plasticity in human motor cortex, J Neurosci, 24, 1666, 10.1523/JNEUROSCI.5016-03.2004 Ziemann, 2006, Pharmacological modulation of plasticity in the human motor cortex, Neurorehabil Neural Repair, 20, 243, 10.1177/1545968306287154 Ziemann, 2001, Modulation of practice-dependent plasticity in human motor cortex, Brain, 124, 1171, 10.1093/brain/124.6.1171