Acute-on-chronic liver failure in patients with alcohol-related liver disease

Journal of Hepatology - Tập 70 - Trang 319-327 - 2019
Thierry Gustot1,2,3,4,5, Rajiv Jalan5,6
1Dept. Gastroenterology and Hepato-Pancreatology, C.U.B. Erasme Hospital, Brussels, Belgium
2Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium
3Inserm Unité 1149, Centre de Recherche sur l’inflammation (CRI), Paris, France
4UMR S_1149, Université Paris Diderot, Paris, France
5The EASL-CLIF Consortium, European Foundation-CLIF, Barcelona, Spain
6Liver Failure Group, Insitute for Liver and Digestive Health, University College London, London, UK

Tài liệu tham khảo

Jalan, 2014, Toward an improved definition of acute-on-chronic liver failure, Gastroenterology, 147, 4, 10.1053/j.gastro.2014.05.005 Moreau, 2013, Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis, Gastroenterology, 144, 1426, 10.1053/j.gastro.2013.02.042 Bajaj, 2018, Acute-on-chronic liver failure: getting ready for prime time?, Hepatol Baltim Md, 68, 1621, 10.1002/hep.30056 Jalan, 2012, Role of predisposition, injury, response and organ failure in the prognosis of patients with acute-on-chronic liver failure: a prospective cohort study, Crit Care Lond Engl, 16, R227, 10.1186/cc11882 Choudhury, 2017, Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison of APASL ACLF research consortium (AARC) and CLIF-SOFA models, Hepatol Int, 11, 461, 10.1007/s12072-017-9816-z Michelena, 2015, Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis, Hepatol Baltim Md, 62, 762, 10.1002/hep.27779 Sersté, 2018, The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis, J Hepatol, 69, 318, 10.1016/j.jhep.2018.02.022 Katoonizadeh, 2010, Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study, Gut, 59, 1561, 10.1136/gut.2009.189639 Adebayo, 2015, Mechanism of cell death in acute-on-chronic liver failure: a clinico-pathologic-biomarker study, Liver Int Off J Int Assoc Study Liver, 35, 2564 Macdonald, 2018, Cell death markers in patients with cirrhosis and acute decompensation, Hepatol Baltim Md, 67, 989, 10.1002/hep.29581 Gustot, 2017, Sepsis in alcohol-related liver disease, J Hepatol, 67, 1031, 10.1016/j.jhep.2017.06.013 O’Leary, 2018, NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis, Hepatol Baltim Md, 10.1002/hep.29773 Shi, 2015, Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults, Hepatol Baltim Md, 62, 232, 10.1002/hep.27795 Jalan, 2014, Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure, J Hepatol, 61, 1038, 10.1016/j.jhep.2014.06.012 Cai, 2017, A nomogram for predicting prognostic value of inflammatory response biomarkers in decompensated cirrhotic patients without acute-on-chronic liver failure, Aliment Pharmacol Ther, 45, 1413, 10.1111/apt.14046 Forrest, 2017, Letter: there’s something about the Neutrophil-to-Lymphocyte ratio (NLR)…, Aliment Pharmacol Ther, 46, 474, 10.1111/apt.14183 Manz, 2014, Emergency granulopoiesis, Nat Rev Immunol, 14, 302, 10.1038/nri3660 Garg, 2012, Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure, Gastroenterology, 142, 10.1053/j.gastro.2011.11.027 Sen, 2004, Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study, Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc, 10, 1109 Mookerjee, 2003, Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis, Gut, 52, 1182, 10.1136/gut.52.8.1182 Clària, 2016, Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure, Hepatology, 64, 1249, 10.1002/hep.28740 Thursz, 2015, Prednisolone or pentoxifylline for alcoholic hepatitis, N Engl J Med, 372, 1619, 10.1056/NEJMoa1412278 Naveau, 2004, A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis, Hepatol Baltim Md, 39, 1390, 10.1002/hep.20206 Boetticher, 2008, A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis, Gastroenterology, 135, 1953, 10.1053/j.gastro.2008.08.057 Fernández, 2017, Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis, Gut Mookerjee, 2007, Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome, Hepatol Baltim Md, 46, 831, 10.1002/hep.21737 O’Brien, 2014, Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2, Nat Med, 20, 518, 10.1038/nm.3516 Bernsmeier, 2015, Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK, Gastroenterology, 148, 10.1053/j.gastro.2014.11.045 Markwick, 2015, Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis, Gastroenterology, 148, 10.1053/j.gastro.2014.11.041 Vergis, 2016, Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase, Gut Wasmuth, 2005, Patients with acute on chronic liver failure display “sepsis-like” immune paralysis, J Hepatol, 42, 195, 10.1016/j.jhep.2004.10.019 Boussif, 2016, Impaired intracellular signaling, myeloperoxidase release and bactericidal activity of neutrophils from patients with alcoholic cirrhosis, J Hepatol, 64, 1041, 10.1016/j.jhep.2015.12.005 Stadlbauer, 2009, Role of toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis, Am J Physiol Gastrointest Liver Physiol, 296, G15, 10.1152/ajpgi.90512.2008 Pasparakis, 2015, Necroptosis and its role in inflammation, Nature, 517, 311, 10.1038/nature14191 Kondo, 2018, Target for the prevention of progression of acute on chronic liver failure (ACLF), Hepatol Baltim Md, 289A Bergsbaken, 2009, Pyroptosis: host cell death and inflammation, Nat Rev Microbiol, 7, 99, 10.1038/nrmicro2070 Khanova, 2018, Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients, Hepatol Baltim Md, 67, 1737, 10.1002/hep.29645 Moreau, 2018, Effects of long-term norfloxacin therapy in patients with advanced cirrhosis, Gastroenterology, 155, 10.1053/j.gastro.2018.08.026 Bass, 2010, Rifaximin treatment in hepatic encephalopathy, N Engl J Med, 362, 1071, 10.1056/NEJMoa0907893 Olde Damink, 2003, The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis, Hepatol Baltim Md, 37, 1277, 10.1053/jhep.2003.50221 Shawcross, 2008, Ammonia impairs neutrophil phagocytic function in liver disease, Hepatol Baltim Md, 48, 1202, 10.1002/hep.22474 Dasarathy, 2016, Sarcopenia from mechanism to diagnosis and treatment in liver disease, J Hepatol, 65, 1232, 10.1016/j.jhep.2016.07.040 Jalan, 2016, Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension, J Hepatol, 64, 823, 10.1016/j.jhep.2015.11.019 Clària, 2018, Orchestration of Tryptophan-Kynurenine pathway, acute decompensation and acute-on-chronic liver failure in cirrhosis, Hepatol Baltim Md McPhail, 2016, Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis, J Hepatol, 64, 1058, 10.1016/j.jhep.2016.01.003 Gustot, 2015, Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis, Hepatology, 62, 243, 10.1002/hep.27849 Forrest, 2018, Prevalent acute-on-chronic liver failure and response to corticosteroids in alcoholic hepatitis, J Hepatol, 69, 1200, 10.1016/j.jhep.2018.06.019 Louvet, 2018, Corticosteroids reduce risk of death within 28 days for patients with severe alcoholic hepatitis, compared with pentoxifylline or placebo-a meta-analysis of individual data from controlled trials, Gastroenterology, 155, 10.1053/j.gastro.2018.05.011 Louvet, 2008, Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids, J Hepatol, 48, 465, 10.1016/j.jhep.2007.10.010 Laleman, 2006, Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure, Crit Care Lond Engl, 10, R108, 10.1186/cc4985 Jalan, 2003, Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis, J Hepatol, 38, 24, 10.1016/S0168-8278(02)00334-3 Bañares, 2013, Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF trial, Hepatol Baltim Md, 57, 1153, 10.1002/hep.26185 Kribben, 2012, Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure, Gastroenterology, 142, 10.1053/j.gastro.2011.12.056 Spahr, 2008, Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trial, Hepatol Baltim Md, 48, 221, 10.1002/hep.22317 Khanam, 2014, Altered frequencies of dendritic cells and IFN-gamma-secreting T cells with granulocyte colony-stimulating factor (G-CSF) therapy in acute-on- chronic liver failure, Liver Int Off J Int Assoc Study Liver, 34, 505 Singh, 2014, Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot study, Am J Gastroenterol, 109, 1417, 10.1038/ajg.2014.154 Singh, 2018, Efficacy of granulocyte colony-stimulating factor and N-acetylcysteine therapies in patients with severe alcoholic hepatitis, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, 16 Philips, 2017, Healthy donor fecal microbiota transplantation in steroid-ineligible severe alcoholic hepatitis: a pilot study, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, 15, 600 Philips, 2018, Only in the darkness can you see the stars: severe alcoholic hepatitis and higher grades of acute-on-chronic liver failure, J Hepatol Putignano, 2017, New concepts in acute-on-chronic liver failure: Implications for liver transplantation, Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc, 23, 234 Artru, 2017, Liver transplantation in the most severely ill cirrhotic patients: a multicenter study in acute-on-chronic liver failure grade 3, J Hepatol, 67, 708, 10.1016/j.jhep.2017.06.009 Thuluvath, 2018, Liver transplantation in patients with multiple organ failures: feasibility and outcomes, J Hepatol, 69, 1047, 10.1016/j.jhep.2018.07.007 Duan, 2013, Liver transplantation in acute-on-chronic liver failure patients with high model for end-stage liver disease (MELD) scores: a single center experience of 100 consecutive cases, J Surg Res, 183, 936, 10.1016/j.jss.2013.03.008 Bahirwani, 2011, Acute-on-chronic liver failure before liver transplantation: impact on posttransplant outcomes, Transplantation, 92, 952, 10.1097/TP.0b013e31822e6eda Levesque, 2017, Impact of acute-on-chronic liver failure on 90-day mortality following a first liver transplantation, Liver Int Off J Int Assoc Study Liver, 37, 684 Umgelter, 2011, Orthotopic liver transplantation in critically ill cirrhotic patients with multi-organ failure: a single-center experience, Transplant Proc, 43, 3762, 10.1016/j.transproceed.2011.08.110 Fernández, 2018, Liver transplantation in patients with ACLF and multiple organ failure: time for priority after initial stabilization, J Hepatol, 69, 1004, 10.1016/j.jhep.2018.09.002 Bajaj, 2014, Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures, Hepatol Baltim Md, 60, 250, 10.1002/hep.27077 Fernandez, 2007, Gastroenterology, 133, 818, 10.1053/j.gastro.2007.06.065