Aging and the immune system: An overview

Journal of Immunological Methods - Tập 463 - Trang 21-26 - 2018
Amir A. Sadighi Akha1
1Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, United States

Tài liệu tham khảo

Akbar, 2017, The convergence of senescence and nutrient sensing during lymphocyte ageing, Clin. Exp. Immunol., 187, 4, 10.1111/cei.12876 Akbar, 2016, Senescence of T lymphocytes: implications for enhancing human immunity, Trends Immunol., 37, 866, 10.1016/j.it.2016.09.002 Bodnar, 1998, Extension of life-span by introduction of telomerase into normal human cells, Science, 279, 349, 10.1126/science.279.5349.349 Brenchley, 2006, Microbial translocation is a cause of systemic immune activation in chronic HIV infection, Nat. Med., 12, 1365, 10.1038/nm1511 Burch, 2014, Advances in geroscience: impact on healthspan and chronic disease, J. Gerontol. A Biol. Sci. Med. Sci., 69, S1, 10.1093/gerona/glu041 Campisi, 2007, Cellular senescence: when bad things happen to good cells, Nat. Rev. Mol. Cell Biol., 8, 729, 10.1038/nrm2233 Carvalhal Marques, 2015, The roles of cellular and organismal aging in the development of late-onset maladies, Annu. Rev. Pathol., 10, 1, 10.1146/annurev-pathol-012414-040508 Chen, 2009, Vaccination in the elderly: an immunological perspective, Trends Immunol., 30, 351, 10.1016/j.it.2009.05.002 Clegg, 2013, Frailty in elderly people, Lancet, 381, 752, 10.1016/S0140-6736(12)62167-9 Collado, 2007, Cellular senescence in cancer and aging, Cell, 130, 223, 10.1016/j.cell.2007.07.003 Colvin, 2017, Aging and the immune response to organ transplantation, J. Clin. Invest., 127, 2523, 10.1172/JCI90601 Coppe, 2010, The senescence-associated secretory phenotype: the dark side of tumor suppression, Annu. Rev. Pathol., 5, 99, 10.1146/annurev-pathol-121808-102144 Daste, 2017, Immune checkpoint inhibitors and elderly people: a review, Eur. J. Cancer, 82, 155, 10.1016/j.ejca.2017.05.044 Deeks, 2011, HIV infection, inflammation, immunosenescence, and aging, Annu. Rev. Med., 62, 141, 10.1146/annurev-med-042909-093756 den Braber, 2012, Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans, Immunity, 36, 288, 10.1016/j.immuni.2012.02.006 Ferguson, 1995, Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors, J. Gerontol. A Biol. Sci. Med. Sci., 50, B378, 10.1093/gerona/50A.6.B378 Franceschi, 2014, Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases, J. Gerontol. A Biol. Sci. Med. Sci., 69, S4, 10.1093/gerona/glu057 Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N. Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x Franceschi, 2017, Immunobiography and the heterogeneity of immune responses in the elderly: a focus on inflammaging and trained immunity, Front. Immunol., 8, 982, 10.3389/fimmu.2017.00982 Frasca, 2004, Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase, J. Immunol., 172, 2155, 10.4049/jimmunol.172.4.2155 Frasca, 2007, Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA, J. Immunol., 179, 918, 10.4049/jimmunol.179.2.918 Frasca, 2008, Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells, J. Immunol., 180, 5283, 10.4049/jimmunol.180.8.5283 Frasca, 2010, Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans, Vaccine, 28, 8077, 10.1016/j.vaccine.2010.10.023 Frasca, 2011, Age effects on B cells and humoral immunity in humans, Ageing Res. Rev., 10, 330, 10.1016/j.arr.2010.08.004 Fulop, 2014, Cellular signaling in the aging immune system, Curr. Opin. Immunol., 29, 105, 10.1016/j.coi.2014.05.007 Garcia, 2005, Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells, Eur. J. Immunol., 35, 622, 10.1002/eji.200425538 Garcia, 2007, Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells, J. Immunol., 179, 6403, 10.4049/jimmunol.179.10.6403 Gibson, 2009, B-cell diversity decreases in old age and is correlated with poor health status, Aging Cell, 8, 18, 10.1111/j.1474-9726.2008.00443.x Goronzy, 2012, Immune aging and autoimmunity, Cell. Mol. Life Sci., 69, 1615, 10.1007/s00018-012-0970-0 Goronzy, 2013, Understanding immunosenescence to improve responses to vaccines, Nat. Immunol., 14, 428, 10.1038/ni.2588 Goronzy, 2015, Naive T cell maintenance and function in human aging, J. Immunol., 194, 4073, 10.4049/jimmunol.1500046 Gregor, 2011, Inflammatory mechanisms in obesity, Annu. Rev. Immunol., 29, 415, 10.1146/annurev-immunol-031210-101322 Hadrup, 2006, Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly, J. Immunol., 176, 2645, 10.4049/jimmunol.176.4.2645 Haines, 2009, Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function, J. Exp. Med., 206, 275, 10.1084/jem.20080996 Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 Hao, 2011, A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice, Blood, 118, 1294, 10.1182/blood-2011-01-330530 Hayflick, 1961, The serial cultivation of human diploid cell strains, Exp. Cell Res., 25, 585, 10.1016/0014-4827(61)90192-6 Heintz, 2014, You are what you host: microbiome modulation of the aging process, Cell, 156, 408, 10.1016/j.cell.2014.01.025 Hoos, 2016, Development of immuno-oncology drugs - from CTLA4 to PD1 to the next generations, Nat. Rev. Drug Discov., 15, 235, 10.1038/nrd.2015.35 Hurez, 2017, Considerations for successful cancer immunotherapy in aged hosts, Clin. Exp. Immunol., 187, 53, 10.1111/cei.12875 June, 2017, Is autoimmunity the Achilles' heel of cancer immunotherapy?, Nat. Med., 23, 540, 10.1038/nm.4321 Karnell, 2017, Role of CD11c(+) T-bet(+) B cells in human health and disease, Cell. Immunol., 321, 40, 10.1016/j.cellimm.2017.05.008 Kennedy, 2014, Geroscience: linking aging to chronic disease, Cell, 159, 709, 10.1016/j.cell.2014.10.039 Khurana, 2012, AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans, PLoS Pathog., 8, 10.1371/journal.ppat.1002920 Kyle, 2006, Prevalence of monoclonal gammopathy of undetermined significance, N. Engl. J. Med., 354, 1362, 10.1056/NEJMoa054494 La Cava, 2004, The weight of leptin in immunity, Nat. Rev. Immunol., 4, 371, 10.1038/nri1350 Lanna, 2014, The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells, Nat. Immunol., 15, 965, 10.1038/ni.2981 Li, 2012, Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity, Nat. Med., 18, 1518, 10.1038/nm.2963 Li, 2015, Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation, J. Immunol., 195, 865, 10.4049/jimmunol.1402389 Lopez-Otin, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039 McKenna, 2001, Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry, Blood, 98, 2498, 10.1182/blood.V98.8.2498 Meier, 2009, The intestinal epithelial barrier: does it become impaired with age?, Dig. Dis., 27, 240, 10.1159/000228556 Min, 2004, Reduction in the developmental potential of intrathymic T cell progenitors with age, J. Immunol., 173, 245, 10.4049/jimmunol.173.1.245 Naradikian, 2016, Age-associated B cells: key mediators of both protective and autoreactive humoral responses, Immunol. Rev., 269, 118, 10.1111/imr.12380 Netea, 2016, Trained immunity: A program of innate immune memory in health and disease, Science, 352, 10.1126/science.aaf1098 Nikolich-Zugich, 2012, The aging immune system: challenges for the 21st century, Semin. Immunol., 24, 301, 10.1016/j.smim.2012.09.001 Ohashi, 2010, Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype, J. Biol. Chem., 285, 6153, 10.1074/jbc.M109.088708 Palmer, 2013, The effect of age on thymic function, Front. Immunol., 4, 316, 10.3389/fimmu.2013.00316 Pang, 2011, Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age, Proc. Natl. Acad. Sci. U. S. A., 108, 20012, 10.1073/pnas.1116110108 Park, 2005, Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6, Diabetes Res. Clin. Pract., 69, 29, 10.1016/j.diabres.2004.11.007 Pinti, 2016, Aging of the immune system: Focus on inflammation and vaccination, Eur. J. Immunol., 46, 2286, 10.1002/eji.201546178 Pourgheysari, 2007, The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire, J. Virol., 81, 7759, 10.1128/JVI.01262-06 Prelog, 2009, Thymectomy in early childhood: significant alterations of the CD4(+)CD45RA(+)CD62L(+) T cell compartment in later life, Clin. Immunol., 130, 123, 10.1016/j.clim.2008.08.023 Puzianowska-Kuznicka, 2016, Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study, Immun. Ageing, 13, 21, 10.1186/s12979-016-0076-x Qi, 2014, Diversity and clonal selection in the human T-cell repertoire, Proc. Natl. Acad. Sci. U. S. A., 111, 13139, 10.1073/pnas.1409155111 Rossi, 2005, Cell intrinsic alterations underlie hematopoietic stem cell aging, Proc. Natl. Acad. Sci. U. S. A., 102, 9194, 10.1073/pnas.0503280102 Rubtsov, 2011, Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity, Blood, 118, 1305, 10.1182/blood-2011-01-331462 Sadighi Akha, 2005, Signal transduction in the aging immune system, Curr. Opin. Immunol., 17, 486, 10.1016/j.coi.2005.07.004 Sadighi Akha, 2006, Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old mice, Immunology, 119, 187, 10.1111/j.1365-2567.2006.02420.x Sansoni, 2014, New advances in CMV and immunosenescence, Exp. Gerontol., 55, 54, 10.1016/j.exger.2014.03.020 Sauce, 2011, Altered thymic activity in early life: how does it affect the immune system in young adults?, Curr. Opin. Immunol., 23, 543, 10.1016/j.coi.2011.05.001 Sauce, 2009, Evidence of premature immune aging in patients thymectomized during early childhood, J. Clin. Invest., 119, 3070, 10.1172/JCI39269 Siegrist, 2009, B-cell responses to vaccination at the extremes of age, Nat. Rev. Immunol., 9, 185, 10.1038/nri2508 Sierra, 2016, The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span, Cold Spring Harb. Perspect. Med., 6, a025163, 10.1101/cshperspect.a025163 Steinmann, 1986, Changes in the human thymus during aging, Curr. Top. Pathol., 75, 43, 10.1007/978-3-642-82480-7_2 United Nations Secretariat, E.S.A., 2017, World population prospects: the 2017 revision van den Broek, 2016, Neonatal thymectomy reveals differentiation and plasticity within human naive T cells, J. Clin. Invest., 126, 1126, 10.1172/JCI84997 van der Geest, 2015, Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans, Aging Cell, 14, 744, 10.1111/acel.12353 Youm, 2013, Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging, Cell Metab., 18, 519, 10.1016/j.cmet.2013.09.010 Yu, 2012, Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age, Proc. Natl. Acad. Sci. U. S. A., 109, E879, 10.1073/pnas.1109797109