Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

Cell Metabolism - Tập 15 Số 3 - Trang 361-371 - 2012
Houman Ashrafian1, Gábor Czibik1, Mohamed Bellahcene1, Dunja Aksentijević1, Anthony C. Smith2, Sarah J. Mitchell3,4, Michael S. Dodd5, Jennifer Kirwan6, Jonathan Byrne6, Christian Ludwig7, Henrik Isackson1, Arash Yavari1, Nicolaj B. Støttrup8, Hussain Contractor1, Thomas J. Cahill1, Natasha Sahgal9, Daniel R. Ball5, Rune Isak Dupont Birkler8, Iain P. Hargreaves10, Daniel A. Tennant7, John M. Land10, Craig A. Lygate1, Mogens Johannsen8, Rajesh Kharbanda1, Stefan Neubauer1, Charles Redwood1, Rafael de Cabo4, Ismayil Ahmet11, Mark I. Talan11, Ulrich L. Günther7, Alan J. Robinson2, Mark R. Viant6, Patrick J. Pollard10, Damian J. Tyler5, Hugh Watkins1,9
1Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 9DU, UK
2Medical Research Council, Mitochondrial Biology Unit, Cambridge CB2 0XY, UK
3Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Sydney NSW 2065, Australia
4Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224-6825, USA
5Cardiac Metabolism Research Group, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK
6School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
7School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK
8Department of Cardiology, Skejby Hospital, and Section for Toxicology and Drug Analysis, Department of Forensic Medicine, Aarhus University Hospital, Aarhus N 8200, Denmark
9Nuffield Department of Medicine, Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, UK
10Neurometabolic Unit, National Hospital of Neurology, London WC1N 3BG, UK
11Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224-6825, USA

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