IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Tài liệu tham khảo
Ancrile, 2007, Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis, Genes Dev., 21, 1714, 10.1101/gad.1549407
Atreya, 2000, Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo, Nat. Med., 6, 583, 10.1038/75068
Atreya, 2005, Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer, Clin. Rev. Allergy Immunol., 28, 187, 10.1385/CRIAI:28:3:187
Balkwill, 2005, Smoldering and polarized inflammation in the initiation and promotion of malignant disease, Cancer Cell, 7, 211, 10.1016/j.ccr.2005.02.013
Becker, 2004, TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling, Immunity, 21, 491, 10.1016/j.immuni.2004.07.020
Becker, 2005, IL-6 signaling promotes tumor growth in colorectal cancer, Cell Cycle, 4, 217, 10.4161/cc.4.2.1413
Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, 441, 235, 10.1038/nature04753
Bollrath, 2009, gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis, Cancer Cell, 15, 91, 10.1016/j.ccr.2009.01.002
Bromberg, 1999, Stat3 as an oncogene, Cell, 98, 295, 10.1016/S0092-8674(00)81959-5
Chan, 2004, Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis, J. Clin. Invest., 114, 720, 10.1172/JCI200421032
Coussens, 2002, Inflammation and cancer, Nature, 420, 860, 10.1038/nature01322
Dann, 2008, IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens, J. Immunol., 180, 6816, 10.4049/jimmunol.180.10.6816
Denning, 2007, Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses, Nat. Immunol., 8, 1086, 10.1038/ni1511
Dinarello, 1994, The interleukin-1 family: 10 years of discovery, FASEB J., 8, 1314, 10.1096/fasebj.8.15.8001745
Eaden, 2001, The risk of colorectal cancer in ulcerative colitis: a meta-analysis, Gut, 48, 526, 10.1136/gut.48.4.526
Ernst, 2008, STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice, J. Clin. Invest., 118, 1727
Fischer, 1997, I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion, Nat. Biotechnol., 15, 142, 10.1038/nbt0297-142
Fu, 2006, STAT3 in immune responses and inflammatory bowel diseases, Cell Res., 16, 214, 10.1038/sj.cr.7310029
Gao, 2007, Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas, J. Clin. Invest., 117, 3846, 10.1172/JCI31871
Garlanda, 2007, Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family, Cancer Res., 67, 6017, 10.1158/0008-5472.CAN-07-0560
Greten, 2005, NF-kB: linking inflammation and immunity to cancer development and progression, Nat. Rev. Immunol., 5, 749, 10.1038/nri1703
Greten, 2004, IKKb links inflammation and tumorigenesis in a mouse model of colitis-associated cancer, Cell, 118, 285, 10.1016/j.cell.2004.07.013
Grivennikov, 2008, Autocrine IL-6 signaling: a key event in tumorigenesis?, Cancer Cell, 13, 7, 10.1016/j.ccr.2007.12.020
Heikkila, 2008, Systematic review of the association between circulating interleukin-6 (IL-6) and cancer, Eur. J. Cancer, 44, 937, 10.1016/j.ejca.2008.02.047
Hodge, 2005, The role of IL-6 and STAT3 in inflammation and cancer, Eur. J. Cancer, 41, 2502, 10.1016/j.ejca.2005.08.016
Hussain, 2003, Radical causes of cancer, Nat. Rev. Cancer, 3, 276, 10.1038/nrc1046
Jenkins, 2005, Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling, Nat. Med., 11, 845, 10.1038/nm1282
Judd, 2004, Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130, Gastroenterology, 126, 196, 10.1053/j.gastro.2003.10.066
Karin, 2006, Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer, Cell, 124, 823, 10.1016/j.cell.2006.02.016
Kataoka, 2008, Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis, Carcinogenesis, 29, 1108, 10.1093/carcin/bgn061
Kishimoto, 2005, Interleukin-6: from basic science to medicine--40 years in immunology, Annu. Rev. Immunol., 23, 1, 10.1146/annurev.immunol.23.021704.115806
Klampfer, 2008, The role of signal transducers and activators of transcription in colon cancer, Front. Biosci., 13, 2888, 10.2741/2893
Kollias, 1999, On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease, Immunol. Rev., 169, 175, 10.1111/j.1600-065X.1999.tb01315.x
Kusaba, 2005, Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors, J. Clin. Pathol., 58, 833, 10.1136/jcp.2004.023416
Langholz, 1992, Colorectal cancer risk and mortality in patients with ulcerative colitis, Gastroenterology, 103, 1444, 10.1016/0016-5085(92)91163-X
Legrand-Poels, 2000, Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line, Biochem. J., 349, 765, 10.1042/bj3490765
Lin, 2007, A cytokine-mediated link between innate immunity, inflammation, and cancer, J. Clin. Invest., 117, 1175, 10.1172/JCI31537
Madamanchi, 2001, Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway, Arterioscler. Thromb. Vasc. Biol., 21, 321, 10.1161/01.ATV.21.3.321
Madison, 2002, Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine, J. Biol. Chem., 277, 33275, 10.1074/jbc.M204935200
Meira, 2008, DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice, J. Clin. Invest., 118, 2516
Mitsuyama, 2006, Interleukin-6 trans-signaling in inflammatory bowel disease, Cytokine Growth Factor Rev., 17, 451, 10.1016/j.cytogfr.2006.09.003
Neufert, 2007, An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression, Nat. Protoc., 2, 1998, 10.1038/nprot.2007.279
Parikh, 1997, IL-6 production in human intestinal epithelial cells following stimulation with IL-1 beta is associated with activation of the transcription factor NF-kappa B, J. Surg. Res., 69, 139, 10.1006/jsre.1997.5061
Peters, 1998, In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6, J. Immunol., 161, 3575, 10.4049/jimmunol.161.7.3575
Pikarsky, 2004, NF-kB functions as a tumour promoter in inflammation-associated cancer, Nature, 431, 461, 10.1038/nature02924
Popivanova, 2008, Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis, J. Clin. Invest., 118, 560
Poutahidis, 2007, Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma, Carcinogenesis, 28, 2614, 10.1093/carcin/bgm180
Radisky, 2004, Cancer. Respect thy neighbor!, Science, 303, 775, 10.1126/science.1094412
Rakoff-Nahoum, 2004, Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell, 118, 229, 10.1016/j.cell.2004.07.002
Rigby, 2007, Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon, Oncogene, 26, 4833, 10.1038/sj.onc.1210286
Rivat, 2004, Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes, Oncogene, 23, 3317, 10.1038/sj.onc.1207437
Romano, 1997, Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment, Immunity, 6, 315, 10.1016/S1074-7613(00)80334-9
Sakurai, 2008, Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis, Cancer Cell, 14, 156, 10.1016/j.ccr.2008.06.016
Sander, 2008, Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation, J. Immunol., 181, 3586, 10.4049/jimmunol.181.5.3586
Sansone, 2007, IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland, J. Clin. Invest., 117, 3988, 10.1172/JCI32533
Sriuranpong, 2003, Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system, Cancer Res., 63, 2948
Strober, 2007, The fundamental basis of inflammatory bowel disease, J. Clin. Invest., 117, 514, 10.1172/JCI30587
Sugimoto, 2008, IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis, J. Clin. Invest., 118, 534
Suzuki, 2001, CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation, J. Exp. Med., 193, 471, 10.1084/jem.193.4.471
Takeda, 1999, Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils, Immunity, 10, 39, 10.1016/S1074-7613(00)80005-9
Tebbutt, 2002, Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice, Nat. Med., 8, 1089, 10.1038/nm763
Veldhoen, 2006, TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity, 24, 179, 10.1016/j.immuni.2006.01.001
Wang, 2004, Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells, Nat. Med., 10, 48, 10.1038/nm976
Weir, 2003, Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control, J. Natl. Cancer Inst., 95, 1276, 10.1093/jnci/djg040
Xiao, 2007, The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis, Immunity, 26, 461, 10.1016/j.immuni.2007.02.012
Yamaoka, 2008, Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis, Proc. Natl. Acad. Sci. USA, 105, 11772, 10.1073/pnas.0801463105
Yu, 2007, Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment, Nat. Rev. Immunol., 7, 41, 10.1038/nri1995
Zheng, 2008, Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens, Nat. Med., 14, 282, 10.1038/nm1720