Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia

Anne Cathrine Staff1, Kristin Braekke2, Nina Kittelsen Harsem1, Torstein Lyberg3, Mette R. Holthe3
1Department of Obstetrics and Gynecology, Ulleval University Hospital, Kirkeveien 166, N-0450, Oslo, Norway
2The Department of Pediatrics, Ulleval University Hospital, Oslo, Norway
3Research Forum, Ulleval University Hospital, Oslo, Norway

Tài liệu tham khảo

Roberts, 2002, Recent insights into the pathogenesis of pre-eclampsia, Placenta, 23, 359, 10.1053/plac.2002.0819 Maynard, 2003, Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension and proteinuria in preeclampsia, J Clin Invest, 111, 649, 10.1172/JCI17189 Zhou, 2002, Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes and low platelets syndrome, Am J Pathol, 160, 1405, 10.1016/S0002-9440(10)62567-9 Vuorela, 2000, Amniotic fluid-soluble vascular endothelial growth factor receptor-1 in preeclampsia, Obstet Gynecol, 95, 353 Koga, 2003, Elevated serum soluble vascular endothelial growth factor receptor 1 (Svegfr-1) levels in women with preeclampsia, J Clin Endocrinol Metab, 88, 2348, 10.1210/jc.2002-021942 Tsatsaris, 2003, Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences, J Clin Endocrinol Metab, 88, 5555, 10.1210/jc.2003-030528 Sugimoto, 2003, Neutralization of circulating vascular endothelial growth factor (Vegf) by anti-Vegf antibodies and soluble Vegf receptor 1 (Sflt-1) induces proteinuria, J Biol Chem, 278, 12605, 10.1074/jbc.C300012200 Kabbinavar, 2003, Phase II randomized trial comparing bevacizumab plus fluorouracil (Fu)/leucovorin (Lv) with Fu/Lv alone in patients with metastatic colorectal cancer, J Clin Oncol, 21, 60, 10.1200/JCO.2003.10.066 Skjaerven, 2000, Birthweight by gestational age in Norway, Acta Obstet Gynecol Scand, 79, 440, 10.1034/j.1600-0412.2000.079006440.x Taylor, 2003, Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies, Am J Obstet Gynecol, 188, 177, 10.1067/mob.2003.111 Acog Practice Bulletin. Diagnosis And Management Of Preeclampsia And Eclampsia. Number 33, January 2002. American College Of Obstetricians And Gynecologists. Int J Gynaecol Obstet 2002; 77:67–75. Barleon, 2001, Soluble Vegfr-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors, Angiogenesis, 4, 143, 10.1023/A:1012245307884 Schlembach, 2003, Angiogenic factors in preeclampsia, J Soc Gyn Invest, 10, 316A Woods, 1998, Maternal and transplacental effects of cocaine, Ann N Y Acad Sci, 846, 1, 10.1111/j.1749-6632.1998.tb09722.x Levine, 2004, Circulating angiogenic factors and the risk of preeclampsia, N Engl J Med, 350, 672, 10.1056/NEJMoa031884 Jelkmann, 2001, Pitfalls in the measurement of circulating vascular endothelial growth factor, Clin Chem, 47, 617, 10.1093/clinchem/47.4.617 Baker, 1995, Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia, Obstet Gynecol, 86, 815, 10.1016/0029-7844(95)00259-T Sharkey, 1996, Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre-eclampsia, Eur J Clin Invest, 26, 1182, 10.1046/j.1365-2362.1996.830605.x Lyall, 1997, Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia, Br J Obstet Gynaecol, 104, 223, 10.1111/j.1471-0528.1997.tb11050.x Polliotti, 2003, Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe early-onset preeclampsia, Obstet Gynecol, 101, 1266 Reuvekamp, 1999, Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre-eclampsia, Br J Obstet Gynaecol, 106, 1019, 10.1111/j.1471-0528.1999.tb08107.x Helske, 2001, Expression of vascular endothelial growth factor receptors 12 and 3 in placentas from normal and complicated pregnancies, Mol Hum Reprod, 7, 205, 10.1093/molehr/7.2.205 Torry, 1998, Preeclampsia is associated with reduced serum levels of placenta growth factor, Am J Obstet Gynecol, 179, 1539, 10.1016/S0002-9378(98)70021-3 Thadhani, 2004, First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia, J Clin Endocrinol Metab, 89, 770, 10.1210/jc.2003-031244 Hirashima, 2003, Trophoblast expression of Fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta, Proc Natl Acad Sci U S A, 100, 15637, 10.1073/pnas.2635424100