Circulating complement factor H–related proteins 1 and 5 correlate with disease activity in IgA nephropathy

McGrogan, 2011, The incidence of primary glomerulonephritis worldwide: a systematic review of the literature, Nephrol Dial Transplant, 26, 414, 10.1093/ndt/gfq665 D'Amico, 2004, Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome, Semin Nephrol, 24, 179, 10.1016/j.semnephrol.2004.01.001 Jennette, 1988, The immunohistology of IgA nephropathy, Am J Kidney Dis, 12, 348, 10.1016/S0272-6386(88)80022-2 Magistroni, 2015, New developments in the genetics, pathogenesis, and therapy of IgA nephropathy, Kidney Int, 88, 974, 10.1038/ki.2015.252 Maillard, 2015, Current understanding of the role of complement in IgA nephropathy, J Am Soc Nephrol, 26, 1503, 10.1681/ASN.2014101000 Wyatt, 1987, Complement activation in IgA nephropathy, Kidney Int, 31, 1019, 10.1038/ki.1987.101 Zwirner, 1997, Activated complement C3: a potentially novel predictor of progressive IgA nephropathy, Kidney Int, 51, 1257, 10.1038/ki.1997.171 Kim, 2012, Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with IgA nephropathy, PLoS One, 7, e40495, 10.1371/journal.pone.0040495 Endo, 1998, Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy, Nephrol Dial Transplant, 13, 1984, 10.1093/ndt/13.8.1984 Roos, 2006, Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease, J Am Soc Nephrol, 17, 1724, 10.1681/ASN.2005090923 Hiemstra, 1987, Activation of the alternative pathway of complement by human serum IgA, Eur J Immunol, 17, 321, 10.1002/eji.1830170304 Stad, 1993, An acute model for IgA-mediated glomerular inflammation in rats induced by monoclonal polymeric rat IgA antibodies, Clin Exp Immunol, 92, 514, 10.1111/j.1365-2249.1993.tb03430.x Gharavi, 2011, Genome-wide association study identifies susceptibility loci for IgA nephropathy, Nat Genet, 43, 321, 10.1038/ng.787 Kiryluk, 2012, Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis, PLoS Genet, 8, e1002765, 10.1371/journal.pgen.1002765 Zhu, 2015, Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy, J Am Soc Nephrol, 26, 1195, 10.1681/ASN.2014010096 Xie, 2016, Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese, J Am Soc Nephrol, 27, 3187, 10.1681/ASN.2015111210 Tortajada, 2013, C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation, J Clin Invest, 123, 2434, 10.1172/JCI68280 Jozsi, 2015, Factor H-related proteins determine complement-activating surfaces, Trends Immunol, 36, 374, 10.1016/j.it.2015.04.008 Goicoechea de Jorge, 2013, Dimerization of complement factor H-related proteins modulates complement activation in vivo, Proc Natl Acad Sci U S A, 110, 4685, 10.1073/pnas.1219260110 Barbour, 2016, Update on C3 glomerulopathy, Nephrol Dial Transplant, 31, 717, 10.1093/ndt/gfu317 Moldoveanu, 2007, Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels, Kidney Int, 71, 1148, 10.1038/sj.ki.5002185 Berthoux, 2012, Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy, J Am Soc Nephrol, 23, 1579, 10.1681/ASN.2012010053 Yanagawa, 2014, A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases, PLoS One, 9, e98081, 10.1371/journal.pone.0098081 Barbour, 2013, Recent insights into C3 glomerulopathy, Nephrol Dial Transplant, 28, 1685, 10.1093/ndt/gfs430 Ansari, 2013, Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration, Hum Mol Genet, 22, 4857, 10.1093/hmg/ddt336 Gale, 2010, Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis, Lancet, 376, 794, 10.1016/S0140-6736(10)60670-8 Athanasiou, 2011, Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees, Clin J Am Soc Nephrol, 6, 1436, 10.2215/CJN.09541010 Cattran, 2009, The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification, Kidney Int, 76, 534, 10.1038/ki.2009.243 Malik, 2012, A hybrid CFHR3-1 gene causes familial C3 glomerulopathy, J Am Soc Nephrol, 23, 1155, 10.1681/ASN.2012020166 Chen, 2014, Complement factor H-related hybrid protein deregulates complement in dense deposit disease, J Clin Invest, 124, 145, 10.1172/JCI71866 Medjeral-Thomas, 2014, A novel CFHR5 fusion protein causes C3 glomerulopathy in a family without Cypriot ancestry, Kidney Int, 85, 933, 10.1038/ki.2013.348 Caesar, 2014, Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility, Elife, 3, 10.7554/eLife.04008 Buhlmann, 2016, FHR3 Blocks C3d-Mediated Coactivation of Human B Cells, J Immunol, 197, 620, 10.4049/jimmunol.1600053 Chakera, 2016, Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression, J Nephrol, 29, 367 Roberts, 2009, The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility, Kidney Int, 76, 546, 10.1038/ki.2009.168 Murphy, 2002, Factor H-related protein-5: a novel component of human glomerular immune deposits, Am J Kidney Dis, 39, 24, 10.1053/ajkd.2002.29873 2012, KDIGO clinical practice guideline for glomerulonephritis, Kidney Int Suppl, 2, 139 Rauen, 2015, Intensive Supportive Care plus Immunosuppression in IgA Nephropathy, N Engl J Med, 373, 2225, 10.1056/NEJMoa1415463 Andrew, 2001, Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women, Twin Res, 4, 464, 10.1375/twin.4.6.464 Levey, 2009, A new equation to estimate glomerular filtration rate, Ann Intern Med, 150, 604, 10.7326/0003-4819-150-9-200905050-00006 Lomax-Browne, 2017, IgA1 glycosylation is heritable in healthy twins, J Am Soc Nephrol, 28, 64, 10.1681/ASN.2016020184