ALK Mutation Status Before and After Alectinib Treatment in Locally Advanced or Metastatic ALK-Positive NSCLC: Pooled Analysis of Two Prospective Trials

Journal of Thoracic Oncology - Tập 15 - Trang 601-608 - 2020
Johannes Noé1, Alex Lovejoy2, Sai-Hong Ignatius Ou3, Stephanie J. Yaung2, Walter Bordogna1, Daniel M. Klass2, Craig A. Cummings4, Alice T. Shaw5
1F. Hoffmann-La Roche Ltd, Basel, Switzerland
2Roche Sequencing Solutions, Pleasanton, California
3University of California, Irvine School of Medicine, Orange, California
4Genentech, Inc., South San Francisco, California
5Massachusetts General Hospital, Boston, Massachusetts

Tài liệu tham khảo

Dearden, 2013, Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap), Ann Oncol, 24, 2371, 10.1093/annonc/mdt205 Barlesi, 2016, Updated efficacy and safety from the global phase II NP28673 study of alectinib in patients with previously treated ALK+ non–small-cell lung cancer (NSCLC), Ann Oncol, 27 Shaw, 2016, Alectinib in ALK-positive, crizotinib-resistant, non–small-cell lung cancer: a single-group, multicentre, phase 2 trial, Lancet Oncol, 17, 234, 10.1016/S1470-2045(15)00488-X Ou, 2020, Pooled overall survival and safety data from the pivotal phase II studies (NP28673 and NP28761) of alectinib in ALK-positive non–small-cell lung cancer, Lung Cancer, 139, 22, 10.1016/j.lungcan.2019.10.015 Peters, 2017, Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer, N Engl J Med, 377, 829, 10.1056/NEJMoa1704795 Camidge, 2019, Updated efficacy and safety data and impact of EML4-ALK fusion variant on the efficacy of alectinib in untreated ALK-positive advanced non–small cell lung cancer in the global phase III ALEX study, J Thorac Oncol, 14, 1233, 10.1016/j.jtho.2019.03.007 Gainor, 2016, Molecular mechanisms of resistance to first- and second-generation ALK inhibitors in ALK-rearranged lung cancer, Cancer Discov, 6, 1118, 10.1158/2159-8290.CD-16-0596 Dong, 2016, Elucidation of resistance mechanisms to second-generation ALK inhibitors alectinib and ceritinib in non–small cell lung cancer cells, Neoplasia, 18, 162, 10.1016/j.neo.2016.02.001 Bayliss, 2016, Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs, Cell Mol Life Sci, 73, 1209, 10.1007/s00018-015-2117-6 Lin, 2017, Targeting ALK: precision medicine takes on drug resistance, Cancer Discov, 7, 137, 10.1158/2159-8290.CD-16-1123 Ou, 2016, ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression, Lung Cancer, 91, 70, 10.1016/j.lungcan.2015.09.006 Newman, 2014, An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage, Nat Med, 20, 548, 10.1038/nm.3519 Newman, 2016, Integrated digital error suppression for improved detection of circulating tumor DNA, Nat Biotechnol, 34, 547, 10.1038/nbt.3520 Bamford, 2004, The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website, Br J Cancer, 91, 355, 10.1038/sj.bjc.6601894 Puig, 2016, Pooled mutation analysis for the NP28673 and NP28761 studies of alectinib in ALK+ non–small-cell lung cancer (NSCLC), J Clin Oncol, 34, abstr 9061, 10.1200/JCO.2016.34.15_suppl.9061 Noh, 2017, Molecular breakdown: a comprehensive view of anaplastic lymphoma kinase (ALK)-rearranged non–small cell lung cancer (NSCLC), J Pathol, 243, 307, 10.1002/path.4950 Katayama, 2014, Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib, Cancer Res, 20, 5686 Soo, 2011, Ethnic differences in survival outcome in patients with advanced stage non–small cell lung cancer: results of a meta-analysis of randomized controlled trials, J Thorac Oncol, 6, 1030, 10.1097/JTO.0b013e3182199c03 Gainor, 2015, Progression-free and overall survival in ALK-positive NSCLC patients treated with sequential crizotinib and ceritinib, Clin Cancer Res, 21, 2745, 10.1158/1078-0432.CCR-14-3009 Cao, 2018, The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non–small cell lung cancer patients, Onco Targets Ther, 11, 2637, 10.2147/OTT.S155995 Klega, 2018, Detection of somatic structural variants enables quantification and characterization of circulating tumor DNA in children with solid tumors, JCO Precis Oncol, 10.1200/PO.17.00285 Dawson, 2013, Analysis of circulating tumor DNA to monitor metastatic breast cancer, N Engl J Med, 368, 1199, 10.1056/NEJMoa1213261 Gadgeel, 2018, Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non–small-cell lung cancer: CNS efficacy results from the ALEX study, Ann Oncol, 29, 2214, 10.1093/annonc/mdy405 Chuang, 2019, Molecular modeling of ALK L1198F and/or G1202R mutations to determine differential crizotinib sensitivity, Sci Rep, 9, 11390, 10.1038/s41598-019-46825-1 Katayama, 2012, Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers, Sci Transl Med, 4, 120ra17, 10.1126/scitranslmed.3003316 Dagogo-Jack, 2019, Treatment with next-generation ALK inhibitors fuels plasma ALK mutation diversity, Clin Cancer Res, 25, 6662, 10.1158/1078-0432.CCR-19-1436 Shaw, 2019, ALK resistance mutations and efficacy of lorlatinib in advanced anaplastic lymphoma kinase-positive non–small-cell lung cancer, J Clin Oncol, 37, 1370, 10.1200/JCO.18.02236