Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Nature - Tập 402 Số 6762 - Trang 656-660 - 1999
Masayasu Kojima1, Hiroshi Hosoda1, Yukari Date1, Masamitsu Nakazato2, Hisayuki Matsuo1, Kenji Kangawa1
1Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, 565-8565, Japan
2Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889-1692, Japan

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bowers,C. Y. Growth hormone-releasing peptide (GHRP). Cell. Mol. Life Sci. 54, 1316–1329 (1998).

Smith,R. G. et al. Peptidomimetic regulation of growth hormone secretion. Endocrine Rev. 18, 621–645 (1997).

Smith,R. G. et al. A nonpeptidyl growth hormone secretagogue. Science 260, 1640–1643 (1993).

Akman,M. S., Girard,M., O'brien,L. F., Ho,A. K. & Chik,C. L. Mechanisms of action of a second generation growth hormone-releasing peptide (Ala-His-D-βNal-Ala-Trp-D-Phe-Lys-NH2) in rat anterior pituitary cells. Endocrinology 132, 1286–1291 (1993).

Cheng,K., Chan,W. W. S., Barreto,A., Convey,E. M. & Smith,R. G. The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 124, 2791–2798 (1989).

Howard,A. D. et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273, 974–977 (1996).

McKee,K. K. et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol. Endocrinol. 11, 415–423 (1997).

Civelli,O. Functional genomics: the search for novel neurotransmitters and neuropeptides. FEBS Lett. 430, 55–58 (1998).

Meunier,J. C. et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377, 532–535 (1995).

Reinscheid,R. K. et al. Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science 270, 792–794 (1995).

Sakurai,T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573–585 (1998).

Hinuma,S. et al. A prolactin-releasing peptide in the brain. Nature 393, 272–276 (1998).

Sudoh,T., Kangawa,K., Minamino,N. & Matsuo,H. A new natriuretic peptide in porcine brain. Nature 332, 78–81 (1988).

Kitamura,K. et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun. 192, 553–560 (1993).

Kozak,M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44, 283–292 (1986).

Heijne,V. G. A new method for predicting signal sequence cleavage sites. Nucleic Acids Res. 14. 4683–4690 (1986).

Nakayama,K. Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochem. J. 327, 625–635 (1997).

Kojima,M. et al. Cloning and characterization of a novel natriuretic peptide in frog (Rana catesbeiana). J. Biol. Chem. 269, 13136–13140 (1994).

Alonso,G. Effects of colchicine on the intraneuronal transport of secretory material prior to the axon: a morphofunctional study in hypothalamic neurosecretory neurons of the rat. Brain Res. 453, 191–203 (1988).

Guan,X. M. et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol. Brain Res. 48, 23–29 (1997).

Bisi,G. et al. Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans. J. Endocrinol. Invest. 22, 266–272 (1999).

Berghe,G. V. et al. Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness. J. Clin. Endocrinol. Metab. 84, 1311–1323 (1999).

Schroeder,K. S. & Neagle,B. D. FLIPR: a new instrument for accurate, high throughput optical screening. J. Biomol. Screening 1, 75–80 (1996).

Coward,P. et al. Controlling signaling with a specifically designed Gi-coupled receptor. Proc. Natl Acad. Sci. USA 95, 352–357 (1998).

Jonathan,N. B., Peleg,E. & Hoefer,M. T. Optimization of culture conditions for short-term pituitary cell culture. Methods Enzymol. 103, 249–257(1983).

Date,Y. et al. Orexin, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl Acad. Sci. USA 96, 748–753 (1999).

Date,Y. et al. Enterochromaffin-like cells, a cellular source of uroguanylin in rat stomach. Endocrinology 140, 2398–2404 (1999).