Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

Cell - Tập 146 Số 4 - Trang 633-644 - 2011
Piyush B. Gupta1, Christine F. Brainson2, Guozhi Jiang1, Sagi Shapira1, Kai Tao3, Charlotte Kuperwasser2,3, Eric S. Lander1,4,5
1Broad Institute, Cambridge, MA 02142, USA
2Department of Anatomy and Cellular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
3Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
4Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
5Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA

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