Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
Tóm tắt
Neoadjuvant therapy has become the standard of care for locally advanced mid‐low rectal cancer. Pathological complete response (pCR) can be achieved in 12%–38% of patients. Patients with pCR have the most favorable long‐term outcomes. Intensifying neoadjuvant therapy and extending the interval between termination of neoadjuvant treatment and surgery may increase the pCR rate. Growing evidence has raised the issue of whether local excision or observation rather than radical surgery is an alternative for patients who achieve a clinical complete response after neoadjuvant therapy. Herein, we highlight many of the advances and resultant controversies that are likely to dominate the research agenda for pCR of rectal cancer in the modern era.
Tài liệu tham khảo
10.1038/nrclinonc.2011.118
10.1245/s10434-011-1822-0
10.1093/annonc/mdr473
10.1093/annonc/mdw062
Cui J., 2015, Surgical management of patients with pathologic complete response in the primary tumor after neoadjuvant chemotherapy for rectal cancer, Chin J Oncol, 37, 456
10.1007/s00384-010-1082-7
10.1007/s00384-013-1821-7
10.1097/SLA.0000000000000368
10.1245/s10434-011-2209-y
10.1245/s10434-010-1506-1
10.1097/01.sla.0000141194.27992.32
10.1016/j.amjsurg.2013.01.042
10.1097/DCR.0b013e3182a25c4e
10.1200/JCO.2011.37.7176
Lee C.T., 2012, Computed tomography with histological correlation for evaluating tumor regression of rectal carcinoma after preoperative chemoradiation therapy, Hepatogastroenterology, 59, 2484
10.1016/j.surg.2010.03.025
10.1245/s10434-006-9269-4
10.1016/j.jamcollsurg.2008.01.002
10.1007/s00384-012-1419-5
10.1148/rg.263055086
10.1245/s10434-011-2210-5
10.1148/rg.303095085
10.1245/s10434-011-1607-5
10.1002/jmri.24835
10.1148/radiol.2272011747
10.1016/S1470-2045(10)70172-8
10.1056/NEJMoa040694
10.1002/bjs.5679
10.1200/JCO.2005.14.779
10.1200/JCO.2002.20.3.817
10.1056/NEJMoa010580
10.1016/S0140-6736(09)60484-0
10.1245/s10434-009-0735-7
10.1111/j.1463-1318.2011.02777.x
10.1016/S1072-7515(01)01159-0
10.1002/bjs.8700
10.1016/j.suronc.2007.10.008
10.1007/DCR.0b013e3181f5b64d
10.1111/j.1463-1318.2011.02761.x
10.1007/s11912-013-0297-5
10.1097/01.sla.0000161980.46459.96
10.1200/JCO.2009.22.0467
10.1016/S0959-8049(02)00377-5
10.1200/JCO.2005.08.144
10.1002/bjs.5506
10.1200/JCO.2012.42.9597
10.1056/NEJMoa060829
10.1200/JCO.2006.06.7629
10.1200/JCO.2010.34.4911
10.1016/S0360-3016(99)00486-1
10.1200/JCO.2013.51.7904
10.1016/j.ijrobp.2009.02.037
10.1016/j.ijrobp.2010.08.005
10.1016/S1470-2045(15)00004-2
10.1200/jco.2015.33.15_suppl.3500
10.1245/s10434-012-2327-1
10.1002/bjs.6377
10.1016/j.ijrobp.2015.10.061
10.4174/jkss.2013.84.6.338
10.1158/1078-0432.CCR-10-2273
10.1007/s00432-014-1712-5
10.1245/s10434-011-2044-1