Disorders of Orgasm and Ejaculation in Men

The Journal of Sexual Medicine - Tập 1 - Trang 58-65 - 2004
Chris G. McMahon1, Carmita Abdo2, Luca Incrocci3, Michael Perelman4, David Rowland5, Marcel Waldinger6, Zhong Cheng Xin7
1Australian Centre for Sexual Health, Sydney, Australia
2Psiquiatria, Sao Paulo, Brazil
3Department of Radiation Oncology, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
4New York USA
5Department of Psychiatry, Valparaiso University, Valparaiso, IN, USA
6Department of Psychiatry, Leyenburg Hospital, The Hague, The Netherlands
7Department of Urology, Peking University, Beijing, China

Tóm tắt

ABSTRACT Introduction Ejaculatory/orgasmic disorders, common male sexual dysfunctions, include premature ejaculation, inhibited ejaculation, anejaculation, retrograde ejaculation and anorgasmia. Aim To provide recommendations/guidelines concerning state-of-the-art knowledge for management of ejaculation/orgasmic disorders in men. Methods An International Consultation in collaboration with the major urology and sexual medicine associations assembled over 200 multidisciplinary experts from 60 countries into 17 committees. Committee members established specific objectives and scopes for various male and female sexual medicine topics. The recommendations concerning state-of-the-art knowledge in the respective sexual medicine topic represent the opinion of experts from five continents developed in a process over a 2-year period. Concerning the Disorders of Ejaculation/Orgasm in Men Committee, there were nine experts from six countries. Main Outcome Measure Expert opinion was based on grading of evidence-based medical literature, widespread internal committee discussion, public presentation and debate. Results Premature ejaculation management is dependent upon etiology. When secondary to ED, etiology-specific treatment is employed. When lifelong, initial pharmacotherapy (SSRI, topical anesthesia, PDE5 inhibitors) is appropriate. When associated with psychogenic/relationship factors, behavioral therapy is indicated. When acquired, pharmacotherapy and/or behavioral therapies are preferred. Retrograde ejaculation, diagnosed with spermatozoa and fructose in centrifuged post-ejaculatory voided urine, is managed by education, patient reassurance, pharmacotherapy or bladder neck reconstruction. Men with anejaculation or anorgasmia have a biologic failure of emission and/or psychogenic inhibited ejaculation. Men with age-related penile hypoanesthesia should be educated, reassured and be instructed in revised sexual techniques which maximize arousal. Conclusions More research is needed in understanding management of men with ejaculation/orgasmic dysfunction.

Tài liệu tham khảo

Lipshultz, 1981, Current concepts of the mechanisms of ejaculation. Normal and abnormal states, J Reprod Med, 26, 499 Ahlenius, 1981, Effects of a new type of 5-HT receptor agonist on male rat sexual behaviour, Pharmacol Biochem Behav, 15, 785, 10.1016/0091-3057(81)90023-X Waldinger, 1998, Premature ejaculation and serotonergic antidepressants-induced inhibited ejaculation: The involvement of the serotonergic system, Behav Brain Res, 92, 111, 10.1016/S0166-4328(97)00183-6 Olivier, 1998, Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour, Int Clin Psychopharmacol, 13(suppl 6), 9, 10.1097/00004850-199807006-00003 Waldinger, 2002, The neurobiological approach to early ejaculation, J Urol, 168, 2359, 10.1016/S0022-5347(05)64146-8 Waldinger, 2000, Selective serotonin reuptake inhibitors (SSRIs) and sexual side effects: Differences in delaying ejaculation, 117 Rowland, 2001, Defining early ejaculation for experimental and clinical investigations, Arch Sex Behav, 30, 235, 10.1023/A:1002714812709 Colpi, 1986, Evoked sacral potentials in subjects with true premature ejaculation, Andrologia, 18, 583, 10.1111/j.1439-0272.1986.tb01834.x Fanciullacci, 1988, Cortical evoked potentials in subjects with true premature ejaculation, Andrologia, 20, 326, 10.1111/j.1439-0272.1988.tb00695.x Kaplan, 1974, Group treatment of premature ejaculation, Arch Sex Behav, 3, 443, 10.1007/BF01541164 Masters, 1970, Human sexual inadequacy Spiess, 1984, Premature ejaculation: Investigation of factors in ejaculatory latency, J Abnorm Psychol, 93, 242, 10.1037/0021-843X.93.2.242 Strassberg, 1987, The psychophysiological nature of premature ejaculation, Arch Sex Behav, 16, 327, 10.1007/BF01542142 Kilmann, 1979, Treatments of premature ejaculation and psychogenic impotence: A critical review of the literature, Arch Sex Behav, 8, 81, 10.1007/BF01541215 Schover, 1982, Multiaxial problem-oriented system for sexual dysfunctions, Arch Gen Psychiat, 39, 614, 10.1001/archpsyc.1982.04290050080015 Grenier, 2001, Operationalizing early or premature ejaculation, J Sex Res, 38, 369, 10.1080/00224490109552108 Semans, 1956, Premature ejaculation: New approach, South Med J, 49 De Amicis, 1985, Clinical follow-up of couples treated for sexual dysfunction, Arch Sex Behav, 14, 467, 10.1007/BF01541749 Hawton, 1986, Long-term outcome of sex therapy, Behav Res Ther, 24, 665, 10.1016/0005-7967(86)90062-8 Althof, 1995, A double-blind crossover trial of clomipramine for premature ejaculation in 15 couples, J Clin Psychiatry, 56, 402 Waldinger, 1998, Effect of SSRI antidepressants on ejaculation: A double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline, J Clin Psychopharmacol, 18, 274, 10.1097/00004714-199808000-00004 McMahon, 1998, Treatment of early ejaculation with sertraline hydrochloride: A single-blind placebo controlled crossover study, J Urol, 159, 1935, 10.1016/S0022-5347(01)63201-4 Waldinger, 2001, Antidepressants and ejaculation: A double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone, J Clin Psychopharmacol, 21, 293, 10.1097/00004714-200106000-00007 Atmaca, 2002, The efficacy of citalopram in the treatment of early ejaculation: A placebo-controlled study, Int J Impot Res, 14, 502, 10.1038/sj.ijir.3900918 Waldinger, 2003, Towards evidenced based drug treatment research on early ejaculation: A critical evaluation of methodology, Int J Impot Res, 15, 309, 10.1038/sj.ijir.3901023 Strassberg, 1999, Clomipramine in the treatment of premature (early) ejaculation, J Sex Marital Ther, 25, 89, 10.1080/00926239908403982 McMahon, 1999, Treatment of early ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies, J Urol, 161, 1826, 10.1016/S0022-5347(05)68816-7 Kim, 1999, Short-term analysis of the effects of as needed use of sertraline at 5 PM for the treatment of early ejaculation, Urology, 54, 544, 10.1016/S0090-4295(99)00187-9 Berkovitch, 1995, Efficacy of prilocaine-lidocaine cream in the treatment of early ejaculation, J Urol, 154, 1360, 10.1016/S0022-5347(01)66861-7 Xin, 1997, Efficacy of a topical agent SS-cream in the treatment of early ejaculation: Preliminary clinical studies, Yonsei Med J, 38, 91, 10.3349/ymj.1997.38.2.91 Atikeler, 2002, Optimum usage of prilocaine-lidocaine cream in early ejaculation, Andrologia, 34, 356, 10.1046/j.1439-0272.2002.00511.x Abdel-Hamid, 2001, Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation, Int J Impot Res, 13, 41, 10.1038/sj.ijir.3900630 Salonia, 2002, A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation, J Urol, 168, 2486, 10.1016/S0022-5347(05)64174-2 Chen, 2003, Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation, Urology, 61, 197, 10.1016/S0090-4295(02)02075-7 American Psychiatry Association., 1994, Diagnostic and statistical manual of mental disorders Feldman, 1994, Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study, J Urol, 151, 54, 10.1016/S0022-5347(17)34871-1 Apfelbaum, 1989, Retarded ejaculation: A much- misunderstood syndrome, 168 Fenichel, 1945, The psychoanalytic theory of neurosis Friedman, 1973, Success phobia and retarded ejaculation, Am J Psychother, 27, 78, 10.1176/appi.psychotherapy.1973.27.1.78 Bancroft, 1999, Central Inhibition of sexual response in the male: A theoretical perspective, Neurosci Biobehav Rev, 23, 763, 10.1016/S0149-7634(99)00019-6 Perelman, 2001, Sildenafil, sex therapy, and retarded ejaculation, Journal of Sex Education & Therapy, 26, 13, 10.1080/01614576.2001.11074377 Perelman, 2003, Male orgasm, J Androl, 24 Bors, 1960, Neurological disturbances of sexual function with special reference to 529 patients with spinal cord injury, Urol Surv, 10, 191 Heiman, Empirically validated treatment for sexual dysfunction Delmonte, 1986, Meditation as a clinical intervention strategy: A brief review, International Journal of Psychosomatics, 33, 9 Fisher, 1986, Multimodal sex therapy with a blind man suffering from retarded ejaculation. Special issue: Social work practice in sexual problems, Journal of Social Work & Human Sexuality, 4, 95, 10.1300/J291v04n01_11 Kaplan, 1974, The new sex therapy Pettitt, 1982, Retarded ejaculation: Adjunctive treatment by hypnotically induced dreams in the context of sex therapy, Australian Journal of Clinical & Experimental Hypnosis, 10, 89 Zgourides, 1989, Retarded ejaculation: Overview and treatment implications, Journal of Psychology & Human Sexuality, 2, 139, 10.1300/J056v02n02_09 McCormick, 1990, Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients, J Clin Psychiatry, 51, 383 Ashton, 1997, Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: A large-scale retrospective study of 596 psychiatric outpatients, J Sex Marital Ther, 23, 165, 10.1080/00926239708403922 Aizenberg, 1995, Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors, Clin Neuropharmacol, 18, 320, 10.1097/00002826-199508000-00003 Balon, 1996, Intermittent amantadine for fluoxetine-induced anorgasmia, J Sex Marital Ther, 22, 290, 10.1080/00926239608404410 Shrivastava, 1995, Amantadine in the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors, J Clin Psychopharmacol, 15, 83, 10.1097/00004714-199502000-00014 Gitlin, 1995, Treatment of sexual side effects with dopaminergic agents, J Clin Psychiatry, 56, 124 Price, 1990, Treatment of clomipramine-induced anorgasmia with yohimbine: A case report, J Clin Psychiatry, 51, 32 Jacobsen, 1992, Fluoxetine-induced sexual dysfunction and an open trial of yohimbine, J Clin Psychiatry, 53, 119 Othmer, 1987, Effect of buspirone on sexual dysfunction in patients with generalized anxiety disorder, J Clin Psychiatry, 48, 201 Ashton, 1998, Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction, J Clin Psychiatry, 59, 112, 10.4088/JCP.v59n0304 Kara, 1996, The efficacy of fluoxetine in the treatment of early ejaculation: A double-blind placebo controlled study, J Urol, 156, 1631, 10.1016/S0022-5347(01)65467-3