Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

Abdala-Valencia, 2012, Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan, Am. J. Physiol. Lung Cell. Mol. Physiol., 303, L642, 10.1152/ajplung.00406.2011 Alemi, 2013, The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice, Gastroenterology, 144, 145, 10.1053/j.gastro.2012.09.055 Amireault, 2013, Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks, ACS Chem. Neurosci., 4, 64, 10.1021/cn300154j Appleby, 2014, The role of bile acids in functional GI disorders, J. Neurogastroenterol. Motil., 26, 1057, 10.1111/nmo.12370 Atarashi, 2013, Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota, Nature, 500, 232, 10.1038/nature12331 Baganz, 2013, A dialogue between the immune system and brain, spoken in the language of serotonin, ACS Chem. Neurosci., 4, 48, 10.1021/cn300186b Bernstein, 2011, Carcinogenicity of deoxycholate, a secondary bile acid, Arch. Toxicol., 85, 863, 10.1007/s00204-011-0648-7 Bonnin, 2011, A transient placental source of serotonin for the fetal forebrain, Nature, 472, 347, 10.1038/nature09972 Brigelius-Flohe, 1999, Vitamin E: function and metabolism, FASEB J., 13, 1145, 10.1096/fasebj.13.10.1145 Buffie, 2014, Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile, Nature, 517, 205, 10.1038/nature13828 Caporaso, 2010, QIIME allows analysis of high-throughput community sequencing data, Nat. Methods, 7, 335, 10.1038/nmeth.f.303 Caporaso, 2011, Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample, Proc. Natl. Acad. Sci. USA, 108, 4516, 10.1073/pnas.1000080107 Chabbi-Achengli, 2012, Decreased osteoclastogenesis in serotonin-deficient mice, Proc. Natl. Acad. Sci. USA, 109, 2567, 10.1073/pnas.1117792109 Clarke, 2013, The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner, Mol. Psychiatry, 18, 666, 10.1038/mp.2012.77 Collins, 1996, The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders, Gastroenterology, 111, 1683, 10.1016/S0016-5085(96)70034-3 Côté, 2003, Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function, Proc. Natl. Acad. Sci. USA, 100, 13525, 10.1073/pnas.2233056100 Côté, 2007, Maternal serotonin is crucial for murine embryonic development, Proc. Natl. Acad. Sci. USA, 104, 329, 10.1073/pnas.0606722104 de Crécy-Lagard, 2007, Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations, BMC Genomics, 8, 245, 10.1186/1471-2164-8-245 De Cuyper, 2013, A novel flow cytometry-based platelet aggregation assay, Blood, 121, e70, 10.1182/blood-2012-06-437723 Dewhirst, 1999, Phylogeny of the defined murine microbiota: altered Schaedler flora, Appl. Environ. Microbiol., 65, 3287, 10.1128/AEM.65.8.3287-3292.1999 Ducy, 2010, The two faces of serotonin in bone biology, J. Cell Biol., 191, 7, 10.1083/jcb.201006123 Edgar, 2013, UPARSE: highly accurate OTU sequences from microbial amplicon reads, Nat. Methods, 10, 996, 10.1038/nmeth.2604 Fukumoto, 2003, Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats, Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R1269, 10.1152/ajpregu.00442.2002 Gershon, 2007, The serotonin signaling system: from basic understanding to drug development for functional GI disorders, Gastroenterology, 132, 397, 10.1053/j.gastro.2006.11.002 Guindon, 2010, New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0, Syst. Biol., 59, 307, 10.1093/sysbio/syq010 Hirano, 1981, Isolation and characterization of thirteen intestinal microorganisms capable of 7 alpha-dehydroxylating bile acids, Appl. Environ. Microbiol., 41, 737, 10.1128/AEM.41.3.737-745.1981 Hoffman, 2012, Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity, Gastroenterology, 142, 844, 10.1053/j.gastro.2011.12.041 Islam, 2011, Bile acid is a host factor that regulates the composition of the cecal microbiota in rats, Gastroenterology, 141, 1773, 10.1053/j.gastro.2011.07.046 Kitahara, 2000, Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7alpha-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces, Int. J. Syst. Evol. Microbiol., 50, 971, 10.1099/00207713-50-3-971 Kitahara, 2001, Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7alpha-dehydroxylating activity, Int. J. Syst. Evol. Microbiol., 51, 39, 10.1099/00207713-51-1-39 Letunic, 2007, Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation, Bioinformatics, 23, 127, 10.1093/bioinformatics/btl529 Li, 2011, Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons, J. Neurosci., 31, 8998, 10.1523/JNEUROSCI.6684-10.2011 Liu, 2008, Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract, J. Pharmacol. Exp. Ther., 325, 47, 10.1124/jpet.107.132670 Liu, 2012, Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice, World J. Exp. Med., 2, 30, 10.5493/wjem.v2.i2.30 Lobato, 2010, alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression, Behav. Brain Res., 209, 249, 10.1016/j.bbr.2010.02.002 Ma, 2014, Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa, Proc. Natl. Acad. Sci. USA, 111, 9768, 10.1073/pnas.1404753111 Maes, 2000, Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness, J. Affect. Disord., 58, 241, 10.1016/S0165-0327(99)00121-4 Malik-Kale, 2008, Culture of Campylobacter jejuni with sodium deoxycholate induces virulence gene expression, J. Bacteriol., 190, 2286, 10.1128/JB.01736-07 Marcobal, 2012, Tyramine and phenylethylamine biosynthesis by food bacteria, Crit. Rev. Food Sci. Nutr., 52, 448, 10.1080/10408398.2010.500545 Markowitz, 2012, IMG: the Integrated Microbial Genomes database and comparative analysis system, Nucleic Acids Res., 40, D115, 10.1093/nar/gkr1044 Mawe, 2013, Serotonin signalling in the gut–functions, dysfunctions and therapeutic targets, Nat. Rev. Gastroenterol. Hepatol., 10, 473, 10.1038/nrgastro.2013.105 McVey Neufeld, 2013, The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse, Neurogastroenterol. Motil., 25, e183, 10.1111/nmo.12049 Mercado, 2013, A serotonin-induced N-glycan switch regulates platelet aggregation, Sci. Rep., 3, 2795, 10.1038/srep02795 Muller, 2014, Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility, Cell, 158, 300, 10.1016/j.cell.2014.04.050 Narushima, 2006, Deoxycholic acid formation in gnotobiotic mice associated with human intestinal bacteria, Lipids, 41, 835, 10.1007/s11745-006-5038-1 Nieswandt, 2004, Flow-cytometric analysis of mouse platelet function, Methods Mol. Biol., 272, 255 Nozawa, 2009, TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells, Proc. Natl. Acad. Sci. USA, 106, 3408, 10.1073/pnas.0805323106 O’Mahony, 2015, Serotonin, tryptophan metabolism and the brain-gut-microbiome axis, Behav. Brain Res., 277, 32, 10.1016/j.bbr.2014.07.027 Odell, 1961, Life span of mouse blood platelets, Proc. Soc. Exp. Biol. Med., 106, 107, 10.3181/00379727-106-26252 Oleskin, 1998, [Effect of serotonin (5-hydroxytryptamine) on the growth and differentiation of microorganisms], Mikrobiologiia, 67, 305 Owen, 2005, Low plasma vitamin E levels in major depression: diet or disease?, Eur. J. Clin. Nutr., 59, 304, 10.1038/sj.ejcn.1602072 Quigley, 2011, Microflora modulation of motility, J. Neurogastroenterol. Motil., 17, 140, 10.5056/jnm.2011.17.2.140 Ramage, 2008, 5-hydroxytryptamine and cardiovascular regulation, Trends Pharmacol. Sci., 29, 472, 10.1016/j.tips.2008.06.009 Reikvam, 2011, Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression, PLoS ONE, 6, e17996, 10.1371/journal.pone.0017996 Roshchina, 2010, Evolutionary considerations of neurotransmitters in microbial, plant, and animal cells, Microbial Endocrinol., 17, 10.1007/978-1-4419-5576-0_2 Savelieva, 2008, Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants, PLoS ONE, 3, e3301, 10.1371/journal.pone.0003301 Sayin, 2013, Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist, Cell Metab., 17, 225, 10.1016/j.cmet.2013.01.003 Schindelin, 2012, Fiji: an open-source platform for biological-image analysis, Nat. Methods, 9, 676, 10.1038/nmeth.2019 Schneider, 2012, NIH Image to ImageJ: 25 years of image analysis, Nat. Methods, 9, 671, 10.1038/nmeth.2089 Sekirov, 2010, Gut microbiota in health and disease, Physiol. Rev., 90, 859, 10.1152/physrev.00045.2009 Shimizu, 2003, In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells, Am. J. Respir. Crit. Care Med., 168, 581, 10.1164/rccm.200212-1437OC Sjögren, 2012, The gut microbiota regulates bone mass in mice, J. Bone Miner. Res., 27, 1357, 10.1002/jbmr.1588 Stasi, 2014, Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome, Tech. Coloproctol., 18, 613, 10.1007/s10151-013-1106-8 Stefka, 2014, Commensal bacteria protect against food allergen sensitization, Proc. Natl. Acad. Sci. USA, 111, 13145, 10.1073/pnas.1412008111 Tsavkelova, 2006, [Hormones and hormone-like substances of microorganisms: a review], Prikl. Biokhim. Mikrobiol., 42, 261 Uribe, 1994, Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat, Gastroenterology, 107, 1259, 10.1016/0016-5085(94)90526-6 Wade, 1996, Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract, J. Neurosci., 16, 2352, 10.1523/JNEUROSCI.16-07-02352.1996 Walther, 2003, Synthesis of serotonin by a second tryptophan hydroxylase isoform, Science, 299, 76, 10.1126/science.1078197 Westphal, 1994, Hepatic side-effects of antibiotics, J. Antimicrob. Chemother., 33, 387, 10.1093/jac/33.3.387 Wikoff, 2009, Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites, Proc. Natl. Acad. Sci. USA, 106, 3698, 10.1073/pnas.0812874106 Williams, 2014, Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine, Cell Host Microbe, 16, 495, 10.1016/j.chom.2014.09.001 Yadav, 2008, Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum, Cell, 135, 825, 10.1016/j.cell.2008.09.059 Yoshimoto, 2013, Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome, Nature, 499, 97, 10.1038/nature12347 Zhao, 2010, Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans, J. Agric. Food Chem., 58, 4844, 10.1021/jf904464u Ziu, 2012, Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin, J. Mol. Cell. Cardiol., 52, 1112, 10.1016/j.yjmcc.2012.02.004