What the Myddosome structure tells us about the initiation of innate immunity

Trends in Immunology - Tập 32 - Trang 104-109 - 2011
Nicholas J. Gay1, Monique Gangloff1, Luke A.J. O’Neill2
1Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK CB2 1GA
2School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

Tài liệu tham khảo

O’Neill, 2007, The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling, Nat. Rev. Immunol., 7, 353, 10.1038/nri2079 Monie, 2009, Activating immunity: lessons from the TLRs and NLRs, Trends Biochem. Sci., 34, 553, 10.1016/j.tibs.2009.06.011 Hennessy, 2010, Targeting Toll-like receptors: emerging therapeutics? Nat, Rev. Drug. Discov., 9, 293, 10.1038/nrd3203 Butler, 2007, Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases, J. Biol. Chem., 282, 29729, 10.1074/jbc.M704558200 Dunne, 2010, IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal), J. Biol. Chem., 285, 18276, 10.1074/jbc.M109.098137 Keating, 2007, IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination, J. Biol. Chem., 282, 33435, 10.1074/jbc.M705266200 Gray, 2006, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction, J. Biol. Chem., 281, 10489, 10.1074/jbc.M508892200 Mansell, 2006, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation, Nat. Immunol., 7, 148, 10.1038/ni1299 McGettrick, 2006, Trif-related adapter molecule is phosphorylated by PKC{varepsilon} during Toll-like receptor 4 signaling, Proc. Natl. Acad. Sci. U.S.A., 103, 9196, 10.1073/pnas.0600462103 Carty, 2006, The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling, Nat. Immunol., 7, 1074, 10.1038/ni1382 Khor, 2007, A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis, Nat. Genet., 39, 523, 10.1038/ng1976 Ladhani, 2010, Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive Haemophilus influenzae serotype b infection in immunized children, Clin. Infect. Dis., 51, 761, 10.1086/656236 Ferwerda, 2009, Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock, Proc. Natl. Acad. Sci. U.S.A., 106, 10272, 10.1073/pnas.0811273106 von Bernuth, 2008, Pyogenic bacterial infections in humans with MyD88 deficiency, Science, 321, 691, 10.1126/science.1158298 Walsh, 2008, Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa, J. Immunol., 181, 1245, 10.4049/jimmunol.181.2.1245 Motshwene, 2009, An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4, J. Biol. Chem., 284, 25404, 10.1074/jbc.M109.022392 Lin, 2010, Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling, Nature, 465, 885, 10.1038/nature09121 Park, 2009, The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex, Nature, 458, 1191, 10.1038/nature07830 Jin, 2007, Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide, Cell, 130, 1071, 10.1016/j.cell.2007.09.008 Liu, 2008, Structural basis of toll-like receptor 3 signaling with double-stranded RNA, Science, 320, 379, 10.1126/science.1155406 Gay, 2006, Toll-like receptors as molecular switches, Nat. Rev. Immunol., 6, 693, 10.1038/nri1916 Nunez Miguel, 2007, A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins, PLoS One, 2, e788, 10.1371/journal.pone.0000788 Kagan, 2008, TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta, Nat. Immunol., 9, 361, 10.1038/ni1569 Kagan, 2006, Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling, Cell, 125, 943, 10.1016/j.cell.2006.03.047 Rowe, 2006, The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Proc. Natl. Acad. Sci. U.S.A., 103, 6299, 10.1073/pnas.0510041103 Gay, 2007, Structure and function of Toll receptors and their ligands, Annu. Rev. Biochem., 76, 141, 10.1146/annurev.biochem.76.060305.151318 Weber, 2001, The death domain superfamily: a tale of two interfaces?, Trends Biochem. Sci., 26, 475, 10.1016/S0968-0004(01)01905-3 Park, 2007, The death domain superfamily in intracellular signaling of apoptosis and inflammation, Annu. Rev. Immunol., 25, 561, 10.1146/annurev.immunol.25.022106.141656 Park, 2007, Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex, Cell, 128, 533, 10.1016/j.cell.2007.01.019 George, 2011, Two human MYD88 variants, S34Y and R98C, interfere with MYD88-IRAK4-myddosome assembly, J. Biol. Chem., 286, 1341, 10.1074/jbc.M110.159996 Moncrieffe, 2008, Assembly of oligomeric death domain complexes during Toll receptor signaling, J. Biol. Chem., 283, 33447, 10.1074/jbc.M805427200 Popovych, 2006, Dynamically driven protein allostery, Nat. Struct. Mol. Biol., 13, 831, 10.1038/nsmb1132 Scott, 2009, The Fas–FADD death domain complex structure unravels signalling by receptor clustering, Nature, 457, 1019, 10.1038/nature07606 Wang, 2010, The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations, Nat. Struct. Mol. Biol., 17, 1324, 10.1038/nsmb.1920 Gibson, 2009, Cell regulation: determined to signal discrete cooperation, Trends Biochem. Sci., 34, 471, 10.1016/j.tibs.2009.06.007