Pinaverium Reduces Symptoms of Irritable Bowel Syndrome in a Multicenter, Randomized, Controlled Trial

Hungin, 2005, Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact, Aliment Pharmacol Ther, 21, 1365, 10.1111/j.1365-2036.2005.02463.x Maxion-Bergemann, 2006, Costs of irritable bowel syndrome in the UK and US, Pharmacoeconomics, 24, 21, 10.2165/00019053-200624010-00002 CDC. Inflammatory bowel disease (IBD). Available: http://www.cdc.gov/ibd/. Accessed: September 28, 2013. Sandler, 2002, The burden of selected digestive diseases in the United States, Gastroenterology, 122, 1500, 10.1053/gast.2002.32978 Camilleri, 2008, Challenges to the therapeutic pipeline for irritable bowel syndrome: endpoints and regulatory hurdles, Gastroenterology, 135, 1877, 10.1053/j.gastro.2008.09.005 Brandt, 2009, An evidence-based position statement on the management of irritable bowel syndrome, Am J Gastroenterol, 104, S1 Camilleri, 1992, The irritable bowel syndrome: mechanisms and a practical approach to management, Ann Intern Med, 116, 1001, 10.7326/0003-4819-116-12-1001 Kellow, 1991, Enhanced perception of physiological intestinal motility in the irritable bowel syndrome, Gastroenterology, 101, 1621, 10.1016/0016-5085(91)90400-F Ritchie, 1973, Pain from distension of the pelvic colon by inflating a balloon in the irritable bowel syndrome, Gut, 6, 105 Hiatt, 1962, Mast cells in inflammatory conditions of the gastrointestinal tract, Am J Gastroenterol, 37, 541 Aggarwal, 1994, Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities, Gastroenterology, 106, 945, 10.1016/0016-5085(94)90753-6 Whitehead, 1992, Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared to subjects without bowel dysfunction, Gut, 33, 825, 10.1136/gut.33.6.825 Forte, 2012, The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide, Eur Rev Med Pharmacol Sci, 16, 25 Drossman, 2006 2012 Unnebrink, 2001, Intention-to-treat: methods for dealing with missing values in clinical trials of progressively deteriorating diseases, Stat Med, 20, 3931, 10.1002/sim.1149 Bretaudeau, 1975, [Pharmacodynamic study of the spasmolytic properties of pinaverium bromide]. Article in French, Therapie, 30, 919 Mohammadi, 2012, Do main caregivers selectively attend to pain-related stimuli in the same way the patients do?, Pain, 153, 62, 10.1016/j.pain.2011.08.021 Spiller, 1999, Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials, Am J Med, 107, 91S, 10.1016/S0002-9343(99)00086-8 Dove, 2013, Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study, Gastroenterology, 145, 329, 10.1053/j.gastro.2013.04.006