Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders
Tóm tắt
The prevalence of scleroderma‐type capillary abnormalities, as observed by in vivo microscopy, was determined in 173 patients from three rheumatic disease centers. The patients had a variety of connective tissue diseases: scleroderma (systemic sclerosis) 50; systemic lupus erythematosus 60; mixed connective tissue disease 26; Raynaud's disease 11; other rheumatic disorders 26. Enlarged and deformed capillary loops surrounded by relatively avascular areas, most prominently in the nailfolds, were found in 82% of patients with scleroderma and in 54% with mixed connective tissue disease. The rarity of these abnormalities in systemic lupus erythematosus (2%) despite the presence of Raynaud's phenomenon suggests that they are not an expression of the Raynaud's phenomenon frequently associated with scleroderma and mixed connective tissue disease. The single patient with Raynaud's disease and sclerodermatype capillary changes subsequently developed scleroderma.
Từ khóa
Tài liệu tham khảo
Jablonska S, 1975, Histopathology of scleroderma. Scleroderma and Pseudoscleroderma, 191
Maricq HR, 1977, Studies in patients with connective tissue disorders, Ninth European Conference on Microcirculation, Antwerp, 1976, Bibl Anat, 16, 135
.MaricqHR BlumeRS LeRoyEC:Wide‐field study of nailfold capillary bed in disorders of connective tissue. Sixth European Conference on Microcirculation Aalborg 1970.1971 pp116–122
Maricq HR, 1977, Variations in the skin microvascular patterns of the hand, Ninth European Conference on Microcirculation, Antwerp, 1976, Bibl Anat, 16, 164
Maricq HR, Early detection of scleroderma by in vivo capillary microscopy, In preparation
Masi AT, 1978, Clinical criteria for early diagnosed systemic sclerosis: preliminary results of the ARA Multicenter Cooperative Study, Arthritis Rheum, 21, 576
Masi AT, Methodology and preliminary results of the scleroderma criteria cooperative study of the American Rheumatism Association, In preparation