Stoffwechselprodukte von Mikroorganismen

Archiv für Mikrobiologie - Tập 61 - Trang 143-153 - 1968
K. Poralla1, H. Zähner1
1Institut für Mikrobiologie der Universität Tübingen, Tübingen, Deutschland

Tóm tắt

Es wurde die Wirkungsweise von Borrelidin untersucht und mit zwei Makrolid-Antibiotica verglichen. Borrelidin hemmt in einem zellfreien System aus Bacillus subtilis spezifisch den Einbau von Threonin in sRNS bei einer Konzentration von 1,4·10-6 m. Hingegen hemmen die Makrolid-Antibiotica Lankamycin (neutral) und Erythromycin (basisch) bei Konzentrationen, die zehnmal höher liegen als die wachstumshemmende Konzentration, nicht die Verknüpfung von Threonin oder anderer Aminosäuren mit sRNS. In Zellen hemmt Borrelidin bei einer Konzentration von 1,5–3·10-6 m die Synthese von Protein, RNS und DNS. Lankamycin und Erythromycin hingegen hemmen nur die Synthese von Protein. Es wird vermutet, daß Borrelidin das erste Antibioticum ist, das die Protein-synthese über die Hemmung des Einbaus von Aminosäuren in sRNS blockiert.

Tài liệu tham khảo

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