Alterations in intestinal fatty acid metabolism in inflammatory bowel disease

Susanne Heimerl1, Christoph Moehle1, Alexandra Zahn2, Alfred Boettcher1, Wolfgang Stremmel2, Thomas Langmann1, Gerd Schmitz1
1Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany
2Institute of Internal Medicine IV, University of Heidelberg, 69115 Heidelberg, Germany

Tài liệu tham khảo

Mizoguchi, 2003, Immune networks in animal models of inflammatory bowel disease, Inflamm. Bowel Dis., 9, 246, 10.1097/00054725-200307000-00005 Targan, 2000, Biology of inflammation in Crohn's disease: mechanisms of action of anti-TNF—A therapy, Can. J. Gastroenterol., 14, 13C, 10.1155/2000/409396 Wang, 2005, Tumor necrosis factor family members and inflammatory bowel disease, Immunol. Rev., 204, 144, 10.1111/j.0105-2896.2005.00218.x Podolsky, 1999, Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense, Am. J. Physiol., 277, G495 Donnet-Hughes, 2001, The intestinal mucosa as a target for dietary polyunsaturated fatty acids, Lipids, 36, 1043, 10.1007/s11745-001-0815-4 Miller, 2004, Cellular and physiological effects of short-chain fatty acids, Mini. Rev. Med. Chem., 4, 839, 10.2174/1389557043403288 Roediger, 1980, Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man, Gut, 21, 793, 10.1136/gut.21.9.793 Scheppach, 1997, Effects of short-chain fatty acids on the inflamed colonic mucosa, Scand. J. Gastroenterol., Suppl., 222, 53, 10.1080/00365521.1997.11720719 Harig, 1989, Treatment of diversion colitis with short-chain-fatty acid irrigation, N. Engl. J. Med., 320, 23, 10.1056/NEJM198901053200105 Ireland, 1990, Acetylation of 5-aminosalicylic acid by isolated human colonic epithelial cells, Clin. Sci. (Lond), 78, 105, 10.1042/cs0780105 Sakata, 1995, Local stimulatory effect of short-chain fatty acids on the mucus release from the hindgut mucosa of rats (Rattus norvegicus), Comp. Biochem. Physiol., A Physiol., 111, 429, 10.1016/0300-9629(95)00033-4 Kinoshita, 2002, Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation, Biochem. Biophys. Res. Commun., 293, 827, 10.1016/S0006-291X(02)00294-2 Belluzzi, 2002, N-3 fatty acids for the treatment of inflammatory bowel diseases, Proc. Nutr. Soc., 61, 391, 10.1079/PNS2002171 Usami, 2003, Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation, Nutrition, 19, 150, 10.1016/S0899-9007(02)00927-9 Barbosa, 2003, Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids, Nutrition, 19, 837, 10.1016/S0899-9007(03)00162-X Simopoulos, 2002, Omega-3 fatty acids in inflammation and autoimmune diseases, J. Am. Coll. Nutr., 21, 495, 10.1080/07315724.2002.10719248 Kabashima, 2002, The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut, J. Clin. Invest., 109, 883, 10.1172/JCI0214459 Nitta, 2002, Expression of the EP4 prostaglandin E2 receptor subtype with rat dextran sodium sulphate colitis: colitis suppression by a selective agonist, ONO-AE1-329, Scand. J. Immunol., 56, 66, 10.1046/j.1365-3083.2002.01096.x Sasaki, 2000, Prostaglandin E2 inhibits lesion formation in dextran sodium sulphate-induced colitis in rats and reduces the levels of mucosal inflammatory cytokines, Scand. J. Immunol., 51, 23, 10.1046/j.1365-3083.2000.00623.x Bassaganya-Riera, 2004, Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease, Gastroenterology, 127, 777, 10.1053/j.gastro.2004.06.049 Dubuquoy, 2003, Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis, Gastroenterology, 124, 1265, 10.1016/S0016-5085(03)00271-3 Katayama, 2003, A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model, Gastroenterology, 124, 1315, 10.1016/S0016-5085(03)00262-2 Langmann, 2004, Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes, Gastroenterology, 127, 26, 10.1053/j.gastro.2004.04.019 Langmann, 2003, Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues, Clin. Chem., 49, 230, 10.1373/49.2.230 Joseph, 2002, Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors, J. Biol. Chem., 277, 11019, 10.1074/jbc.M111041200 Repa, 2000, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta, Genes Dev., 14, 2819, 10.1101/gad.844900 Yoshikawa, 2001, Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter, Mol. Cell. Biol., 21, 2991, 10.1128/MCB.21.9.2991-3000.2001 Eckmann, 1993, Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8, Gastroenterology, 105, 1689, 10.1016/0016-5085(93)91064-O Shenoy, 2004, CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor, Drug Metab. Dispos., 32, 66, 10.1124/dmd.32.1.66 Jobin, 2000, The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection, Am. J. Physiol., Cell Physiol., 278, C451, 10.1152/ajpcell.2000.278.3.C451 Stahl, 2004, A current review of fatty acid transport proteins (SLC27), Pflugers Arch., 447, 722, 10.1007/s00424-003-1106-z Stahl, 1999, Identification of the major intestinal fatty acid transport protein, Mol. Cell, 4, 299, 10.1016/S1097-2765(00)80332-9 Stahl, 2004, A current review of fatty acid transport proteins (SLC27), Pflugers Arch., 447, 722, 10.1007/s00424-003-1106-z Goudriaan, 2002, Intestinal lipid absorption is not affected in CD36 deficient mice, Mol. Cell Biochem., 239, 199, 10.1023/A:1020575412789 Drover, 2005, CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood, J. Clin. Invest., 115, 1290, 10.1172/JCI21514 Besnard, 2002, New insights into the fatty acid-binding protein (FABP) family in the small intestine, Mol. Cell Biochem., 239, 139, 10.1023/A:1020505512364 Glatz, 1995, Fatty acids in cell signalling: modulation by lipid binding proteins, Prostaglandins, Leukot. Essent. Fat. Acids, 52, 121, 10.1016/0952-3278(95)90010-1 Coleman, 2002, Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?, J. Nutr., 132, 2123, 10.1093/jn/132.8.2123 Swinnen, 2003, Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains, Biochem. Biophys. Res. Commun., 302, 898, 10.1016/S0006-291X(03)00265-1 Li, 2000, Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia, Exp. Cell Res., 261, 159, 10.1006/excr.2000.5054 Jackowski, 2000, Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution of fatty acids into glycerolipids in proliferating cells, Biochim. Biophys. Acta, 1483, 301, 10.1016/S1388-1981(99)00203-6 Pizer, 1996, Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells, Cancer Res., 56, 745 Horton, 2003, Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes, Proc. Natl. Acad. Sci. U. S. A., 100, 12027, 10.1073/pnas.1534923100 Ehehalt, 2004, Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoElectrospray-tandem mass spectrometry, Scand. J. Gastroenterol., 39, 737, 10.1080/00365520410006233 Lichtenberger, 1995, The hydrophobic barrier properties of gastrointestinal mucus, Annu. Rev. Physiol., 57, 565, 10.1146/annurev.ph.57.030195.003025 Wang, 2004, LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1, J. Lipid Res., 45, 972, 10.1194/jlr.M400011-JLR200 Kliewer, 1998, An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway, Cell, 92, 73, 10.1016/S0092-8674(00)80900-9 Schoonjans, 1997, Peroxisome proliferator-activated receptors, orphans with ligands and functions, Curr. Opin. Lipidol., 8, 159, 10.1097/00041433-199706000-00006 Aranda, 2001, Nuclear hormone receptors and gene expression, Physiol. Rev., 81, 1269, 10.1152/physrev.2001.81.3.1269 Chawla, 2001, Nuclear receptors and lipid physiology: opening the X-files, Science, 294, 1866, 10.1126/science.294.5548.1866 Beigneux, 2000, The acute phase response is associated with retinoid X receptor repression in rodent liver, J. Biol. Chem., 275, 16390, 10.1074/jbc.M000953200 Khovidhunkit, 2003, Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR, J. Lipid Res., 44, 1728, 10.1194/jlr.M300100-JLR200 Remaley, 2002, Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster, Biochem. Biophys. Res. Commun., 295, 276, 10.1016/S0006-291X(02)00652-6 Repa, 2002, Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta, J. Biol. Chem., 277, 18793, 10.1074/jbc.M109927200 Costet, 2000, Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor, J. Biol. Chem., 275, 28240, 10.1074/jbc.M003337200 Venkateswaran, 2000, Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols, J. Biol. Chem., 275, 14700, 10.1074/jbc.275.19.14700 Fowler, 2003, Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production, J. Invest. Dermatol., 120, 246, 10.1046/j.1523-1747.2003.12033.x