Control of transposon activity by a histone H3K4 demethylase in rice

Proceedings of the National Academy of Sciences of the United States of America - Tập 110 Số 5 - Trang 1953-1958 - 2013
Xiekui Cui1,2, Ping Jin3,4, Xia Cui1, Lianfeng Gu1, Zhike Lu1, Yongming Xue1,2, Liya Wei1,2, Jianfei Qi1, Xianwei Song1, Ming Luo5, Gynheung An3, Xiaofeng Cao1
1State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2University of Chinese Academy of Sciences, Beijing 100039, China
3Crop Biotech Institute, Kyung Hee University, Yongin 446-701, Korea;
4Department of Life Science, Pohang University of Science and Technology, Pohang 790-784, Korea; and
5Commonwealth Scientific and Industrial Research Organization, Plant Industry, Canberra ACT 2601, Australia.

Tóm tắt

Transposable elements (TEs) are ubiquitously present in plant genomes and often account for significant fractions of the nuclear DNA. For example, roughly 40% of the rice genome consists of TEs, many of which are retrotransposons, including 14% LTR- and ∼1% non-LTR retrotransposons. Despite their wide distribution and abundance, very few TEs have been found to be transpositional, indicating that TE activities may be tightly controlled by the host genome to minimize the potentially mutagenic effects associated with active transposition. Consistent with this notion, a growing body of evidence suggests that epigenetic silencing pathways such as DNA methylation, RNA interference, and H3K9me2 function collectively to repress TE activity at the transcriptional and posttranscriptional levels. It is not yet clear, however, whether the removal of histone modifications associated with active transcription is also involved in TE silencing. Here, we show that the rice protein JMJ703 is an active H3K4-specific demethylase required for TEs silencing. Impaired JMJ703 activity led to elevated levels of H3K4me3, the misregulation of numerous endogenous genes, and the transpositional reactivation of two families of non-LTR retrotransposons. Interestingly, loss of JMJ703 did not affect TEs (such as Tos17 ) previously found to be silenced by other epigenetic pathways. These results indicate that the removal of active histone modifications is involved in TE silencing and that different subsets of TEs may be regulated by distinct epigenetic pathways.

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Thông tin xuất bản

Proceedings of the National Academy of Sciences of the United States of America

Tập 110 Số 5

1953-1958

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