Clinicians’ response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO2

Aafke E. de Graaff1, Dave A. Dongelmans1, Jan M. Binnekade1, Evert de Jonge2
1Department of Intensive Care Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
2Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands

Tóm tắt

Từ khóa


Tài liệu tham khảo

Pinhu L, Whitehead T, Evans T, Griffiths M (2003) Ventilator-associated lung injury. Lancet 361:332–340

Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308

Bhandari V, Elias JA (2006) Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung. Free Radic Biol Med 41:4–18

Aboab J, Jonson B, Kouatchet A, Taille S, Niklason L, Brochard L (2006) Effect of inspired oxygen fraction on alveolar derecruitment in acute respiratory distress syndrome. Intensive Care Med 32:1979–1986

Tobin MJ (1994) Mechanical ventilation. N Engl J Med 330:1056–1061

Mao C, Wong DT, Slutsky AS, Kavanagh BP (1999) A quantitative assessment of how Canadian intensivists believe they utilize oxygen in the intensive care unit. Crit Care Med 27:2806–2811

Lachmann B (1992) Open up the lung and keep the lung open. Intensive Care Med 18:319–321

Jackson RM (1985) Pulmonary oxygen toxicity. Chest 88:900–905

Crapo JD, Hayatdavoudi G, Knapp MJ, Fracica PJ, Wolfe WG, Piantadosi CA (1994) Progressive alveolar septal injury in primates exposed to 60% oxygen for 14 days. Am J Physiol 267:L797–L806

Sinclair SE, Altemeier WA, Matute-Bello G, Chi EY (2004) Augmented lung injury due to interaction between hyperoxia and mechanical ventilation. Crit Care Med 32:2496–2500

Kavanagh BP (1998) Goals and concerns for oxygenation in acute respiratory distress syndrome. Curr Opin Crit Care 4:16–20

Quinlan GJ, Lamb NJ, Tilley R, Evans TW, Gutteridge JMC (1997) Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity and mortality. Am J Respir Crit Care Med 155:479–484

Li LF, Liao SK, Ko YS, Lee CH, Quinn DA (2007) Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment. Crit Care 11:R25

Griffith DE, Garcia JG, James HL, Callahan KS, Iriana S, Holiday D (1992) Hyperoxic exposure in humans. Effects of 50 percent oxygen on alveolar macrophage leukotriene B4 synthesis. Chest 101:392–397

Nagato A, Silva FL, Silva AR, Bezerra FS, Oliveira ML, Belló-Klein A, Porto LC, Valenca SS (2009) Hyperoxia-induced lung injury is dose dependent in Wistar rats. Exp Lung Res 35:713–728

Altemeier WA, Sinclair SE (2007) Hyperoxia in the intensive care unit: why is more not always better. Curr Opin Crit Care 13:73–78

Pilon CS, Leathley M, London R, McLean S, Phang PT, Priestley R, Rosenberg FM, Singer J, Anis AH, Dodek PM (1997) Practice guideline for arterial blood gas measurement in the intensive care unit decreases numbers and increases appropriateness of tests. Crit Care Med 25:1308–1313

Merlani P, Garnerin P, Diby M, Ferring M, Ricou B (2001) Linking guideline to regular feedback to increase appropriate requests for clinical tests: blood gas analysis in intensive care. BMJ 323:620–624

Rice TW, Wheeler AP, Bernard GR, Hayden DL, Schoenfeld DA, Ware LB (2007) Comparison of the SpO2/FiO2 ratio and the PaO2/FiO2 ratio in patients with acute lung injury or ARDS. Chest 132:410–417

Wolthuis EK, Korevaar JC, Spronk P, Kuiper MA, Dzoljic M, Vroom MB, Schultz MJ (2005) Feedback and education improve physician compliance in use of lung-protective mechanical ventilation. Intensive Care Med 31:540–546