Interleukin-6 in the aging brain

Bauer, 1991, Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices, FEBS Lett., 285, 111, 10.1016/0014-5793(91)80737-N

Beharka, 2001, Interleukin-6 production does not increase with age, J. Gerontol., Ser. A, Biol. Sci. Med. Sci., 278, B81, 10.1093/gerona/56.2.B81

Bonni, 1997, Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway, Science, 278, 477, 10.1126/science.278.5337.477

Campbell, 1993, Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6, Proc. Natl. Acad. Sci. U. S. A., 90, 10061, 10.1073/pnas.90.21.10061

Daynes, 1993, Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative, J. Immunol., 150, 5219, 10.4049/jimmunol.150.12.5219

Ershler, 2000, Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty, Annu. Rev. Med., 51, 245, 10.1146/annurev.med.51.1.245

Fattori, 1995, IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage, Eur. J. Neurosci., 7, 2441, 10.1111/j.1460-9568.1995.tb01042.x

Gould, 1999, Learning enhances adult neurogenesis in the hippocampal formation, Nat. Neurosci., 2, 260, 10.1038/6365

Griffin, 1994, Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression, Neurosci. Lett., 176, 133, 10.1016/0304-3940(94)90066-3

Gross, 2000, Neurogenesis in the adult brain: death of a dogma, Nat. Rev., Neurosci., 1, 67, 10.1038/35036235

Heyser, 1997, Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain, Proc. Natl. Acad Sci. U. S. A., 94, 1500, 10.1073/pnas.94.4.1500

Huell, 1995, Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients, Acta Neuropathol., 89, 544, 10.1007/BF00571510

Irizarry, 1997, A beta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse, J. Neurosci., 17, 7053, 10.1523/JNEUROSCI.17-18-07053.1997

Kalman, 1997, Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease, Acta Neurol. Scand., 96, 236, 10.1111/j.1600-0404.1997.tb00275.x

Korhonen, 1997, Age-related changes in the regulation of transcription factor NF-kappa B in rat brain, Neurosci. Lett., 225, 61, 10.1016/S0304-3940(97)00190-0

Li, 1999, Is NF-kappa B the sensor of oxidative stress?, FASEB J., 13, 1137, 10.1096/fasebj.13.10.1137

Li, 1997, Interleukin-6 inhibits long-term potentiation in rat hippocampal slices, Brain Res., 748, 30, 10.1016/S0006-8993(96)01283-8

Libermann, 1990, Activation of interleukin-6 gene expression through the NF-kappa B transcription factor, Mol. Cell. Biol., 10, 2327, 10.1128/MCB.10.5.2327

Lorton, 1996, Beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes, J. Neuroimmunol., 67, 21, 10.1016/0165-5728(96)00030-6

McRae, 1997, Microglial in neurodegenerative disorders: emphasis on Alzheimer's disease, Gerontology, 43, 95, 10.1159/000213838

Mrak, 1995, Glial cytokines in Alzheimer's disease: review and pathogenic implications, Hum. Pathol., 26, 816, 10.1016/0046-8177(95)90001-2

Papanicolaou, 1998, The pathophysiologic roles of interleukin-6 in human disease, Ann. Intern. Med., 128, 127, 10.7326/0003-4819-128-2-199801150-00009

Poynter, 1999, Age-associated alterations in splenic iNOS regulation: influence of constitutively expressed IFN-gamma and correction following supplementation with PPARalpha activators or vitamin E, Cell. Immunol., 195, 127, 10.1006/cimm.1999.1525

Prechel, 1996, Increased interleukin-6 production by cerebral cortical tissue of adult versus young mice, Mech. Ageing Dev., 92, 185, 10.1016/S0047-6374(96)01833-7

Qiu, 1998, Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons, J. Neurosci., 18, 10445, 10.1523/JNEUROSCI.18-24-10445.1998

Reyes, 1999, Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli, Brain Res., 851, 215, 10.1016/S0006-8993(99)02189-7

Shors, 2001, Neurogenesis in the adult is involved in the formation of trace memories, Nature, 410, 372, 10.1038/35066584

Spencer, 1997, Constitutive activation of NF-kappa B in an animal model of aging, Int. Immunol., 9, 1581, 10.1093/intimm/9.10.1581

Taga, 1997, Gp130 and the interleukin-6 family of cytokines, Annu. Rev. Immunol., 15, 797, 10.1146/annurev.immunol.15.1.797

Terai, 1996, Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease, Brain Res., 735, 159, 10.1016/0006-8993(96)00310-1

Toliver-Kinsky, 1997, Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity, J. Neurosci. Res., 48, 580, 10.1002/(SICI)1097-4547(19970615)48:6<580::AID-JNR11>3.0.CO;2-Z

Vallieres, 2002, Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6, J. Neurosci., 22, 486, 10.1523/JNEUROSCI.22-02-00486.2002

Weaver, 2002, Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging, Neurology, 59, 371, 10.1212/WNL.59.3.371

Wei, 1992, Increase of plasma IL-6 concentration with age in healthy subjects, Life Sci., 51, 1953, 10.1016/0024-3205(92)90112-3

Woodroofe, 1991, Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production, J. Neuroimmunol., 33, 227, 10.1016/0165-5728(91)90110-S

Ye, 1999, Increased interleukin-6 expression by microglia from brain of aged mice, J. Neuroimmunol., 93, 139, 10.1016/S0165-5728(98)00217-3

Ye, 2001, Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kappa B, J Neuroimmunol., 117, 87, 10.1016/S0165-5728(01)00316-2

Ye, 2001, An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice, Neuroimmunomodulation, 9, 183, 10.1159/000049025