Real-world serological responses to extended-interval and heterologous COVID-19 mRNA vaccination in frail, older people (UNCoVER): an interim report from a prospective observational cohort study

The Lancet Healthy Longevity - Tập 3 - Trang e166-e175 - 2022
Donald C Vinh1,2, Jean-Philippe Gouin3,4, Diana Cruz-Santiago3,5, Michelle Canac-Marquis1, Stéphane Bernier1, Florian Bobeuf3, Avik Sengupta1, Jean-Philippe Brassard1, Alyssa Guerra1, Robert Dziarmaga1, Anna Perez1, Yichun Sun1, Yongbiao Li1, Lucie Roussel1, Mélanie J Langelier1, Danbing Ke6, Corey Arnold7, Marilyn Whelan7, Martin Pelchat7,8, Marc-André Langlois7,8
1Infectious Diseases and Immunity in Global Health program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada
2Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montréal, QC, Canada
3Centre de recherche de l'Institut de gériatrie de Montréal, Montréal, QC, Canada
4Department of Psychology, Faculty of Arts and Sciences, Concordia University, Montréal, QC, Canada
5Département de médecine de famille et médecine urgence, Université de Montréal, Montréal, QC, Canada
6Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, QC, Canada
7Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
8uOttawa Center for Infection, Immunity and Inflammation (CI3), Ottawa, ON, Canada

Tài liệu tham khảo

Onder, 2020, Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy, JAMA, 323, 1775 Pastor-Barriuso, 2020, Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study, BMJ, 371 Baden, 2021, Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine, N Engl J Med, 384, 403, 10.1056/NEJMoa2035389 Polack, 2020, Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine, N Engl J Med, 383, 2603, 10.1056/NEJMoa2034577 Iversen, 2021, Extending the interval of COVID-19 vaccine regimens in individuals aged 80 years or older, Lancet Healthy Longev, 2, e529, 10.1016/S2666-7568(21)00205-1 Rockwood, 2005, A global clinical measure of fitness and frailty in elderly people, CMAJ, 173, 489, 10.1503/cmaj.050051 Olivier, 2008, The logarithmic transformation and the geometric mean in reporting experimental IgE results: what are they and when and why to use them?, Ann Allergy Asthma Immunol, 100, 333, 10.1016/S1081-1206(10)60595-9 Parry, 2021, Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people, Immun Ageing, 18, 34, 10.1186/s12979-021-00246-9 Tut, 2021, Profile of humoral and cellular immune responses to single doses of BNT162b2 or ChAdOx1 nCoV-19 vaccines in residents and staff within residential care homes (VIVALDI): an observational study, Lancet Healthy Longev, 2, e544, 10.1016/S2666-7568(21)00168-9 Richards, 2021, Comparison of SARS-CoV-2 antibody response by age among recipients of the BNT162b2 vs the mRNA-1273 vaccine, JAMA Netw Open, 4, 10.1001/jamanetworkopen.2021.24331 Steensels, 2021, Comparison of SARS-CoV-2 antibody response following vaccination with BNT162b2 and mRNA-1273, JAMA, 326, 1533, 10.1001/jama.2021.15125 Boyarsky, 2021, Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients, JAMA, 325, 2204, 10.1001/jama.2021.7489 Barros-Martins, 2021, Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination, Nat Med, 27, 1525, 10.1038/s41591-021-01449-9 Schmidt, 2021, Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination, Nat Med, 27, 1530, 10.1038/s41591-021-01464-w Gustafson, 2020, Influence of immune aging on vaccine responses, J Allergy Clin Immunol, 145, 1309, 10.1016/j.jaci.2020.03.017 Collier, 2021, Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2, Nature, 596, 417, 10.1038/s41586-021-03739-1 Müller, 2021, Age-dependent immune response to the Biontech/Pfizer BNT162b2 COVID-19 vaccination, Clin Infect Dis, 73, 2065, 10.1093/cid/ciab381 Fink, 2018, The evolution of greater humoral immunity in females than males: implications for vaccine efficacy, Curr Opin Physiol, 6, 16, 10.1016/j.cophys.2018.03.010 Kurupati, 2016, Race-related differences in antibody responses to the inactivated influenza vaccine are linked to distinct pre-vaccination gene expression profiles in blood, Oncotarget, 7, 62898, 10.18632/oncotarget.11704