Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism

Journal of Hepatology - Tập 68 - Trang 922-931 - 2018
Congrong Niu1, Li Li1, Stephane Daffis2, Julie Lucifora3, Marc Bonnin3, Sarah Maadadi3, Eduardo Salas1, Ruth Chu1, Hilario Ramos1, Christine M. Livingston1, Rudolf K. Beran1, Abhishek V. Garg1, Scott Balsitis1, David Durantel3, Fabien Zoulim3,4,5, William E. Delaney1, Simon P. Fletcher1
1Gilead Sciences, Inc., Foster City, CA, USA
2Gilead Sciences Inc, Foster City, CA, USA
3INSERM 1052, Université Claude Bernard Lyon 1, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon 69003, France
4Hospices Civils de Lyon (HCL), 69002 Lyon, France
5Institut Universitaire de France (IUF), 75005 Paris, France

Tài liệu tham khảo

Roethle, 2013, Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis, J Med Chem, 56, 7324, 10.1021/jm400815m Akira, 2004, Toll-like receptor signalling, Nat Rev Immunol, 4, 499, 10.1038/nri1391 Birmachu, 2007, Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists, BMC Immunol, 8, 26, 10.1186/1471-2172-8-26 Hanten, 2008, Comparison of human B cell activation by TLR7 and TLR9 agonists, BMC Immunol, 9, 39, 10.1186/1471-2172-9-39 Oh, 2011, TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway, Blood, 118, 3028, 10.1182/blood-2011-04-348839 Lanford, 2013, GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees, Gastroenterology, 144, 1508, 10.1053/j.gastro.2013.02.003 Menne, 2015, Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the woodchuck model of chronic hepatitis B, J Hepatol, 62, 1237, 10.1016/j.jhep.2014.12.026 Isorce, 2016, Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus, Antiviral Res, 130, 36, 10.1016/j.antiviral.2016.03.008 Lutgehetmann, 2011, Hepatitis B virus limits response of human hepatocytes to interferon-alpha in chimeric mice, Gastroenterology, 140, 2074, 10.1053/j.gastro.2011.02.057 Niu, 2017, The Smc5/6 complex restricts HBV when localized to ND10 without inducing an innate immune response and is counteracted by the HBV X protein shortly after infection, PLoS One, 12, e0169648, 10.1371/journal.pone.0169648 Schoggins, 2011, A diverse range of gene products are effectors of the type I interferon antiviral response, Nature, 472, 481, 10.1038/nature09907 Li, 2012, MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen, Hepatology, 56, 803, 10.1002/hep.25608 Yan, 2015, Interferon-inducible protein tetherin inhibits hepatitis B virus virion secretion, J Virol, 89, 9200, 10.1128/JVI.00933-15 Lucifora, 2014, Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA, Science, 343, 1221, 10.1126/science.1243462 Xia, 2016, Interferon-gamma and tumor necrosis factor-alpha produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis, Gastroenterology, 150, 194, 10.1053/j.gastro.2015.09.026 Decorsière, 2016, Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor, Nature, 531, 386, 10.1038/nature17170 Gehring, 2007, The level of viral antigen presented by hepatocytes influences CD8 T-cell function, J Virol, 81, 2940, 10.1128/JVI.02415-06 Robek, 2007, Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus, J Virol, 81, 483, 10.1128/JVI.01779-06 Sastry, 2011, Targeting hepatitis B virus-infected cells with a T-cell receptor-like antibody, J Virol, 85, 1935, 10.1128/JVI.01990-10 Allweiss, 2014, Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration, J Hepatol, 60, 500, 10.1016/j.jhep.2013.10.021 Isogawa, 2005, Toll-like receptor signaling inhibits hepatitis B virus replication in vivo, J Virol, 79, 7269, 10.1128/JVI.79.11.7269-7272.2005 Li, 2018, Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells, J Hepatol, 68, 912, 10.1016/j.jhep.2017.12.008 Belloni, 2012, IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome, J Clin Invest, 122, 529, 10.1172/JCI58847 Tropberger, 2015, Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation, Proc Natl Acad Sci U S A, 112, E5715, 10.1073/pnas.1518090112 Riviere, 2015, HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase, J Hepatol, 63, 1093, 10.1016/j.jhep.2015.06.023 Wieland, 2004, Genomic analysis of the host response to hepatitis B virus infection, Proc Natl Acad Sci U S A, 101, 6669, 10.1073/pnas.0401771101 Fisicaro, 2012, Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV, Gastroenterology, 143, 1576, 10.1053/j.gastro.2012.08.041 Cheng, 2017, Hepatitis B virus evades innate immunity of hepatocytes but activates macrophages during infection, Hepatology, 10.1002/hep.29348 Thomsen, 2016, Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection, Hepatology, 64, 746, 10.1002/hep.28685 Fletcher, 2013, Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B, Hepatology, 57, 13, 10.1002/hep.25954 Dunn, 2009, Temporal analysis of early immune responses in patients with acute hepatitis B virus infection, Gastroenterology, 137, 1289, 10.1053/j.gastro.2009.06.054 Luangsay, 2015, Early inhibition of hepatocyte innate responses by hepatitis B virus, J Hepatol, 63, 1314, 10.1016/j.jhep.2015.07.014