Hematologic Nadirs During Chemoradiation for Anal Cancer: Temporal Characterization and Dosimetric Predictors

Andrew Y. Lee1, Daniel W. Golden1, Jose G. Bazan2, Malgorzata Kopec1, Charles A. Pelizzari1, Sonya Aggarwal3, Daniel T. Chang3, Stanley L. Liauw1
1Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois
2Department of Radiation Oncology, The Ohio State University, Columbus, Ohio
3Department of Radiation Oncology, Stanford University, Stanford, California

Tài liệu tham khảo

1996, Epidermoid anal cancer: Results from the UKCCCR randomized trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Coordinating Committee on Cancer Research, Lancet, 346, 1049 DeVita, 2008, Cancer of the anal region, 1305 Cummings, 2008, Anal cancer, 1383 James, 2013, Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): A randomised, phase 3, open-label, 2x2 factorial trial, Lancet Oncol, 14, 516, 10.1016/S1470-2045(13)70086-X Ajani, 2008, Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: A randomized controlled trial, JAMA, 299, 1914, 10.1001/jama.299.16.1914 Ben-Josef, 2010, Impact of overall treatment time on survival and local control in patients with anal cancer: A pooled data analysis of Radiation Therapy Oncology Group trials 87-04 and 98-11, J Clin Oncol, 28, 5061, 10.1200/JCO.2010.29.1351 Constantinou, 1997, Time-dose considerations in the treatment of anal cancer, Int J Radiat Oncol Biol Phys, 39, 651, 10.1016/S0360-3016(97)00329-5 Mell, 2006, Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy, Int J Radiat Oncol Biol Phys, 66, 1356, 10.1016/j.ijrobp.2006.03.018 Mell, 2008, Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy, Int J Radiat Oncol Biol Phys, 70, 1431, 10.1016/j.ijrobp.2007.08.074 Bazan, 2012, Normal tissue complication probability modeling of acute hematologic toxicity in patients treated with intensity-modulated radiation therapy for squamous cell carcinoma of the anal canal, Int J Radiat Oncol Biol Phys, 84, 700, 10.1016/j.ijrobp.2011.12.072 Bazan, 2013, Impact of chemotherapy on normal tissue complication probability models of acute hematologic toxicity in patients receiving pelvic intensity modulated radiation therapy, Int J Radiat Oncol Biol Phys, 87, 983, 10.1016/j.ijrobp.2013.09.017 Cheng, 2014, Lumbosacral spine and marrow cavity modeling of acute hematologic toxicity in patients treated with intensity modulated radiation therapy for squamous cell carcinoma of the anal canal, Pract Radiat Oncol, 4, 198, 10.1016/j.prro.2013.07.011 Zhu, 2015, Longitudinal study of acute haematologic toxicity in cervical cancer patients treated with chemoradiotherapy, J Med Imaging Radiat Oncol, 59, 386, 10.1111/1754-9485.12297 Rose, 2011, Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy, Int J Radiat Oncol Biol Phys, 79, 800, 10.1016/j.ijrobp.2009.11.010 Rose, 2016, Irradiation of FDG-PET-defined active bone marrow subregions and acute hematologic toxicity in anal cancer patients undergoing chemoradiation, Int J Radiat Oncol Biol Phys, 94, 747, 10.1016/j.ijrobp.2015.12.006 2010 Meyerhardt, 2004, Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: Findings from Intergroup Trial 0114, J Clin Oncol, 22, 648, 10.1200/JCO.2004.07.121 Sambuceti, 2012, Estimating the whole bone-marrow asset in humans by a computational approach to integrated PET/CT imaging, Eur J Nucl Med Mol Imaging, 39, 1326, 10.1007/s00259-012-2141-9 Goryawala, 2015, Proliferative and glycolytic assessment of the whole-body bone marrow compartment, Mol Imaging Radionucl Ther, 24, 71, 10.4274/mirt.22931 Constine, 2008, Techniques, modalities, and modifiers in radiation oncology, 348 Schefter, 2005, A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases, Int J Radiat Oncol Biol Phys, 62, 1371, 10.1016/j.ijrobp.2005.01.002 Clift, 1994, Marrow transplantation for chronic myeloid leukemia: A randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide, Blood, 84, 2036, 10.1182/blood.V84.6.2036.2036 Albuquerque, 2011, Radiation-related predictors of hematologic toxicity after concurrent chemoradiation for cervical cancer and implications for bone marrow-sparing pelvic IMRT, Int J Radiat Oncol Biol Phys, 79, 1043, 10.1016/j.ijrobp.2009.12.025 Yang, 2014, Clinical and dosimetric predictors of acute hematologic toxicity in rectal cancer patients undergoing chemoradiotherapy, Radiother Oncol, 113, 29, 10.1016/j.radonc.2014.09.002