Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis

The Lancet - Tập 379 - Trang 2063-2071 - 2012
Stefan Leucht1, Magdolna Tardy1, Katja Komossa1, Stephan Heres1, Werner Kissling1, Georgia Salanti2, John M Davis3,4
1Department of Psychiatry and Psychotherapy, Technische Universität München, Klinikum rechts der Isar, Munich, Germany
2Department of Hygiene and Epidemiology, University of Ioannina School of Medicine University Campus Ioannina, Ioannina, Greece
3Psychiatric Institute, University of Illinois at Chicago, Chicago, IL, USA
4Maryland Psychiatric Research Center, Baltimore, MD, USA

Tài liệu tham khảo

Robinson, 1999, Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder, Arch Gen Psychiatry, 56, 241, 10.1001/archpsyc.56.3.241 Shepherd, 1989, The natural history of schizophrenia: a five-year follow-up study of outcome and prediction in a representative sample of schizophrenics, Psychol Med Suppl, 15, 1, 10.1017/S026418010000059X Gilbert, 1995, Neuroleptic withdrawal in schizophrenic patients: a review of the literature, Arch Gen Psychiatry, 52, 173, 10.1001/archpsyc.1995.03950150005001 Kane, 2003, Optimising pharmacologic treatment of psychotic disorders, J Clin Psychiatry, 64, 1 Robinson, 1999, Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder, Am J Psychiatry, 156, 544, 10.1176/ajp.156.4.544 Davis, 1975, Overview: maintenance therapy in psychiatry: I Schizophrenia, Am J Psychiatry, 132, 1237, 10.1176/ajp.132.12.1237 Ray, 2009, Atypical antipsychotic drugs and the risk of sudden cardiac death, N Engl J Med, 360, 225, 10.1056/NEJMoa0806994 Tiihonen, 2009, 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study), Lancet, 374, 620, 10.1016/S0140-6736(09)60742-X 2010 Tiihonen, 2011, A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia, Am J Psychiatry, 168, 603, 10.1176/appi.ajp.2011.10081224 2009 Leucht, 2003, Relapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials, Am J Psychiatry, 160, 1209, 10.1176/appi.ajp.160.7.1209 Chouinard, 1980, Lack of tolerance to long-term neuroleptic treatment in dopamine tuberoinfundibular system, Acta Psychiatr Scand, 64, 353, 10.1111/j.1600-0447.1981.tb00794.x Komossa Higgins, 2008 Carpenter, 1990, Continuous versus targeted medication in schizophrenic outpatients: outcome results, Am J Psychiatry, 147, 1138 DerSimonian, 1986, Meta-analysis in clinical trials, Contr Clin Trials, 7, 177, 10.1016/0197-2456(86)90046-2 Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557 Viguera, 1997, Clinical risk following abrupt and gradual withdrawal of maintenance neuroleptic treatment, Arch Gen Psychiatry, 54, 49, 10.1001/archpsyc.1997.01830130055011 Gardner, 2010, International consensus study of antipsychotic dosing, Am J Psychiatry, 167, 686, 10.1176/appi.ajp.2009.09060802 Peters, 2008, Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry, J Clin Epidemiol, 61, 991, 10.1016/j.jclinepi.2007.11.010 Duval, 2000, Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis, Biometrics, 56, 455, 10.1111/j.0006-341X.2000.00455.x Arato, 2002, A 1-year, double-blind, placebo-controlled trial of ziprasidone 40, 80 and 160 mg/day in chronic schizophrenia: the Ziprasidone Extended Use in Schizophrenia (ZEUS) study, Int Clin Psychopharmacol, 17, 207, 10.1097/00004850-200209000-00001 Beasley, 2003, A double-blind, randomized, placebo-controlled trial of olanzapine in the prevention of psychotic relapse, J Clin Psychopharmacol, 23, 582, 10.1097/01.jcp.0000095348.32154.ec Cooper, 2000, Zotepine in the prevention of recurrence: a randomised, double-blind, placebo-controlled study for chronic schizophrenia, Psychopharmacology, 150, 237, 10.1007/s002130000452 Gardos, 1984, Anticholinergic challenge and neuroleptic withdrawal: changes in dyskinesia and symptom measures, Arch Gen Psychiatry, 41, 1030, 10.1001/archpsyc.1983.01790220020003 Kramer, 2007, Paliperidone extended-release tablets for prevention of symptom recurrence in patients with schizophrenia: a randomized, double-blind, placebo-controlled study, J Clin Psychopharmacol, 27, 6, 10.1097/JCP.0b013e31802dda4a Leff, 1971, Trial of maintenance therapy in schizophrenia, BMJ, 3, 599, 10.1136/bmj.3.5775.599 Chen, 2010, Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial, BMJ, 341, c4024, 10.1136/bmj.c4024 Denijs, 1973, Pimozide (OrapR, R 6238) in residual schizophrenia: a clinical evaluation with long-term double-blind follow-up, Psychiatr Neurol Neurochir, 76, 47 Altman, 1998, Confidence intervals for the number needed to treat, BMJ, 317, 1309, 10.1136/bmj.317.7168.1309 Cheung, 1981, Schizophrenics fully remitted on neuroleptics for 3–5 years—to stop or continue drugs?, Br J Psychiatry, 138, 490, 10.1192/bjp.138.6.490 Sampath, 1992, Neuroleptic discontinuation in the very stable schizophrenic patient—relapse rates and serum neuroleptic levels, Hum Psychopharmacol, 7, 255, 10.1002/hup.470070405 Crow, 1986, A randomised controlled trial of prophylactic neuroleptic treatment, Br J Psychiatry, 148, 120, 10.1192/bjp.148.2.120 Boonstra, 2011, Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial, Int J Psychiatry Clin Pract, 15, 128, 10.3109/13651501.2010.534801 Caffey, 1964, Discontinuation or reduction of chemotherapy in chronic schizophrenics, J Chronic Dis, 17, 347, 10.1016/0021-9681(64)90075-X Hough, 2010, Paliperidone palmitate maintenance treatment in delaying the time-to-relapse in patients with schizophrenia: a randomized, double-blind, placebo-controlled study, Schizophr Res, 116, 107, 10.1016/j.schres.2009.10.026 Kane, 2011, A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment, J Clin Psychiatry, 72, 349, 10.4088/JCP.10m06306 Levine, 1980, Discontinuation of oral and depot fluphenazine in schizophrenic patients after one year of continuous medication: a controlled study, Adv Biochem Psychopharmacol, 24, 483 Peuskens, 2007, Prevention of schizophrenia relapse with extended release quetiapine fumarate dosed once daily: a randomized, placebo-controlled trial in clinically stable patients, Psychiatry, 4, 34 Pigott, 2003, Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study, J Clin Psychiatry, 64, 1048, 10.4088/JCP.v64n0910 Nishikawa, 1982, Prophylactic effect of neuroleptics in symptom-free schizophrenia, Psychopharmacology, 77, 301, 10.1007/BF00432759 Pietzcker, 1993, Intermittent versus maintenance neuroleptic long-term treatment in schizophrenia—2-year results of a German multicenter study, J Psychiatr Res, 27, 321, 10.1016/0022-3956(93)90059-B Hogarty, 1974, Drug and sociotherapy in the aftercare of schizophrenic patients: II two-year relapse rates, Arch Gen Psychiatry, 31, 603, 10.1001/archpsyc.1974.01760170005001 Hogarty, 1973, Drug and sociotherapy in the aftercare of schizophrenic patients: one-year relapse rates, Arch Gen Psychiatry, 28, 54, 10.1001/archpsyc.1973.01750310038007 Greenberg, 1966, Differential effects of abrupt versus gradual withdrawal of chlorpromazine in hospitalized chronic schizophrenic patients, Am J Psychiatry, 123, 221, 10.1176/ajp.123.2.221 Schooler, 1982, Research diagnosis for tardive dyskinesia, Arch Gen Psychiatry, 39, 468 Gleeson, 2010, A systematic review of relapse measurement in randomized controlled trials of relapse prevention in first-episode psychosis, Schizophr Res, 119, 79, 10.1016/j.schres.2010.02.1073 Schulz, 2010, CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials, BMJ, 340, c332, 10.1136/bmj.c332 Leucht, 2009, Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis, Lancet, 373, 31, 10.1016/S0140-6736(08)61764-X Davis, 1994, Depot antipsychotic drugs: place in therapy, Drugs, 47, 741, 10.2165/00003495-199447050-00004 Leucht, 2011, Oral versus depot antipsychotic drugs for schizophrenia—a critical systematic review and meta-analysis of randomised long-term trials, Schizophr Res, 127, 83, 10.1016/j.schres.2010.11.020